公开(公告)号：WO2010099316A1

公开(公告)日：2010-09-02

申请号：PCT/US2010/025409

申请日：2010-02-25

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H.

Inventor： TRIEU, Hai H.

IPC: A61B17/70

CPC classification number: A61B17/7026 ,  A61B17/7004 ,  A61B17/7031 ,  A61B2090/034

Abstract: A vertebral rod includes a first elongated section defining a first thickness. A second elongated section defines a second thickness. An intermediate section is disposed between the first section and the second section and defines a third thickness. The third thickness has a dimension being less than a dimension of at least one of the first thickness and the second thickness. The intermediate section has an inner surface that defines an open end. A resistance member has an exterior surface configured for engaging at least a portion of the inner surface.

Abstract translation: 椎骨杆包括限定第一厚度的第一细长部分。 第二细长部分限定第二厚度。 中间部分设置在第一部分和第二部分之间并且限定第三厚度。 第三厚度的尺寸小于第一厚度和第二厚度中的至少一个的尺寸。 中间部分具有限定开口端的内表面。 电阻构件具有被配置用于接合内表面的至少一部分的外表面。

公开(公告)号：WO2010051376A3

公开(公告)日：2010-07-15

申请号：PCT/US2009062582

申请日：2009-10-29

Applicant: WARSAW ORTHOPEDIC INC ,  TRIEU HAI H ,  HADDOCK SEAN M

Inventor： TRIEU HAI H ,  HADDOCK SEAN M

IPC: B01F5/04 ,  B01F7/16

CPC classification number: B01F15/0205 ,  B01F11/0082 ,  B01F13/002 ,  B01F13/0023 ,  B01F15/0201 ,  B01F15/0215 ,  B01F15/0224 ,  B01F15/0237 ,  B01F15/0279 ,  B01F2215/0027 ,  B01F2215/0029 ,  B01F2215/0034

Abstract: Mixing systems for storing and mixing multiple components of various medical compositions are provided. Generally, the instant mixing systems comprise a barrel, a plunger slidably disposed inside a barrel, and a pushing rod slidably disposed inside the plunger. The instant mixing system may further comprise multiple chambers for storing individual components or mixtures of components, with at least one chamber disposed in the barrel and at least one chamber disposed inside the plunger.

Abstract translation: 提供了用于存储和混合各种医疗组合物的多个组分的混合系统。 通常，瞬时混合系统包括筒体，可滑动地设置在筒体内的柱塞和可滑动地设置在柱塞内部的推杆。 即时混合系统可以进一步包括用于存储单独部件或组件混合物的多个室，其中至少一个室设置在筒体中，以及设置在柱塞内的至少一个室。

公开(公告)号：WO2008115725A1

公开(公告)日：2008-09-25

申请号：PCT/US2008/056476

申请日：2008-03-11

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H.

Inventor： TRIEU, Hai H.

IPC: A61B17/70 ,  A61B17/80

CPC classification number: A61B17/8028 ,  A61B17/7022 ,  A61B17/7059 ,  A61B17/8042 ,  A61B17/809 ,  A61B17/8605 ,  A61B2017/00004

Abstract: A stabilizing system (10) for stabilizing a patient's spinal column comprises a flexible implant (20) configured for attachment to a vertebral member, an anchor plate (30) for attaching the flexible implant to the vertebral member, and at least one fastener (50) to secure the anchor plate to the vertebral member. The anchoring plate has a bottom surface with one or more projections (36) configured to penetrate the top surface of the flexible implant when a clamping force is applied.

Abstract translation: 用于稳定患者脊柱的稳定系统（10）包括被配置为附接到椎骨构件的柔性植入物（20），用于将所述柔性植入物附接到椎骨构件的锚定板（30），以及至少一个紧固件 ）以将锚板固定到椎骨构件。 锚定板具有底表面，其中一个或多个凸起（36）构造成当施加夹紧力时穿透柔性植入物的顶表面。

公开(公告)号：WO2008079846A1

公开(公告)日：2008-07-03

申请号：PCT/US2007/088052

申请日：2007-12-19

Applicant: WARSAW ORTHOPEDIC, INC. ,  PROTOPSALTIS, Dimitri, K. ,  JUSTIS, Jeff, R. ,  TRIEU, Hai, H. ,  SHERMAN, Michael, C.

Inventor： PROTOPSALTIS, Dimitri, K. ,  JUSTIS, Jeff, R. ,  TRIEU, Hai, H. ,  SHERMAN, Michael, C.

IPC: A61B17/70 ,  A61B17/80 ,  A61B17/86 ,  A61F2/44

CPC classification number: A61B17/866 ,  A61B17/7013 ,  A61B17/7032 ,  A61B17/7049 ,  A61B17/80 ,  A61B17/8605 ,  A61B17/8625 ,  A61B17/8836 ,  A61F2/441 ,  A61F2/4425 ,  A61F2/4455 ,  A61F2/4465 ,  A61F2/447 ,  A61F2002/2835 ,  A61F2002/30062 ,  A61F2002/302 ,  A61F2002/30225 ,  A61F2002/30545 ,  A61F2002/30556 ,  A61F2002/30583 ,  A61F2002/30677 ,  A61F2002/30884 ,  A61F2002/3092 ,  A61F2002/444 ,  A61F2002/4495 ,  A61F2002/465 ,  A61F2210/0004 ,  A61F2210/0085 ,  A61F2230/0065 ,  A61F2230/0069 ,  A61F2250/0009 ,  A61F2250/001

Abstract: Orthopedic implants (100, 200, 300, 301, 320, 340, 400, 500, 600, 700, 720, 740, 760, 770, 800, 900, 1000, 1100, 1200, 1300, 1400, 1500, 1600, 1700, 1800) include a device that is non-rigid, i.e., flexible and/or malleable, in a first form for insertion into a desired in vivo site, and then transformable into a rigid, or hardened, form for providing a load-bearing function or providing other structural and/or mechanical function after implantation. The device includes a biocompatible sheath (110) and a curable material (120) sealed within the sheath (110). The curable material (120) is provided in a first form that provides flexibility to the device and is structured to rigidize in a second form after application of a quantity of an initiating energy to the material (120). Related methods and kits are also provided.

Abstract translation: 整形外科植入物（100,200,300,301,320,340,400,500,600,700,720,740,760,770,800,900,1000,1100,1200,1300， ，1400,1500,1600,1700,1800）包括第一种形式的非刚性，即柔性和/或可延展的装置，用于插入期望的体内部位，然后可变形为刚性的或硬化的 ，用于在植入后提供承重功能或提供其他结构和/或机械功能的形式。 该装置包括生物相容性护套（110）和密封在护套（110）内的可固化材料（120）。 所述可固化材料（120）以第一形式提供，所述第一形式为所述装置提供柔性并且构造成在向所述材料（120）施加一定量的引发能量之后以第二形式刚性化。 还提供了相关的方法和工具包。

公开(公告)号：WO2007127734A3

公开(公告)日：2008-04-24

申请号：PCT/US2007067305

申请日：2007-04-24

Applicant: WARSAW ORTHOPEDIC INC ,  TRIEU HAI H ,  CARLS THOMAS A ,  LIM ROY K ,  LANGE ERIC C ,  ANDERSON KENT M ,  BRUNEAU AURELIEN

Inventor： TRIEU HAI H ,  CARLS THOMAS A ,  LIM ROY K ,  LANGE ERIC C ,  ANDERSON KENT M ,  BRUNEAU AURELIEN

IPC: A61B17/70 ,  A61B17/88 ,  A61F2/44

CPC classification number: A61B17/7065 ,  A61F2/441 ,  A61F2002/30581

Abstract: An implant is disclosed and can include a body and a plurality of pellets disposed within the body. The implant can be moved between an unmolded, relaxed configuration wherein the body is not conformed to a bone and a molded, relaxed configuration wherein the body is at least partially conformed to the bone.

Abstract translation: 公开了一种植入物并且可以包括一个主体和设置在主体内的多个小球。 植入物可以在其中主体不符合骨的未模制的松弛构型和模制的松弛构型之间移动，其中主体至少部分地符合骨。

公开(公告)号：WO2007146616A3

公开(公告)日：2008-04-10

申请号：PCT/US2007070174

申请日：2007-06-01

Applicant: WARSAW ORTHOPEDIC INC ,  MCKAY WILLIAM F ,  GROSS JEFFREY M ,  TRIEU HAI H ,  ROY JOSEE ,  DRAPEAU SUSAN J ,  SCHENDEL MICHAEL J ,  WALSH ANDREW J L

Inventor： MCKAY WILLIAM F ,  GROSS JEFFREY M ,  TRIEU HAI H ,  ROY JOSEE ,  DRAPEAU SUSAN J ,  SCHENDEL MICHAEL J ,  WALSH ANDREW J L

IPC: A61B5/00 ,  A61B5/03 ,  A61B5/06 ,  A61B17/00 ,  A61B17/56 ,  C12Q1/00 ,  G01N33/94

CPC classification number: A61B5/14546 ,  A61B5/0031 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/032 ,  A61B5/14539 ,  A61B5/4514 ,  A61B5/4561 ,  A61B5/4824 ,  A61B5/4896 ,  A61B5/6848 ,  G01N33/54366 ,  G01N33/6896 ,  G01N2800/2842

Abstract: The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.

Abstract translation: 本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。 或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。 退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

公开(公告)号：WO2007146595A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/070019

申请日：2007-05-31

Applicant: WARSAW ORTHOPEDIC, INC ,  MCKAY, William F. ,  TRIEU, Hai H. ,  ROY, Josee ,  GROSS, Jeffrey M. ,  DRAPEAU, Susan J. ,  SCHENDEL, Michael J. ,  WALSH, Andrew J., L.

Inventor： MCKAY, William F. ,  TRIEU, Hai H. ,  ROY, Josee ,  GROSS, Jeffrey M. ,  DRAPEAU, Susan J. ,  SCHENDEL, Michael J. ,  WALSH, Andrew J., L.

IPC: A61K51/00 ,  A61K49/06 ,  A61K49/00

CPC classification number: A61K49/0004 ,  A61K49/00

Abstract: The invention provides methods and composition developed to be used with imaging techniques and useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening therapeutic compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degeneration include markers of neuronal, vascular, immune and matrix elements.

Abstract translation: 本发明提供了与成像技术一起使用并且可用于诊断和监测具有或不具有神经根病变的轴痛的疼痛发生器的方法和组合以及用于筛选潜在地可用于治疗具有或不具有神经根病变的轴向疼痛的治疗化合物的方法和组合物。 或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。 疼痛标记和变性标记包括神经元，血管，免疫和基质元件的标记。

公开(公告)号：WO2007127677A1

公开(公告)日：2007-11-08

申请号：PCT/US2007/067077

申请日：2007-04-20

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai H. ,  ANDERSON, Kent M. ,  LANGE, Eric C.

Inventor： TRIEU, Hai H. ,  ANDERSON, Kent M. ,  LANGE, Eric C.

IPC: A61B17/70

CPC classification number: A61B17/7065 ,  A61B2017/00557

Abstract: A multi-chamber expandable interspinous process brace (400) is disclosed and can include at least two chambers (402, 404). Each of the at least two chambers can receive an injectable biocompatible material. Further, the multi-chamber expandable interspinous process brace can be moved between a deflated configuration and an inflated configuration. In the inflated configuration, the multi-chamber expandable interspinous process brace can engage and support a superior spinous process and an inferior spinous process.

Abstract translation: 公开了一种多室可膨胀的棘突间过程支架（400），并且可以包括至少两个腔室（402,404）。 所述至少两个腔室中的每一个可以接收可注射的生物相容性材料。 此外，多室可扩张棘突间过程支架可以在放气构型和膨胀构型之间移动。 在充气结构中，多室可扩张棘突过程支架可以接合和支撑优良的棘突和下棘。

公开(公告)号：WO2007127588A1

公开(公告)日：2007-11-08

申请号：PCT/US2007/066051

申请日：2007-04-05

Applicant: WARSAW ORTHOPEDIC, INC ,  LANGE, Eric, C. ,  ANDERSON, Kent, M. ,  TRIEU, Hai, H.

Inventor： LANGE, Eric, C. ,  ANDERSON, Kent, M. ,  TRIEU, Hai, H.

IPC: A61B17/70

CPC classification number: A61B17/7065 ,  A61B17/7064 ,  A61B2017/00535 ,  A61B2017/00557

Abstract: A surgical implantation procedure and device according to which an expandable member is inserted between anatomical structures, and is expanded into engagement with the structures. The expansion is terminated when the member is in engagement with the structures.

Abstract translation: 一种手术植入程序和装置，根据该手术，可扩张构件插入在解剖结构之间，并且扩展成与结构接合。 当构件与结构接合时，膨胀终止。

公开(公告)号：WO2007117882A1

公开(公告)日：2007-10-18

申请号：PCT/US2007/064345

申请日：2007-03-20

Applicant: WARSAW ORTHOPEDIC, INC. ,  TRIEU, Hai, H.

Inventor： TRIEU, Hai, H.

IPC: A61B17/88 ,  A61B17/02

CPC classification number: A61B17/7065 ,  A61B2017/0256

Abstract: A system for implanting an interspinous process spacer (30) comprises a deformation instrument (42) adapted to engage a pair of opposing arms (34, 36, 38, 40) of the interspinous process spacer and operable to move the opposing arms relative to one another to deform the interspinous process spacer from an uncollapsed state to a collapsed state. The system further comprises a cannula (58) adapted to receive the collapsed interspinous process spacer from the deformation instrument and direct the interspinous process spacer to an area between a pair of spinous processes.

Abstract translation: 用于植入棘突间间隔物（30）的系统包括适于接合棘突间间隔物的一对相对臂（34,36,38,40）的变形器（42），并且可操作以相对于一个 另一个是将棘突间间隔物从未收缩状态变形到折叠状态。 系统还包括套管（58），其适于从变形仪器接收塌陷的棘突间间隔物，并将棘突间间隔物引导到一对棘突之间的区域。