公开(公告)号：WO2018175418A1

公开(公告)日：2018-09-27

申请号：PCT/US2018/023332

申请日：2018-03-20

申请人： THE UNIVERSITY OF MONTANA ,  STIERLE, Andrea ,  STIERLE, Donald ,  PRIESTLEY, Nigel

发明人： STIERLE, Andrea ,  STIERLE, Donald ,  PRIESTLEY, Nigel

IPC分类号： C07D313/00 ,  C07D255/02 ,  C07G11/00 ,  A61P31/04 ,  A61P31/10 ,  A61K31/365 ,  A61K31/395

摘要： 16-membered macrolide compounds inhibit growth of various microbial species and have utility in the treatment of systemic or topical microbial infections, including methicillin-resistant strains (Formula I).

公开(公告)号：WO2011140131A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/035052

申请日：2011-05-03

申请人： BATTELLE ENERGY ALLIANCE, LLC ,  MONTANA TECH OF THE UNIVERSITY OF MONTANA ,  QUALTECH SYSTEMS, INC.

发明人： CHRISTOPHERSEN, Jon, P. ,  MORRISON, John, L. ,  MORRISON, William, H. ,  MOTLOCH, Chester, G. ,  ROSE, David, M.

IPC分类号： G01R27/02

CPC分类号： G01R31/3662

摘要： Estimating impedance of energy storage devices includes generating input signals at various frequencies with a frequency step factor therebetween. An excitation time record (ETR) is generated to include a summation of the input signals and a deviation matrix of coefficients is generated relative to the excitation time record to determine cross-talk between the input signals. An energy storage device is stimulated with the ETR and simultaneously a response time record (RTR) is captured that is indicative of a response of the energy storage device to the ETR. The deviation matrix is applied to the RTR to determine an in-phase component and a quadrature component of an impedance of the energy storage device at each of the different frequencies with the cross-talk between the input signals substantially removed. This approach enables rapid impedance spectra measurements that can be completed within one period of the lowest frequency or less.

摘要翻译： 估计能量存储装置的阻抗包括以各种频率产生输入信号，其间具有频率步长因子。 产生激励时间记录（ETR）以包括输入信号的和，并且相对于激励时间记录产生系数的偏差矩阵，以确定输入信号之间的串扰。 用ETR刺激能量存储装置，同时捕获指示能量存储装置对ETR的响应的响应时间记录（RTR）。 偏差矩阵被施加到RTR以确定在各个不同频率处的能量存储装置的阻抗的同相分量和正交分量，其中输入信号之间的串扰基本上被去除。 这种方法使得可以在最低频率或更低频率的一个周期内完成快速阻抗谱测量。

公开(公告)号：WO2010144857A3

公开(公告)日：2011-03-24

申请号：PCT/US2010038401

申请日：2010-06-11

申请人： MONTANA TECH OF THE UNIVERSITY OF MONTANA ,  MORRISON JOHN L ,  MORRISON WILLIAM H ,  CHRISTOPHERSEN JON P ,  MOTLOCH CHESTER G

发明人： MORRISON JOHN L ,  MORRISON WILLIAM H ,  CHRISTOPHERSEN JON P ,  MOTLOCH CHESTER G

IPC分类号： G01R23/16 ,  G01R27/02

CPC分类号： G01R31/2837

摘要： Methods of rapidly measuring the impedance spectrum of an energy storage device in-situ over a limited number of logarithmically distributed frequencies are described. An energy storage device is excited with a known input signal, and the response is measured to ascertain the impedance spectrum. The excitation signal is a limited time duration sum-of-sines consisting of a select number of frequencies. In one embodiment, magnitude and phase of each of frequency of interest within the sum-of-sines is identified when the selected frequencies and sample rate are logarithmic integer steps greater than two. This technique requires a measurement with a duration of one period of the lowest frequency. In another embodiment, where the selected frequencies are distributed in octave steps, the impedance spectrum can be determined using a captured time record that is reduced to a half-period of the lowest frequency.

摘要翻译： 描述了在有限数量的对数分布频率上现场快速测量能量存储装置的阻抗谱的方法。 用已知的输入信号激发能量存储装置，测量响应以确定阻抗谱。 激励信号是由选择频率组成的有限时间持续时间的和。 在一个实施例中，当所选择的频率和采样率是大于2的对数整数步长时，识别在正弦和之内的每个频率的幅度和相位。 该技术需要以最低频率的一个周期的持续时间进行测量。 在另一个实施例中，其中所选择的频率以八度步长分布，可以使用减少到最低频率的半周期的捕获时间记录来确定阻抗谱。

公开(公告)号：WO2004010775A2

公开(公告)日：2004-02-05

申请号：PCT/US2003/024079

申请日：2003-07-30

申请人： THE UNIVERSITY OF MONTANA ,  BROMENSHENK, Jerry ,  SECCOMB, Robert, A ,  RICE, Steven, D. ,  ETTER, Robert, T.

发明人： BROMENSHENK, Jerry ,  SECCOMB, Robert, A ,  RICE, Steven, D. ,  ETTER, Robert, T.

IPC分类号： A01K57/00

CPC分类号： A01K67/033 ,  A01K15/02 ,  A01K47/00 ,  A01K47/06 ,  A01K53/00 ,  A01K55/00 ,  F41H11/132

摘要： An integrated bee monitoring system for monitoring bee colonies in a hive is described. The system has a central microprocessor, at least two input transducers and at least two output signals. Input transducers include sensors which report the status of the colonies including colony weight, temperature, and relative humidity. A bee counter can also be included in the system to indicate colony activity. A bee counter is disclosed which uses an amplifying, multiplexes hysteresis and debounce circuitry to enable rapid and accurate polling of a single passageway. Information collected can be retrieved by read-out or liquid crystal display. Alternatively, information can be retrieved by telephone line or wireless communications. The bee monitoring system also can remotely control peripheral devices such as feeders or chemical samplers.

摘要翻译： 描述了一种用于监测蜂巢中蜂群的综合蜜蜂监测系统。 该系统具有中央微处理器，至少两个输入换能器和至少两个输出信号。 输入传感器包括报告菌落状态的传感器，包括菌落重量，温度和相对湿度。 蜂蜜计数器也可以包括在系统中以指示菌落活动。 公开了一种蜂计数器，其使用放大，多路复用滞后和去抖动电路以使得能够快速且准确地轮询单个通道。 收集的信息可以通过读出或液晶显示来检索。 或者，可以通过电话线或无线通信来检索信息。 蜜蜂监测系统还可以远程控制外部设备，如进料器或化学取样器。

公开(公告)号：WO2021076906A1

公开(公告)日：2021-04-22

申请号：PCT/US2020/056009

申请日：2020-10-16

申请人： CHILDREN'S MEDICAL CENTER CORPORATION ,  THE UNIVERSITY OF MONTANA ,  REGENTS OF THE UNIVERSITY OF MINNESOTA

发明人： DOWLING, David J. ,  LEVY, Ofer ,  SONI, Dheeraj ,  LEVY, Sharon ,  EVANS, Jay ,  PRAVETONI, Marco

IPC分类号： A61K31/4188 ,  A61K31/47 ,  A61K31/4738 ,  C07D215/00 ,  C07D215/38 ,  C07D235/00 ,  C07D471/04 ,  C07D473/00

摘要： Provided herein are TLR7/8 agonists to enhance immune responses or for use as adjuvants in fentanyl vaccines in opioid-using individuals.

公开(公告)号：WO2010099546A1

公开(公告)日：2010-09-02

申请号：PCT/US2010/025802

申请日：2010-03-01

申请人： THE UNIVERSITY OF MONTANA ,  POULSEN, David, J. ,  RAU, Thomas, Frederick

发明人： POULSEN, David, J. ,  RAU, Thomas, Frederick

IPC分类号： A01N33/02 ,  A61K31/135

CPC分类号： A61K31/137 ,  A61K9/0019 ,  A61K31/445 ,  A61K45/06 ,  A61K2300/00

摘要： A Method of reducing the occurrence of brain cell damage or death caused by transient cerebral hypoxia/ischemia condition or a traumatic brain injury (TBI) event. The method typically comprises identifying a subject with a transient cerebral hypoxic and/or ischemic condition, or a TBI, and within 24 hours of onset of the condition, administering to the subject a continuous intravenous infusion dose of methamphetamine in an amount sufficient to reduce the occurrence of brain cell damage or death caused by the condition. Preferably, in addition to the continuous intravenous infusion dose, a bolus dose of methamphetamine is administered to the subject as soon as possible after onset of the condition or occurrence of the TBI event.

摘要翻译： 一种减少由短暂性脑缺氧/缺血症或创伤性脑损伤（TBI）事件引起的脑细胞损伤或死亡的发生的方法。 该方法通常包括鉴定具有瞬时脑缺氧和/或缺血状况或TBI的受试者，并且在病症发作后24小时内，给予受试者持续的静脉内输注剂量的甲基苯丙胺，其量足以减少 发生脑细胞损伤或死亡所致的病情。 优选地，除了持续的静脉输注剂量之外，在病情发生或TBI事件发生之后，尽快向对象施用推注剂量的甲基苯丙胺。

公开(公告)号：WO2008024660A2

公开(公告)日：2008-02-28

申请号：PCT/US2007/076034

申请日：2007-08-15

申请人： THE UNIVERSITY OF MONTANA ,  POULSEN, David, J. ,  RAU, Thomas, Frederick

发明人： POULSEN, David, J. ,  RAU, Thomas, Frederick

IPC分类号： A61K31/445

CPC分类号： A61K31/445 ,  A61K31/135 ,  A61K31/137 ,  A61K31/4045 ,  A61K31/4458 ,  A61K45/06 ,  A61K2300/00

摘要： The present invention is directed to a method of reducing the occurrence of neuronal cell damage, including death, caused by transient cerebral hypoxia and/or ischemia. The method comprises the steps of: diagnosing a subject having a transient cerebral hypoxic and/or ischemic condition; and within 16 hours after onset of the condition, administering to the subject a neuroprotective amount of a pharmaceutical agent. The pharmaceutical agent is preferably selected from the group consisting of: a central nervous system stimulant (CNSS), monoamine neurotransmitter, monoamine oxidase inhibitor (MAOI), tricyclic antidepressant (TCA), or a combination thereof. Preferred agents include amphetamines, methamphetamine, methylphenidate, methylenedioxymethamphetamine, or a combination thereof.

摘要翻译： 本发明涉及减少由短暂脑缺氧和/或局部缺血引起的神经元细胞损伤（包括死亡）的发生的方法。 该方法包括以下步骤：诊断具有短暂脑缺氧和/或局部缺血症状的受试者; 并且在病症发作后的16小时内，向受试者施用神经保护量的药剂。 药剂优选选自由中枢神经系统兴奋剂（CNSS），单胺神经递质，单胺氧化酶抑制剂（MAOI），三环抗抑郁药（TCA）或其组合组成的组。 优选的药剂包括苯丙胺，甲基苯丙胺，哌甲酯，亚甲基二氧基甲基苯丙胺或其组合。

公开(公告)号：WO2008021054A3

公开(公告)日：2008-02-21

申请号：PCT/US2007/017493

申请日：2007-08-06

申请人： THE UNIVERSITY OF MONTANA ,  KIELY, Donald, E. ,  HASH, Kirk, R.

发明人： KIELY, Donald, E. ,  HASH, Kirk, R.

IPC分类号： C07C51/27 ,  C07C59/285

摘要： A controlled nitric acid process employing oxygen and nitric acid as co-oxidants is used to oxidize organic compounds subject to nitric acid oxidation, to their corresponding carboxylic acids. Oxidation of some carbohydrates by this process can produce one or more of their corresponding acid forms. The process is carried out at moderate temperatures, typically in the range of 20°C to 45 °C in a closed reactor, with oxygen gas being introduced into the reaction chamber as needed in order to sustain the reaction. Computer controlled reactors allow for careful and reproducible control of reaction parameters. Nitric acid can be recovered by a distillation / evaporation process, or by diffusion dialysis, the aqueous solution made basic with inorganic hydroxide, and the residual inorganic nitrate removed using a filtration (nanofiltration) device. The method eliminates issues of thermal control of the oxidation, release of nitrogen into the atmosphere, and post-reaction difficulties in the removal of nitric acid and inorganic nitrates.

公开(公告)号：WO2007127262A2

公开(公告)日：2007-11-08

申请号：PCT/US2007/010053

申请日：2007-04-26

申请人： THE UNIVERSITY OF MONTANA ,  GERDES, John, M. ,  BOLSTAD, David, B. ,  KUSCHE, Brian, R.

发明人： GERDES, John, M. ,  BOLSTAD, David, B. ,  KUSCHE, Brian, R.

IPC分类号： C07D401/04 ,  A61K31/4725 ,  G01N33/53

CPC分类号： C07D401/04

摘要： Racemic mixtures and individual enantiomers of fluorine-18 or carbon-11 radiolabeled 2'-alkyl-6-nitroquipazine ligands are serotonin transporter (SERT) tracers for positron emission tomography (PET) imaging. The non-radioactive ligand forms possess therapeutic antidepressant in vitro and in vivo pharmacological binding profiles in rodent brain and cells expressing human serotonin transporter (hSERT). Twelve 2'-alkyl-6-nitroquipazine ligands potently bind in sub-nanomolar concentrations to the pre-synaptic SERT binding site where established antidepressant drugs bind and inhibit the re-uptake of the neurotransmitter serotonin (5-HT). In vivo tracer studies in rats as well as monkey PET scan trial have demonstrated the fluorine-18 and carbon-11 positron radionuclide labeled tracers perform as quantitative tracers of specific binding the SERT protein in live brain.

摘要翻译： 氟-18或碳-11放射性标记的2'-烷基-6-硝基奎匹嗪配体的外消旋混合物和单独对映异构体是用于正​​电子发射断层摄影（PET）成像的血清素转运蛋白（SERT）示踪剂。 非放射性配体形式在啮齿动物脑和表达人血清素转运蛋白（hSERT）的细胞中的体外和体内药理学结合图谱中具有治疗性抗抑郁药。 12个2'-烷基-6-硝基奎匹嗪配体以亚纳摩尔浓度有力地结合到突触前SERT结合位点，其中建立的抗抑郁药物结合并抑制神经递质5-羟色胺（5-HT）的再摄取。 大鼠的体内示踪剂研究以及猴PET扫描试验已经证明，氟-18和碳-11正电子放射性核素标记的示踪剂作为活体脑中SERT蛋白特异性结合的定量示踪剂。

公开(公告)号：WO2006047251A2

公开(公告)日：2006-05-04

申请号：PCT/US2005/037823

申请日：2005-10-21

申请人： THE UNIVERSITY OF MONTANA ,  ESSLINGER, Christopher S. ,  BRIDGES, Richard J. ,  KAVANAUGH, Michael P.

发明人： ESSLINGER, Christopher S. ,  BRIDGES, Richard J. ,  KAVANAUGH, Michael P.

CPC分类号： C07C229/36

摘要： The present invention provides an L-aspartate derivative compound represented by the following structure (I) wherein Ar represents an aromatic group; L represents a linking moiety; R represents hydrogen, alkyl, aryl, or heteroaryl; and ~~~ indicates that the stereochemistry at the 3-position can be R or S. The compounds of the invention are useful for selectively inhibiting EAAT3 and for enhancing synaptic transmission. Additionally, the inventive compounds can be used to treat a patient suffering from Alzheimers disease or a neuropathy or a neurodegenerative disease in which L-glutamate transporter activity is involved in the onset of the disease.

摘要翻译： 本发明提供了由以下结构（I）表示的L-天冬氨酸衍生物化合物，其中Ar表示芳族基团; L代表连接部分; R代表氢，烷基，芳基或杂芳基; 并且~~~表示3-位的立体化学可以是R或S.本发明的化合物可用于选择性抑制EAAT3和增强突触传递。 另外，本发明的化合物可用于治疗患有阿尔茨海默氏病或​​神经病或神经退行性疾病的患者，其中L-谷氨酸转运体活性参与疾病的发作。