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    SUSTAINED-RELEASE TABLET FORMULATION
    2.
    发明申请
    SUSTAINED-RELEASE TABLET FORMULATION 审中-公开
    可持续发布片剂制剂

    公开(公告)号：WO2005094831A1

    公开(公告)日：2005-10-13

    申请号：PCT/SG2005/000102

    申请日：2005-03-29

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  DSO NATIONAL LABORATORIES ,  YANG, Yi, Yan ,  TAN, Cherng-Wen, Darren ,  MOOCHHALA, Shabbir ,  WANG, Li-Shan ,  TAN, Donna

    Inventor： YANG, Yi, Yan ,  TAN, Cherng-Wen, Darren ,  MOOCHHALA, Shabbir ,  WANG, Li-Shan ,  TAN, Donna

    IPC: A61K31/522

    CPC classification number: A61K9/2031 ,  A61K9/2054 ,  A61K31/522

    Abstract: The invention provides a sustained-release tablet that can release caffeine and other xanthine derived stimulants at a nearly constant rate. The tablet comprises a hydrophilic polymer of high molecular weight and in one embodiment, the tablet includes caffeine and poly(ethylene oxide) of molecular weight of about 4 x 10 6 to 8 x 10 6. Sustained delivery of caffeine and other xanthine-derived stimulants is possible with a low concentration of the polymer and moreover, a wide range of concentration of caffeine and other stimulants can be released at a nearly constant rate.

    Abstract translation: 本发明提供一种能以几乎恒定的速率释放咖啡因和其他黄嘌呤衍生的兴奋剂的缓释片剂。 片剂包含高分子量的亲水性聚合物，在一个实施方案中，片剂包括分子量为约4×10 6至8×10 6的咖啡因和聚（环氧乙烷）。 咖啡因和其他黄嘌呤衍生的兴奋剂的持续输送是可能的，聚合物的浓度低，此外，咖啡因和其他兴奋剂的浓度范围可以以几乎恒定的速率释放。

    A METHOD AND APPARATUS FOR ANALYZING INTERACTIONS OF MOLECULES
    4.
    发明申请
    A METHOD AND APPARATUS FOR ANALYZING INTERACTIONS OF MOLECULES 审中-公开
    一种分析分子相互作用的方法和装置

    公开(公告)号：WO2013012396A1

    公开(公告)日：2013-01-24

    申请号：PCT/SG2012000259

    申请日：2012-07-20

    Applicant: AGENCY SCIENCE TECH & RES ,  TAN CHERNG-WEN DARREN ,  WIJAYA I PUTU MAHENDRA ,  HUNZIKER WALTER ,  SINNER EVA-KATHRIN ,  NALLANI MADHAVAN

    Inventor： TAN CHERNG-WEN DARREN ,  WIJAYA I PUTU MAHENDRA ,  HUNZIKER WALTER ,  SINNER EVA-KATHRIN ,  NALLANI MADHAVAN

    IPC: G01N33/48 ,  B81B7/00 ,  C12Q1/00 ,  G01N33/50

    CPC classification number: G01N33/5432 ,  G01N33/54366

    Abstract: The invention relates to a method and apparatus (500) for analyzing interactions of molecules of interest. Carriers, some of which are embedded with the molecules of interest, are used. The apparatus (500) comprises a microfluidic device (502) which in turn comprises a microfluidic channel (502a) and detectors (502b), and an operations unit (506). First and second samples (respectively comprising the embedded carriers and the remaining carriers) are caused to flow separately through the microfluidic channel (502a). The detectors (502b) are configured to detect presence of the carriers at respective positions along the channel (502a) during the flows. Based on the detections, the operations unit (506) determines rates at which the embedded carriers and the remaining carriers travel through the channel (502a), and obtains, based on a difference in the rates, data indicative of the amount of interactions of the molecules of interest during the flow of the first sample.

    Abstract translation: 本发明涉及用于分析感兴趣分子的相互作用的方法和设备（500）。 使用载体，其中一些嵌入感兴趣的分子。 装置（500）包括微流体装置（502）和操作单元（506），该微流体装置又包括微流体通道（502a）和检测器（502b）。 使第一和第二样品（分别包含嵌入载体和其余载体）分别流过微流体通道（502a）。 检测器（502b）被配置为在流动期间检测沿着通道（502a）的各个位置处的载体的存在。 基于检测结果，操作单元（506）确定嵌入式运营商和其余运营商通过信道（502a）行进的速率，并且基于速率的差异获得指示 在第一样品流动期间感兴趣的分子。

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