-
公开(公告)号：WO2009114487A2
公开(公告)日：2009-09-17
申请号：PCT/US2009036583
申请日：2009-03-09
Applicant: SENESCO TECHNOLOGIES INC , DONDERO RICHARD S , THOMPSON JOHN E , TAYLOR CATHERINE A
Inventor： DONDERO RICHARD S , TAYLOR CATHERINE A
IPC: A61K48/00 , C07H21/02 , C12N15/113 , C12N15/63
CPC classification number: C12N15/113 , A61K48/0008 , C07K14/4702 , C12N15/85 , C12N15/88 , C12N2310/14 , C12N2320/31
Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
-
2.发明申请USE OF SIRNA TO ACHIEVE DOWN REGULATION OF AN ENDOGENOUS GENE IN COMBINATION WITH THE USE OF A SENSE CONSTRUCT TO ACHIEVE EXPRESSION OF A DESIRED POLYNUCLEOTIDE 审中-公开使用SIRNA实现内源性基因与使用感觉结构相结合以实现所需多核苷酸表达的调控
公开(公告)号：WO2009114487A3
公开(公告)日：2009-11-05
申请号：PCT/US2009036583
申请日：2009-03-09
Applicant: SENESCO TECHNOLOGIES INC , DONDERO RICHARD S , THOMPSON JOHN E , TAYLOR CATHERINE A
Inventor： DONDERO RICHARD S , TAYLOR CATHERINE A
IPC: A61K48/00 , C07H21/02 , C12N15/113 , C12N15/63
CPC classification number: C12N15/113 , A61K48/0008 , C07K14/4702 , C12N15/85 , C12N15/88 , C12N2310/14 , C12N2320/31
Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
Abstract translation: 本发明涉及针对内源基因的siRNA的组合使用以敲除或敲低宿主中的内源基因的表达，并将编码该基因的多核苷酸在递送载体/表达载体中的递送至宿主 在宿主中提供由多核苷酸编码的蛋白质的表达。
-
公开(公告)号：WO2009114487A9
公开(公告)日：2009-09-17
申请号：PCT/US2009/036583
申请日：2009-03-09
Applicant: SENESCO TECHNOLOGIES, INC. , DONDERO, Richard S. , THOMPSON, John E. , TAYLOR, Catherine A.
Inventor： DONDERO, Richard S. , TAYLOR, Catherine A.
Abstract: The present invention relates to the combinatorial use of an siRNA targeted against an endogenous gene to knock out or knock down expression of the endogenous gene in a host and a delivery of a polynucleotide encoding the gene in a delivery vehicle/expression vector to the host to provide expression in the host of the protein encoded by the polynucleotide.
-
-
Search Results
3
records
(took 0.008 seconds)
