公开(公告)号：WO2008048205A3

公开(公告)日：2008-04-24

申请号：PCT/US2006/023886

申请日：2006-06-20

申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR Intellectual Property Division ,  HEALTH RESEARCH, INC. ,  PRASAD, Paras, N. ,  PUDAVAR, Haridas, E. ,  BABA, Koichi ,  ROY, Indrajit ,  OHULCHANSKYY, Tymish ,  PANDEY, Ravindra, K. ,  OSEROFF, Allan

发明人： PRASAD, Paras, N. ,  PUDAVAR, Haridas, E. ,  BABA, Koichi ,  ROY, Indrajit ,  OHULCHANSKYY, Tymish ,  PANDEY, Ravindra, K. ,  OSEROFF, Allan

IPC分类号： A01N43/38 ,  A61K31/40

摘要： This invention provides nanocrystals or polymer doped nanocrystals of hydrophobic drug molecules as stably dispersed in an aqueous system which are prepared without stabilizers like surfactants and the like. In one embodiment, the drug is a tetra-pyrrole compound. An example is the hydrophobic photosensitizing anticancer drug 2-devinyl-2-(l - hexyloxyethyl) pyropheophorbide (HPPH). Pharmaceutical compositions comprising nanocrystals or polymer doped nanocrystals of hydrophobic drugs can be used for therapeutic purposes. For example pyropheophorbides such as HPPH can be used for photodynamic therapy. Drug efficacy of these nanocrystals were found to be comparable with that of same drug formulated in conventional delivery vehicles under in vitro and in vivo conditions.

公开(公告)号：WO2011050177A1

公开(公告)日：2011-04-28

申请号：PCT/US2010/053574

申请日：2010-10-21

申请人： HEALTH RESEARCH, INC. ,  PANDEY, Ravindra, K. ,  GUPTA, Anurag ,  THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR INTELLECTUAL PROPERTY DIVISION ,  SAJJAD, Munawwar ,  REGENTS OF THE UNIVERSITY OF MICHIGAN OFFICE OF TECHNOLOGY TRANFER ,  KOPELMAN, Raoul

发明人： PANDEY, Ravindra, K. ,  GUPTA, Anurag ,  SAJJAD, Munawwar ,  KOPELMAN, Raoul

IPC分类号： A61B5/00

CPC分类号： A61K41/0071 ,  A61K47/60 ,  A61K47/64 ,  A61K49/0002 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0093 ,  A61K51/0451 ,  A61K51/1255 ,  B82Y15/00

摘要： A composition comprising PAA nanoparticles containing a post loaded tetrapyrollic photosensitizer and an imaging agent and methods for making and using same.

摘要翻译： 一种包含PAA纳米颗粒的组合物，其包含后载荷的四光镜光敏剂和成像剂及其制备和使用方法。

公开(公告)号：WO2009114613A2

公开(公告)日：2009-09-17

申请号：PCT/US2009/036802

申请日：2009-03-11

申请人： HEALTH RESEARCH INC. ,  THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR INTELLECTUAL PROPERTY DIVISION ,  GURU, Khurshid ,  KESAVADAS, Thenkurussi ,  SRIMATHVEERAVALLI, Govindarajan

发明人： GURU, Khurshid ,  KESAVADAS, Thenkurussi ,  SRIMATHVEERAVALLI, Govindarajan

IPC分类号： A61B19/00 ,  B25J18/00 ,  B25J17/00 ,  B25J9/00

CPC分类号： B25J9/1671 ,  A61B34/30 ,  A61B34/37 ,  A61B34/74 ,  A61B2017/00707 ,  A61B2034/305 ,  A61B2090/365 ,  G05B2219/40168 ,  G05B2219/45117

摘要： A system according to the invention may include a frame, a computer, a display, and two input devices. The frame may be adjustable, may be made from a lightweight material, and may fold for easier portability. The display and the computer may be in communication with each other and each may be attached to the frame. The display may be a binocular display, or may be a touchscreen display. Additional displays may be used. Two input devices may be used to simulate the master console of a surgical robot. The input devices may be articulated armature devices suitable for providing 3D input. The input devices may be attached to the frame in an "upside-down" configuration wherein a base of each input device is affixed to the frame such that a first joint of an arm is below the base. The input devices may be in communication with the computer and may provide positional signals to the computer. The positional signals may correspond to a position of an arm of each input device.

摘要翻译： 根据本发明的系统可以包括框架，计算机，显示器和两个输入设备。 框架可以是可调节的，可以由轻质材料制成，并且可以折叠以便于便于携带。 显示器和计算机可以彼此通信，并且每个可以附接到框架。 显示器可以是双目显示器，或者可以是触摸屏显示器。 可以使用附加的显示器。 可以使用两个输入装置来模拟外科手术机器人的主控制台。 输入设备可以是适于提供3D输入的铰接式电枢装置。 输入设备可以以“倒置”配置附接到框架，其中每个输入设备的基座固定到框架，使得臂的第一接头在基座下方。 输入设备可以与计算机通信，并且可以向计算机提供位置信号。 位置信号可以对应于每个输入装置的臂的位置。

公开(公告)号：WO2006014493A2

公开(公告)日：2006-02-09

申请号：PCT/US2005/023990

申请日：2005-07-07

申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR ,  SACHS, Frederick ,  SUCHYNA, Thomas ,  GOTTLIEB, Phillip

发明人： SACHS, Frederick ,  SUCHYNA, Thomas ,  GOTTLIEB, Phillip

IPC分类号： A61K38/54 ,  C07K14/47 ,  C12P21/06

CPC分类号： C07K14/43518 ,  A61K38/00 ,  Y10S530/858

摘要： The present invention discloses a peptide of SEQ ID NO: 1 and its variants that blocks stretch-activated ion channels. All amino acids in this peptide are D-amino acids. The peptide, designated as D-GsMTx4, is an enantiomer of a peptide GsMTX-4 present in the venom of the spider Grammostola spatulata. The present invention also discloses a method for inhibition of stretch activated ion channels in a cell. This peptide can be used for the treatment of cardiac arrhythmias and other pathologies that involve alteartions in mechanical stress.

摘要翻译： 本发明公开了SEQ ID NO：1的肽及其延伸活化离子通道的变体。 该肽中的所有氨基酸都是D-氨基酸。 称为D-GsMTx4的肽是存在于蜘蛛Grammostola spatulata的毒液中的肽GsMTX-4的对映异构体。 本发明还公开了抑制细胞中拉伸活化离子通道的方法。 该肽可用于治疗心律失常和其他涉及机械应激中的alteartions的病态。

公开(公告)号：WO2008157493A2

公开(公告)日：2008-12-24

申请号：PCT/US2008/067118

申请日：2008-06-16

申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR INTELLECTUAL PROPERTY DIVISION ,  PRASAD, Paras, N. ,  KACHYNSKI, Aliaksandr ,  KUZMIN, Andrey ,  NYK, Marcin ,  ROY, Indrajit

发明人： PRASAD, Paras, N. ,  KACHYNSKI, Aliaksandr ,  KUZMIN, Andrey ,  NYK, Marcin ,  ROY, Indrajit

IPC分类号： C12Q1/00

CPC分类号： G01N33/588 ,  B82Y15/00

摘要： The present invention provides a method for imaging a biological specimen using non-linear optical properties of certain materials. The method comprises the steps of providing an aqueous dispersion of ZnO nanocrystals; contacting a biological specimen with an aqueous dispersion comprising ZnO nanocrystals; exposing the biological specimen to input electromagnetic radiation having a wavelength of from 600 to 1500 nm; recording the nonlinear output electromagnetic radiation; and generating an image of the biological specimen based on the nonlinear output radiation.

摘要翻译： 本发明提供一种使用某些材料的非线性光学性质对生物样本进行成像的方法。 该方法包括以下步骤：提供ZnO纳米晶体的水性分散体; 使生物样品与包含ZnO纳米晶体的水性分散体接触; 暴露生物样本以输入波长为600至1500nm的电磁辐射; 记录非线性输出电磁辐射; 以及基于所述非线性输出辐射生成所述生物样本的图像。

公开(公告)号：WO2006026033A2

公开(公告)日：2006-03-09

申请号：PCT/US2005/027382

申请日：2005-08-02

申请人： THE RESEARCH FOUNDATION OF STATE UNIVERSITY OF NEW YORK STOR ,  DETTY, Michael, R. ,  DONNELLY, David, J. ,  WAGNER, Stephen, J.

发明人： DETTY, Michael, R. ,  DONNELLY, David, J. ,  WAGNER, Stephen, J.

IPC分类号： A61K31/382 ,  A61K31/422 ,  C07D419/02 ,  C07D413/02

CPC分类号： C09B11/24 ,  C07D311/82 ,  C07D335/12 ,  C07D345/00 ,  C07D413/10 ,  C07D421/10 ,  Y02P20/582

摘要： Provided are chalcogenoxanthylium compounds which can effectively be used as sensitizers in photodynamic therapy, virucides in photodynamic antimicrobial chemotherapy and reversal agents of Pgp function in cancer cells. Further provided is a general method for the preparation of chalcogenoxanthylium compounds.

摘要翻译： 提供了可以有效地用作光动力疗法中的敏化剂的硫属元素compounds化合物，光动力学抗微生物化学疗法中的杀病毒剂和癌细胞中Pgp功能的逆转剂。 进一步提供了用于制备硫属元素compounds化合物的一般方法。