公开(公告)号：WO2019021150A1

公开(公告)日：2019-01-31

申请号：PCT/IB2018/055456

申请日：2018-07-23

申请人： TETHIS S.P.A.

发明人： CARBONE, Roberta ,  FRANCHI, Gian Martino ,  DE MARNI, Marzia Luigia

IPC分类号： G01N1/28 ,  G01N1/31 ,  G01N33/543 ,  G01N33/574 ,  B82Y30/00 ,  C12M1/12 ,  G01N1/30 ,  C12Q1/6841 ,  C12Q1/6886

摘要： A method for immobilising live cells within biological samples for analytical and diagnostic purposes that comprises the steps of providing a biological sample containing a predetermined number of cells to analyse; providing a planar support particularly suitable for use in an analytical device, the planar support comprising a surface functionalised with a surface coating comprising a nanostructured material; depositing a laminar layer of said biological sample on said functionalised surface of said planar support in order to cause the cells contained in the biological sample to adhere to the functionalised surface of the planar support; and positioning a fixative on the laminar layer of the biological sample. All of the above-mentioned steps are carried out at a temperature below at least 25° C.

公开(公告)号：WO2018065908A1

公开(公告)日：2018-04-12

申请号：PCT/IB2017/056106

申请日：2017-10-04

申请人： TETHIS S.P.A.

发明人： BARBORINI, Emanuele ,  VINATI, Simone ,  BAUMANN, Marc

IPC分类号： H01J49/04

摘要： There are described a new type of sample holder for performing analyses of biological samples with mass spectrometry in MALDI mode, the process for its production and some protocols for the use of the sample holder in said technique. The sample holder, in its simplest embodiment (10), consists of a support (11) on a face (12) of which there is at least one porous deposit (13) consisting of nanoparticles of an oxide of a Group 4 metal.

摘要翻译： 描述了一种用MALDI模式进行质谱法分析生物样品的新型样品架，其生产过程以及在所述技术中使用样品架的一些方案。 在其最简单的实施例（10）中，样本保持器由在其面（12）上的支撑件（11）组成，其中存在至少一个由第4族金属的氧化物的纳米颗粒组成的多孔沉积物（13） / p>

公开(公告)号：WO2023007422A1

公开(公告)日：2023-02-02

申请号：PCT/IB2022/056991

申请日：2022-07-28

申请人： TETHIS S.P.A.

发明人： FRANCHI, Gian Martino ,  CARBONE, Roberta ,  SCARINCI, Daniele Timothy ,  LECCARDI, Matteo Bruno ,  STEPIEN, Grazyna Elzbieta ,  BERTINI, Claudia

IPC分类号： G01N1/28 ,  G01N1/31 ,  G01N35/00

摘要： The present invention relates to an apparatus for the automated processing of a body fluid sample, preferably for analysis of liquid biopsy, configured to obtain one or more informative components of the fluid sample separate and distinct from each other, wherein a first component comprises cellular elements which result to be immobilized on planar supports, wherein a second component comprises suspension sample cells, and wherein a third component comprises the sample liquid fraction and it is preferably contained in a test tube. The invention further relates to a method for preparation of said components implemented by said apparatus.

公开(公告)号：WO2015121343A1

公开(公告)日：2015-08-20

申请号：PCT/EP2015/052951

申请日：2015-02-12

申请人： TETHIS S.P.A.

发明人： BANDIERA, Dario ,  BARBORINI, Emanuele ,  FRANCHI, Gian Martino ,  GATELLI, Massimo

IPC分类号： B01L3/00 ,  B01L9/00

CPC分类号： B01L9/52 ,  B01L3/5027 ,  B01L9/527 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2300/0816 ,  B01L2300/0822 ,  B01L2300/0887 ,  B01L2300/123

摘要： A device (1) for preparing a substrate (S) for processing samples comprises at least a cover (3) having a contact surface (3a) configured to come into contact with a substrate (S) and sealing means (4) located on the contact surface (3a) for latching onto the substrate (S), the cover (3) has a peripheral rim (3b) and an aperture (5) for handling fluids; a frame (6) having an engagement surface (6a) to be coupled with the substrate (S) and at least a window (7) into the engagement surface (6a), said window (7) having an edge (7a) to engage the rim (3b) for holding said cover (3) in a predetermined position with respect to the frame (6).

摘要翻译： 用于制备用于处理样品的衬底（S）的装置（1）至少包括具有接触表面（3a）的盖（3），所述接触表面（3a）被配置为与衬底（S）接触，并且密封装置 接触表面（3a）用于锁定到基底（S）上，盖（3）具有周边边缘（3b）和用于处理流体的孔（5） 具有与所述基板（S）连接的接合表面（6a）和至少一个窗口（7）进入所述接合表面（6a）的框架（6），所述窗口（7）具有边缘（7a）以接合 用于将所述盖（3）保持在相对于框架（6）的预定位置的边缘（3b）。