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13 条记录 (耗时 0.034 秒)

    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN
    2.
    发明申请
    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PATHOGENIC ANTIGEN 审中-公开
    用于组蛋白干扰素的核酸包封或编码，以及用于增加编码的病原性抗原表达的聚（A）序列或聚乙烯化信号

    公开(公告)号：WO2013120628A8

    公开(公告)日：2014-11-13

    申请号：PCT/EP2013000460

    申请日：2013-02-15

    申请人： CUREVAC GMBH ,  THESS ANDREAS ,  SCHLAKE THOMAS ,  PROBST JOCHEN

    发明人： THESS ANDREAS ,  SCHLAKE THOMAS ,  PROBST JOCHEN

    IPC分类号： C12N15/67 ,  A61K39/00

    CPC分类号： A61K39/145 ,  A61K39/00 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/64 ,  C12N7/00 ,  C12N15/63 ,  C12N15/67 ,  C12N2760/16134 ,  C12N2830/50

    摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of infectious diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising a pathogenic antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.

    摘要翻译： 本发明涉及包含或编码编码区的核酸序列，其编码至少一种包含病原性抗原或其片段，变体或衍生物的肽或蛋白质，至少一种组蛋白茎环和聚（A ）序列或聚腺苷酸化信号。 此外，本发明提供了用于增加所述编码的肽或蛋白质的表达的核酸的用途。 它还公开了其用于制备药物组合物，特别是疫苗的用途。 用于治疗传染病。 本发明还描述了使用包含或编码组蛋白茎环和聚（A）序列的核酸或增加包含病原性抗原或其片段，变体或衍生物的肽或蛋白质的表达的方法， 多聚腺苷酸化信号。

    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PROTEIN
    5.
    发明申请
    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED PROTEIN 审中-公开
    包含或编码用于增强编码蛋白质表达的聚（A）序列或聚烯丙基化信号的核酸

    公开(公告)号：WO2012019780A1

    公开(公告)日：2012-02-16

    申请号：PCT/EP2011/004077

    申请日：2011-08-12

    申请人： CUREVAC GMBH ,  THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    发明人： THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    IPC分类号： C12N15/67

    CPC分类号： A61K48/0066 ,  A61K39/0011 ,  A61K2039/53 ,  A61K2039/575 ,  C07K14/435 ,  C12N15/67

    摘要： The present application describes a coding nucleic acid sequence, particularly a messenger RNA (mRNA), comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and the use thereof for increasing the expression of an encoded protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine e.g. for the use in the treatment of tumours and cancer diseases, cardiovascular diseases, infectious diseases, autoimmune diseases or genetic diseases, or in gene therapy. The present invention further describes an in vitro transcription method, in vitro methods for increasing the expression of a protein using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal and an ex vivo and in vivo method.

    摘要翻译： 本申请描述了包含或编码组蛋白茎环和聚（A）序列或聚腺苷酸化信号的编码核酸序列，特别是信使RNA（mRNA），及其用途 用于增加编码蛋白质的表达。 它还公开了其用于制备药物组合物，特别是例如疫苗的用途。 用于治疗肿瘤和癌症疾病，心血管疾病，感染性疾病，自身免疫疾病或遗传疾病，或用于基因治疗。 本发明进一步描述了体外转录方法，使用包含或编码组蛋白茎环和聚（A）序列或聚腺苷酸化信号的核酸和离体的方法增加蛋白质表达的体外方法，和 体内方法。

    ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN OR PEPTIDE EXPRESSION
    6.
    发明申请
    ARTIFICIAL NUCLEIC ACID MOLECULES FOR IMPROVED PROTEIN OR PEPTIDE EXPRESSION 审中-公开
    用于改善蛋白质或肽表达的人造核酸分子

    公开(公告)号：WO2013143699A1

    公开(公告)日：2013-10-03

    申请号：PCT/EP2013/000937

    申请日：2013-03-27

    申请人： CUREVAC GMBH ,  THESS, Andreas

    发明人： THESS, Andreas

    IPC分类号： C12N15/67

    CPC分类号： C12N15/113 ,  A61K39/00 ,  A61K48/00 ,  A61K48/0008 ,  A61K2039/5156 ,  A61K2039/5256 ,  A61K2039/53 ,  C12N15/67 ,  C12N15/85 ,  C12N2310/531 ,  C12N2320/52 ,  C12N2840/105

    摘要： The invention relates to an artificial nucleic acid molecule comprising at least one 5'UTR element which is derived from a TOP gene, at least one open reading frame, and preferably at least one histone stem-loop. Optionally the artificial nucleic acid molecule may further comprise, e.g. a poly(A)sequence, a poyladenylation signal, and/or a 3'UTR. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination.

    摘要翻译： 本发明涉及包含至少一个5'UTR元件的人源核酸分子，其衍生自TOP基因，至少一个开放阅读框，优选至少一个组蛋白茎环。 任选地，人造核酸分子可以进一步包含，例如， poly（A）序列，poyladenylation信号和/或3'UTR。 本发明还涉及这种人工核酸分子在基因治疗和/或基因疫苗接种中的用途。

    ARTIFICIAL NUCLEIC ACID MOLECULES
    7.
    发明申请
    ARTIFICIAL NUCLEIC ACID MOLECULES 审中-公开
    人工核酸分子

    公开(公告)号：WO2013143698A1

    公开(公告)日：2013-10-03

    申请号：PCT/EP2013/000936

    申请日：2013-03-27

    申请人： CUREVAC GMBH ,  THESS, Andreas ,  KALLEN, Karl-Josef

    发明人： THESS, Andreas ,  KALLEN, Karl-Josef

    IPC分类号： C12N15/67 ,  C12N15/85

    CPC分类号： C12N15/85 ,  A61K48/00 ,  C12N15/67 ,  C12N15/88 ,  C12N2830/50

    摘要： The invention relates to an artificial nucleic acid molecule comprising at least one open reading frame and at least one 3'UTR element comprising a nucleic acid sequence which is derived from the 3'UTR of an albumin gene or from a variant of the 3'UTR of an albumin gene. The invention further relates to the use of such an artificial nucleic acid molecule in gene therapy and/or genetic vaccination. Furthermore, the invention relates to the use of a 3'UTR element comprising a nucleic acid sequence which is derived from the 3'UTR of an albumin gene or from a variant of the 3'UTR of an albumin gene for the stabilization and/or prolongation of protein expression from a nucleic acid sequence comprising such 3'UTR element.

    摘要翻译： 本发明涉及包含至少一个开放阅读框和至少一个3'UTR元件的人源核酸分子，其包含衍生自白蛋白基因的3'UTR或3'UTR的变体的核酸序列 的白蛋白基因。 本发明还涉及这种人工核酸分子在基因治疗和/或基因疫苗接种中的用途。 此外，本发明涉及包含衍生自白蛋白基因的3'UTR或白蛋白基因的3'UTR的变体的核酸序列的3'UTR元件用于稳定化和/或 从包含这种3'UTR元件的核酸序列延长蛋白质表达。

    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED TUMOUR ANTIGEN
    8.
    发明申请
    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED TUMOUR ANTIGEN 审中-公开
    包含或编码用于增强编码的肿瘤抗原表达的聚（A）序列或聚烯丙基化信号的核酸

    公开(公告)号：WO2013120627A1

    公开(公告)日：2013-08-22

    申请号：PCT/EP2013/000459

    申请日：2013-02-15

    申请人： CUREVAC GMBH ,  THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    发明人： THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    IPC分类号： C12N15/67 ,  A61K39/00

    CPC分类号： A61K39/0011 ,  A61K38/00 ,  A61K2039/53 ,  A61K2039/64 ,  C07K14/47 ,  C07K14/4703 ,  C07K14/4748 ,  C12N15/63 ,  C12N15/67 ,  C12N2830/50

    摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising a tumour antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of cancer or tumour diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising a tumour antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.

    摘要翻译： 本发明涉及包含或编码编码区的核酸序列，其编码至少一种包含肿瘤抗原或其片段，变体或衍生物的肽或蛋白质，至少一种组蛋白 茎环和聚（A）序列或聚腺苷酸化信号。 此外，本发明提供了所述核酸用于增加所述编码的肽或蛋白质的表达的用途。 它还公开了其用于制备药物组合物，特别是疫苗，例如， 用于治疗癌症或肿瘤疾病。 本发明进一步描述了一种使用包含或编码组蛋白茎环和多聚（A）序列的核酸或者包含组蛋白或其片段，变体或衍生物的肽或蛋白质的表达的方法，或者 聚腺苷酸化信号。

    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN
    9.
    发明申请
    NUCLEIC ACID COMPRISING OR CODING FOR A HISTONE STEM-LOOP AND A POLY(A) SEQUENCE OR A POLYADENYLATION SIGNAL FOR INCREASING THE EXPRESSION OF AN ENCODED ALLERGENIC ANTIGEN OR AN AUTOIMMUNE SELF-ANTIGEN 审中-公开
    包含或编码HISTON STEM环的核酸和用于增加编码的过敏原性抗原或自身免疫自体抗原表达的聚（A）序列或聚腺苷酸化信号

    公开(公告)号：WO2013120626A1

    公开(公告)日：2013-08-22

    申请号：PCT/EP2013/000458

    申请日：2013-02-15

    申请人： CUREVAC GMBH ,  THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    发明人： THESS, Andreas ,  SCHLAKE, Thomas ,  PROBST, Jochen

    IPC分类号： C12N15/68 ,  A61K39/00 ,  A61K39/35 ,  C12N15/117

    CPC分类号： A61K39/0008 ,  A61K39/35 ,  A61K48/00 ,  A61K48/005 ,  A61K2039/53 ,  A61K2039/55516 ,  A61K2039/64 ,  C12N15/63 ,  C12N15/67 ,  C12N15/85 ,  C12N2830/50 ,  Y02A50/401

    摘要： The present invention relates to a nucleic acid sequence, comprising or coding for a coding region, encoding at least one peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, at least one histone stem-loop and a poly(A) sequence or a polyadenylation signal. Furthermore the present invention provides the use of the nucleic acid for increasing the expression of said encoded peptide or protein. It also discloses its use for the preparation of a pharmaceutical composition, especially a vaccine, e.g. for use in the treatment of allergies or autoimmune diseases. The present invention further describes a method for increasing the expression of a peptide or protein comprising an allergenic antigen or an autoimmune self-antigen or a fragment, variant or derivative thereof, using the nucleic acid comprising or coding for a histone stem-loop and a poly(A) sequence or a polyadenylation signal.

    摘要翻译： 本发明涉及包含或编码编码区的核酸序列，所述核酸序列编码包含变应原性抗原或自身免疫自身抗原或其片段，变体或衍生物的至少一种肽或蛋白质 至少一个组蛋白茎环和聚（A）序列或聚腺苷酸化信号。 此外，本发明提供了所述核酸用于增加所述编码的肽或蛋白质的表达的用途。 它还公开了其用于制备药物组合物，特别是疫苗，例如， 用于治疗过敏症或自身免疫性疾病。 本发明进一步描述了使用包含或编码组蛋白茎环和核酸的核酸增加包含变应原性抗原或自身免疫自身抗原或其片段，变体或衍生物的肽或蛋白质的表达的方法， 聚（A）序列或聚腺苷酸化信号。