公开(公告)号：WO2020146906A2

公开(公告)日：2020-07-16

申请号：PCT/US2020/013417

申请日：2020-01-13

申请人： THE METHODIST HOSPITAL

发明人： WANG, Rongfu ,  WANG, Yicheng ,  ZHU, Motao ,  ZHAO, Ruifang

摘要： Disclosed are self-assembling nanoparticle compositions that comprise a plurality of cationic cell penetrating peptides, each covalently linked to a hydrophobic therapeutic molecule (e.g., an antigenic peptide, mRNA, siRNA, DNA, or the like), and optionally, non- covalently bound to at least one TLR (Toll-like receptor) ligand. Also disclosed are methods for use of the nanoparticle compositions in the treatment, prophylaxis, and/or the amelioration of one or more symptoms of a mammalian disease, including, without limitation, cancer, infection, inflammation, and related diseases and abnormal conditions.

公开(公告)号：WO2022046800A2

公开(公告)日：2022-03-03

申请号：PCT/US2021/047388

申请日：2021-08-24

申请人： UNIVERSITY OF SOUTHERN CALIFORNIA ,  THE METHODIST HOSPITAL SYSTEM ,  WANG, Rongfu ,  WANG, Yicheng ,  ZHU, Motao

发明人： WANG, Rongfu ,  WANG, Yicheng ,  ZHU, Motao

IPC分类号： C07K19/00 ,  A61K47/42 ,  C07K14/00 ,  C07K14/435 ,  C07K14/705

摘要： Disclosed herein are recombinant proteins and/or polypeptides comprising a Beclin 2 polypeptide and/or a targeting moiety and methods relating to treating, preventing, reducing, and/or inhibiting a cancer, metastasis, and/or a neurodegenerative disease comprising administering said recombinant protein or polypeptides.