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公开(公告)号:WO2007070683A2
公开(公告)日:2007-06-21
申请号:PCT/US2006/047976
申请日:2006-12-14
申请人: CYTOKINETICS, INC. , MORGAN, Bradley, P. , MORGANS, David J., Jr. , MUCI, Alex , LU, Pu-Ping , KRAYNACK, Erica , TOCHIMOTO, Todd
发明人: MORGAN, Bradley, P. , MORGANS, David J., Jr. , MUCI, Alex , LU, Pu-Ping , KRAYNACK, Erica , TOCHIMOTO, Todd
IPC分类号: A61K31/5377 , A61K31/497 , A61K31/496 , A61K31/4965
CPC分类号: C07D213/75 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:WO2007078839A3
公开(公告)日:2007-07-12
申请号:PCT/US2006/047731
申请日:2006-12-14
申请人: CYTOKINETICS, INC. , MORGAN, Bradley P. , MORGANS, David J., Jr. , MUCI, Alex , LU, Pu-Ping , KRAYNACK, Erica , TOCHIMOTO, Todd
发明人: MORGAN, Bradley P. , MORGANS, David J., Jr. , MUCI, Alex , LU, Pu-Ping , KRAYNACK, Erica , TOCHIMOTO, Todd
IPC分类号: A61K38/00
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
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公开(公告)号:WO2004064730A3
公开(公告)日:2005-03-24
申请号:PCT/US2004001069
申请日:2004-01-14
申请人: CYTOKINETICS INC , MORGAN BRADLEY PAUL , ELIAS KATHLEEN A , KRAYNACK ERICA ANNE , LU PU-PING , MALIK FADY , MUCI ALEX , QIAN XIANGPING , SMITH WHITNEY WALTER , TOCHIMOTO TODD , TOMASI ADAM LEWIS , MORGANS DAVID J JR
发明人: MORGAN BRADLEY PAUL , ELIAS KATHLEEN A , KRAYNACK ERICA ANNE , LU PU-PING , MALIK FADY , MUCI ALEX , QIAN XIANGPING , SMITH WHITNEY WALTER , TOCHIMOTO TODD , TOMASI ADAM LEWIS , MORGANS DAVID J JR
IPC分类号: A61K20060101 , A61K31/17 , A61K31/34 , A61K31/35 , A61K31/424 , A61K31/44 , A61K31/4439 , A61K31/4545 , A61K31/5377 , C07C273/02 , C07C275/28 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/02 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/02 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
CPC分类号: A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2007070626A3
公开(公告)日:2008-04-17
申请号:PCT/US2006047672
申请日:2006-12-14
申请人: CYTOKINETICS INC , MORGAN BRADLEY P , LU PU-PING , MUCI ALEX , KRAYNACK ERICA , TOCHIMOTO TODD , MORGANS DAVID J JR
发明人: MORGAN BRADLEY P , LU PU-PING , MUCI ALEX , KRAYNACK ERICA , TOCHIMOTO TODD , MORGANS DAVID J JR
CPC分类号: C07D401/12 , A61K31/4439 , A61K31/496 , A61K31/498 , A61K31/5377 , A61K31/541 , A61K31/55 , C07D413/12 , C07D471/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物例如通过增强心肌肌球蛋白选择性地调节心肌细胞,并且可用于治疗收缩性心力衰竭,包括充血性心力衰竭。
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公开(公告)号:WO2007089336A2
公开(公告)日:2007-08-09
申请号:PCT/US2006/047668
申请日:2006-12-14
申请人: CYTOKINETICS, INC. , MORGAN, Bradley P. , MUCI, Alex , KRAYNACK, Erica , TOCHIMOTO, Todd , LU, Pu-ping , MORGANS, David J., Jr.
发明人: MORGAN, Bradley P. , MUCI, Alex , KRAYNACK, Erica , TOCHIMOTO, Todd , LU, Pu-ping , MORGANS, David J., Jr.
IPC分类号: A61K31/551 , A61K31/55 , A61K31/541 , A61K31/5377 , A61K31/496 , A61K31/497 , A61K31/506 , A61K31/501
CPC分类号: C07D401/12 , C07D213/75 , C07D239/42 , C07D261/14 , C07D403/12 , C07D413/12
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2007089336A3
公开(公告)日:2009-04-09
申请号:PCT/US2006047668
申请日:2006-12-14
申请人: CYTOKINETICS INC , MORGAN BRADLEY P , MUCI ALEX , KRAYNACK ERICA , TOCHIMOTO TODD , LU PU-PING , MORGANS DAVID J JR
发明人: MORGAN BRADLEY P , MUCI ALEX , KRAYNACK ERICA , TOCHIMOTO TODD , LU PU-PING , MORGANS DAVID J JR
IPC分类号: C07D471/02 , A61K31/4745
CPC分类号: C07D401/12 , C07D213/75 , C07D239/42 , C07D261/14 , C07D403/12 , C07D413/12
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2006009726A2
公开(公告)日:2006-01-26
申请号:PCT/US2005021100
申请日:2005-06-16
申请人: CYTOKINETICS INC , MORGAN BRADLEY P , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD , MORGANS DAVID
发明人: MORGAN BRADLEY P , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD , MORGANS DAVID
IPC分类号: A61K31/506 , A61K31/40 , A61K31/42 , A61K31/4439 , C07D403/02 , C07D413/02
CPC分类号: C07D213/75 , C07D211/56 , C07D239/42 , C07D261/14 , C07D263/48 , C07D271/113 , C07D295/26 , C07D401/10 , C07D401/12 , C07D417/00 , C07D417/10 , C07D417/12 , C07D487/04 , C07D491/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2004064730A2
公开(公告)日:2004-08-05
申请号:PCT/US2004/001069
申请日:2004-01-14
申请人: CYTOKINETICS, INC. , MORGAN, Bradley, Paul , ELIAS, Kathleen, A. , KRAYNACK, Erica, Anne , LU, Pu-Ping , MALIK, Fady , MUCI, Alex , QIAN, Xiangping , SMITH, Whitney, Walter , TOCHIMOTO, TODD , TOMASI, Adam, Lewis , MORGANS, David, J., Jr.
发明人: MORGAN, Bradley, Paul , ELIAS, Kathleen, A. , KRAYNACK, Erica, Anne , LU, Pu-Ping , MALIK, Fady , MUCI, Alex , QIAN, Xiangping , SMITH, Whitney, Walter , TOCHIMOTO, TODD , TOMASI, Adam, Lewis , MORGANS, David, J., Jr.
IPC分类号: A61K
CPC分类号: A61K31/44 , A61K31/17 , C07C275/30 , C07C275/34 , C07C275/36 , C07C275/40 , C07D207/12 , C07D211/42 , C07D213/65 , C07D213/70 , C07D213/75 , C07D217/04 , C07D401/12 , C07D405/12 , C07D413/12 , C07D417/12 , C07D498/04 , C07D513/04
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2007070683A3
公开(公告)日:2008-11-20
申请号:PCT/US2006047976
申请日:2006-12-14
申请人: CYTOKINETICS INC , MORGAN BRADLEY P , MORGANS DAVID J JR , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD
发明人: MORGAN BRADLEY P , MORGANS DAVID J JR , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD
IPC分类号: A61K31/496 , A61K31/4965 , A61K31/497
CPC分类号: C07D213/75 , A61K31/496 , A61K31/4965 , A61K31/497 , A61K31/5377
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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公开(公告)号:WO2007078839A2
公开(公告)日:2007-07-12
申请号:PCT/US2006047731
申请日:2006-12-14
申请人: CYTOKINETICS INC , MORGAN BRADLEY P , MORGANS DAVID J JR , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD
发明人: MORGAN BRADLEY P , MORGANS DAVID J JR , MUCI ALEX , LU PU-PING , KRAYNACK ERICA , TOCHIMOTO TODD
IPC分类号: A61K31/496 , C07D403/02 , C07D403/14
CPC分类号: C07D213/75 , C07D261/14 , C07D401/12 , C07D401/14 , C07D413/12
摘要: Certain substituted urea derivatives selectively modulate the cardiac sarcomere, for example by potentiating cardiac myosin, and are useful in the treatment of systolic heart failure including congestive heart failure.
摘要翻译: 某些取代的脲衍生物选择性地调节心肌肉瘤,例如通过增强心肌肌球蛋白,并且可用于治疗包括充血性心力衰竭的收缩性心力衰竭。
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