公开(公告)号：WO2016123481A3

公开(公告)日：2017-01-05

申请号：PCT/US2016015645

申请日：2016-01-29

Applicant: RGA INT CORP ,  YU BENJAMIN ,  GHOURI AHMED ,  RAYNER GARY ,  SUGAVANAM RAGHU ,  PAPP ZOLTAN

Inventor： YU BENJAMIN ,  GHOURI AHMED ,  RAYNER GARY ,  SUGAVANAM RAGHU ,  PAPP ZOLTAN

IPC: C12Q1/68 ,  G06F19/22 ,  G06F19/28

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6874 ,  G06F19/18 ,  G06F19/28 ,  G16H50/20 ,  Y02A90/26 ,  C12Q2535/122 ,  C12Q2537/143 ,  C12Q2545/114

Abstract: A condition can be diagnosed based on a symptom experienced by a subject and based on a biological sample including nucleic acids. Based on the symptom, a first set of the nucleic acids can be preselected for analysis. A first plurality of the nucleic acids of the first set that are present in the first biological sample can be captured. For each of the captured nucleic acids of the first plurality, an amount of that captured nucleic acid that is present in the first biological sample can be quantified and sequenced and based on the sequence of that captured nucleic acid, an origin of that captured nucleic acid can be identified. An indication can be output of the quantified amount and the identified origin of at least one captured nucleic acid that is present in the first biological sample.

Abstract translation: 可以基于受试者经历的症状并且基于包括核酸的生物样品来诊断病症。 基于症状，可以预先选择第一组核酸进行分析。 可以捕获存在于第一生物样品中的第一组的第一组多个核酸。 对于第一多个捕获的核酸中的每一个，存在于第一生物样品中的所捕获的核酸的量可以进行定量和测序，并且基于捕获的核酸的序列，捕获的核酸的来源 可以识别。 可以输出存在于第一生物样品中的至少一种捕获的核酸的量化量和鉴定的来源。

公开(公告)号：WO2016123481A2

公开(公告)日：2016-08-04

申请号：PCT/US2016/015645

申请日：2016-01-29

Applicant: RGA INTERNATIONAL CORPORATION ,  YU, Benjamin ,  GHOURI, Ahmed ,  RAYNER, Gary ,  SUGAVANAM, Raghu ,  PAPP, Zoltan

Inventor： YU, Benjamin ,  GHOURI, Ahmed ,  RAYNER, Gary ,  SUGAVANAM, Raghu ,  PAPP, Zoltan

IPC: C12Q1/68

CPC classification number: G06F19/22 ,  C12Q1/68 ,  C12Q1/6874 ,  G06F19/00 ,  G06F19/18 ,  G06F19/28 ,  G16H50/20 ,  Y02A90/26 ,  C12Q2535/122 ,  C12Q2537/143 ,  C12Q2545/114

Abstract: A condition can be diagnosed based on a symptom experienced by a subject and based on a biological sample including nucleic acids. Based on the symptom, a first set of the nucleic acids can be preselected for analysis. A first plurality of the nucleic acids of the first set that are present in the first biological sample can be captured. For each of the captured nucleic acids of the first plurality, an amount of that captured nucleic acid that is present in the first biological sample can be quantified and sequenced and based on the sequence of that captured nucleic acid, an origin of that captured nucleic acid can be identified. An indication can be output of the quantified amount and the identified origin of at least one captured nucleic acid that is present in the first biological sample.

Abstract translation: 可以基于受试者经历的症状并基于包括核酸的生物样品来诊断病症。 基于症状，可以预先选择第一组核酸进行分析。 可以捕获存在于第一生物样品中的第一组的第一组多个核酸。 对于第一多个捕获的核酸中的每一个，存在于第一生物样品中的所捕获的核酸的量可以进行定量和测序，并且基于捕获的核酸的序列，捕获的核酸的来源 可以识别。 可以输出存在于第一生物样品中的至少一种捕获的核酸的量化量和鉴定的来源。