公开(公告)号：WO2012129534A3

公开(公告)日：2012-09-27

申请号：PCT/US2012/030441

申请日：2012-03-23

Applicant: ANGIOTECH PHARMACEUTICALS, INC. ,  GROSS, Jeffrey, M. ,  DRUBETSKY, Lev ,  D'AGOSTINO, William, L. ,  HUNTER, William, L.

Inventor： GROSS, Jeffrey, M. ,  DRUBETSKY, Lev ,  D'AGOSTINO, William, L. ,  HUNTER, William, L.

IPC: A61B17/04 ,  A61B17/06 ,  A61L17/14 ,  D02J3/00

Abstract: A suture having a first end for penetrating tissue, an elongated suture body having a periphery; a plurality of retainers on the periphery, and a second end having a variable loop of variable circumference, wherein the variable loop includes a fixed loop slidably engaging the elongated body for slidingly varying the circumference of the variable loop, and wherein the first end may pass through the variable loop to secure tissue as an anchor, the anchor preventing movement of the suture in the direction of deployment of the first end.

公开(公告)号：WO2011140400A2

公开(公告)日：2011-11-10

申请号：PCT/US2011/035431

申请日：2011-05-05

Applicant: ANGIOTECH PHARMACEUTICALS, INC. ,  HUNTER, William, L. ,  GROSS, Jeffrey, M. ,  AVELAR, Rui

Inventor： HUNTER, William, L. ,  GROSS, Jeffrey, M. ,  AVELAR, Rui

IPC: A61B17/03 ,  A61B17/064 ,  D02J3/00

CPC classification number: A61B17/04 ,  A61B17/0401 ,  A61B17/06166 ,  A61B2017/00526 ,  A61B2017/0406 ,  A61B2017/0417 ,  A61B2017/06057 ,  A61B2017/0608 ,  A61B2017/06176

Abstract: A tissue retaining device includes a flexible suture thread having a surface microtexture and/or nanotexture. The surface microtexture and/or nanotexture filament is directional in that the resulting suture thread has a lower resistance to moving through tissue in the direction of intended deployment than in the reverse direction. A variety of alternative asymmetric textural elements and/or distributions of textural elements are disclosed. Methods for manufacturing the surface microtexture and/or nanotexture are also described.

Abstract translation: 组织保持装置包括具有表面微纹理和/或纳米纹理的柔性缝合线。 表面微纹理和/或纳米纹理细丝是方向性的，因为所产生的缝合线具有比在相反方向上沿着预期展开方向移动穿过组织的较低阻力。 公开了各种替代的非对称结构元件和/或结构元件的分布。 还描述了用于制造表面微纹理和/或纳米纹理的方法。

公开(公告)号：WO2007126989A3

公开(公告)日：2008-04-24

申请号：PCT/US2007007815

申请日：2007-03-29

Applicant: WARSAW ORTHOPEDIC INC ,  GROSS JEFFREY M ,  SERBOUSEK JON

Inventor： GROSS JEFFREY M ,  SERBOUSEK JON

IPC: A61M25/14

CPC classification number: A61B17/8811

Abstract: In one preferred aspect, a cannula is provided that has openings of different size to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different size into a patient. In yet another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.

Abstract translation: 在一个优选的方面，提供具有不同尺寸的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者的分布模式。 在另一方面，提供具有不同形状的开口的插管，以允许外科医生选择性地控制可流动材料通过插管并进入患者体内的分布模式。 在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同尺寸开口的插管到患者体内的分布模式。 在另一方面，提供了一种用于选择性地控制可流动材料通过具有不同形状的开口的套管到患者体内的分布模式的方法。

公开(公告)号：WO2007127666B1

公开(公告)日：2008-02-28

申请号：PCT/US2007066964

申请日：2007-04-19

Applicant: WARSAW ORTHOPEDIC INC ,  GROSS JEFFREY M ,  SERBOUSEK JON C

Inventor： GROSS JEFFREY M ,  SERBOUSEK JON C

IPC: A61B17/88

CPC classification number: A61B17/8811

Abstract: In one preferred aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.

Abstract translation: 在一个优选的方面，提供具有不同形状的开口的插管，以允许外科医生选择性地控制通过插管并进入患者的可流动材料的分布模式。 在另一方面，提供了一种方法，用于选择性地控制可流动材料通过具有不同形状的开口的套管到患者体内的分布模式。

公开(公告)号：WO2008005676A3

公开(公告)日：2008-02-21

申请号：PCT/US2007071292

申请日：2007-06-15

Applicant: WARSAW ORTHOPEDIC INC ,  TRIEU HAI H ,  HADDOCK SEAN M ,  SIMONTON T ANDREW ,  GROSS JEFFREY M ,  KINNANE KEITH M

Inventor： TRIEU HAI H ,  HADDOCK SEAN M ,  SIMONTON T ANDREW ,  GROSS JEFFREY M ,  KINNANE KEITH M

IPC: A61K9/00 ,  A61K31/00 ,  A61L17/08

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/728 ,  A61L27/24 ,  A61L2400/06 ,  A61L2430/38

Abstract: A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material.

Abstract translation: 公开了胶原材料并且可以包含多个颗粒。 每个颗粒可以包括具有一个或多个弓形部分和一个或多个直线部分的细长主体。 此外，每个颗粒可以包括从身体延伸的一种或多种纤维。 一个颗粒的一个或多个纤维可以接合一个或多个其他颗粒的一个或多个纤维以建立材料的基质。

公开(公告)号：WO2008005676A2

公开(公告)日：2008-01-10

申请号：PCT/US2007/071292

申请日：2007-06-15

Applicant: WARSAW ORTHOPEDIC, INC ,  TRIEU, Hai H. ,  HADDOCK, Sean M. ,  SIMONTON, T. Andrew ,  GROSS, Jeffrey M. ,  KINNANE, Keith M.

Inventor： TRIEU, Hai H. ,  HADDOCK, Sean M. ,  SIMONTON, T. Andrew ,  GROSS, Jeffrey M. ,  KINNANE, Keith M.

IPC: A61K9/00

CPC classification number: A61K9/0019 ,  A61K9/0024 ,  A61K31/00 ,  A61K31/728 ,  A61L27/24 ,  A61L2400/06 ,  A61L2430/38

Abstract: A collagen material is disclosed and can include a plurality of particles. Each particle can include an elongated, thin body having one or more arcuate portions and one or more straight portions. Further, each particle can include one or more fibers extending from the body. One or more fibers of one particle can engage the one or more fibers of one or more other particles to establish a matrix of material.

Abstract translation: 公开了胶原材料，并且可以包括多个颗粒。 每个颗粒可以包括具有一个或多个弓形部分和一个或多个直线部分的细长薄体。 此外，每个颗粒可以包括从身体延伸的一个或多个纤维。 一个颗粒的一个或多个纤维可以与一个或多个其它颗粒的一个或多个纤维接合以建立材料基质。

公开(公告)号：WO2007146616A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/070174

申请日：2007-06-01

Applicant: WARSAW ORTHOPEDIC, INC ,  MCKAY, William F. ,  GROSS, Jeffrey M. ,  TRIEU, Hai H. ,  ROY, Josee ,  DRAPEAU, Susan J. ,  SCHENDEL, Michael J. ,  WALSH, Andrew J.l.

Inventor： MCKAY, William F. ,  GROSS, Jeffrey M. ,  TRIEU, Hai H. ,  ROY, Josee ,  DRAPEAU, Susan J. ,  SCHENDEL, Michael J. ,  WALSH, Andrew J.l.

CPC classification number: A61B5/14546 ,  A61B5/0031 ,  A61B5/0071 ,  A61B5/0084 ,  A61B5/01 ,  A61B5/032 ,  A61B5/14539 ,  A61B5/4514 ,  A61B5/4561 ,  A61B5/4824 ,  A61B5/4896 ,  A61B5/6848 ,  G01N33/54366 ,  G01N33/6896 ,  G01N2800/2842

Abstract: The invention provides devices and related methods and composition useful for diagnosis and monitoring the pain generator(s) of axial pain with or without radiculopathy and methods for screening test compounds potentially useful for treating axial pain with or without radiculopathy. Alternatively, degenerated discs can be monitored and treated before occurrence of a pathological pain condition. Pain markers and markers of degenerating disc include markers of neuronal, vascular, immune and matrix elements.

Abstract translation: 本发明提供了用于诊断和监测具有或不具有神经根病变的轴向疼痛的疼痛发生器的装置和相关方法和组合，以及用于筛选潜在地可用于治疗或不发生神经根病变的轴向疼痛的测试化合物的方法。 或者，可以在发生病理性疼痛状况之前监测和治疗退化的椎间盘。 退行性椎间盘的疼痛标志物和标志物包括神经元，血管，免疫和基质元件的标记物。

公开(公告)号：WO2007127666A3

公开(公告)日：2007-11-08

申请号：PCT/US2007/066964

申请日：2007-04-19

Applicant: WARSAW ORTHOPEDIC, INC. ,  GROSS, Jeffrey M. ,  SERBOUSEK, Jon C.

Inventor： GROSS, Jeffrey M. ,  SERBOUSEK, Jon C.

IPC: A61B17/88

Abstract: In one preferred aspect, a cannula is provided that has openings of different shape to permit a surgeon to selectively control the distribution pattern of a flowable material through the cannula and into a patient. In another aspect, a method is provided for selectively controlling the distribution pattern of a flowable material through a cannula having openings of different shape into a patient.

公开(公告)号：WO2005030099A3

公开(公告)日：2005-07-28

申请号：PCT/US2004031089

申请日：2004-09-22

Applicant: SDGI HOLDINGS INC ,  GROSS JEFFREY M ,  SIMONTON THOMAS A

Inventor： GROSS JEFFREY M ,  SIMONTON THOMAS A

IPC: A61B17/70 ,  A61F2/00 ,  A61F2/02 ,  A61F2/28 ,  A61F2/30 ,  A61F2/44

CPC classification number: A61F2/28 ,  A61B17/7059 ,  A61F2/447 ,  A61F2002/2817 ,  A61F2002/2835 ,  A61F2002/30014 ,  A61F2002/30016 ,  A61F2002/30057 ,  A61F2002/30062 ,  A61F2002/30332 ,  A61F2002/30448 ,  A61F2002/30449 ,  A61F2002/30461 ,  A61F2002/30472 ,  A61F2002/30604 ,  A61F2002/30784 ,  A61F2210/0004 ,  A61F2220/0033 ,  A61F2220/0041 ,  A61F2220/005 ,  A61F2220/0075 ,  A61F2250/0018 ,  A61F2250/0019 ,  A61F2310/00017 ,  A61F2310/00161 ,  A61F2310/00179 ,  A61F2310/00329 ,  A61F2310/00365

Abstract: The present application provides a fusion implant (10) for use between adjacent bony structures and related methods. The implant includes a body (12) and at least one reinforcing member (24) positionable within the body.

Abstract translation: 本申请提供了一种在相邻骨结构和相关方法之间使用的融合植入物（10）。 植入物包括主体（12）和可定位在体内的至少一个加强构件（24）。

公开(公告)号：WO2005049103A2

公开(公告)日：2005-06-02

申请号：PCT/US2004038587

申请日：2004-11-17

Applicant: MEDTRONIC INC ,  MENSAH EUGENE A ,  CAPPS MARK J ,  COPPIN CHRIS M ,  GROSS JEFFREY M

Inventor： MENSAH EUGENE A ,  CAPPS MARK J ,  COPPIN CHRIS M ,  GROSS JEFFREY M

IPC: A61F2/24 ,  A61L27/16 ,  A61L27/18 ,  A61L27/50 ,  A61L27/54 ,  A61L27/00

CPC classification number: A61L27/50 ,  A61F2/2403 ,  A61F2/2412 ,  A61L27/16 ,  C08L35/04

Abstract: A heart valve sewing prosthesis including an intrinsically conductive polymer. The invention includes annuloplasty rings and bands, and sewing rings or cuffs for prosthetic heart valves. Some annuloplasty rings and sewing rings include fabric that is coated with an intrinsically conductive polymer. The coating can be formed over individual filaments or fibers, or on the fabric surface as a surface layer. One intrinsically conductive polymer is polypyrrole. The intrinsically conductive polymer can be doped to facilitate the intrinsic conductivity. Some devices have a polypyrrole surface layer doped with dialkyl-napthalene sulfonate. The intrinsically conductive polymer can be deposited on a fabric using in-situ polymerization of monomeric or oligomeric species, together with a dopant. Animal studies using implanted annuloplasty rings having an intrinsically conductive polymer coating have demonstrated a substantial reduction in pannus formation and inflammatory response.

Abstract translation: 包括本征导电聚合物的心脏瓣膜缝合假体。 本发明包括瓣环成形术环和带以及用于假体心脏瓣膜的缝合环或套囊。 一些瓣环成形术环和缝合环包括涂有本征导电聚合物的织物。 涂层可以形成在单独的长丝或纤维上，或者作为表面层形成在织物表面上。 一种本质上导电的聚合物是聚吡咯。 本征导电聚合物可以被掺杂以促进固有导电性。 一些装置具有掺杂有二烷基 - 萘磺酸盐的聚吡咯表面层。 本征导电聚合物可以使用单体或低聚物种与掺杂剂一起原位聚合而沉积在织物上。 使用具有固有导电聚合物涂层的植入的瓣环成形术环的动物研究已经证明pan骨形成和炎症反应显着减少。