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    METAL TREATMENT
    1.
    发明申请
    METAL TREATMENT 审中-公开
    金属处理

    公开(公告)号：WO2011154715A2

    公开(公告)日：2011-12-15

    申请号：PCT/GB2011/050984

    申请日：2011-05-25

    Applicant: ACCENTUS MEDICAL PLC ,  SHAWCROSS, James Timothy ,  TURNER, Andrew Derek ,  LEWIS, David Richard

    Inventor： SHAWCROSS, James Timothy ,  TURNER, Andrew Derek ,  LEWIS, David Richard

    IPC: C25D5/02

    CPC classification number: C25D5/02 ,  A61F2/30 ,  A61L27/04 ,  A61L27/54 ,  A61L2300/102 ,  A61L2400/18 ,  C25D11/022 ,  C25D11/024 ,  C25D11/26

    Abstract: Metal implants (10) are treated by anodising the surface (11, 12) in contact with an electrolyte, and then briefly subjecting the anodised surface to a reversed voltage. During a first anodising stage the surfaces are passivated, while during a subsequent anodising stage pits are formed in the passivating surface layer. Rough portions (15) of the surface, in particular portions produced by plasma spraying of metal powder, are sealed with a watertight cover (20) during at least part of the anodising process. After rinsing, biocidal metal ions are subsequently absorbed into the surface of the implant. This provides the implant with biocidal properties. The use of the cover (20) enables a more uniform geometric distribution of biocidal metal ions to be achieved.

    Abstract translation: 金属植入物（10）通过阳极氧化与电解质接触的表面（11,12）来处理，然后将阳极化表面短暂地经历反向电压。 在第一阳极氧化阶段期间，表面被钝化，而在随后的阳极氧化阶段期间，在钝化表面层中形成凹坑。 表面的粗糙部分（15），特别是通过等离子体喷涂金属粉末产生的部分在至少部分阳极氧化过程中用防水盖（20）密封。 在冲洗之后，杀生物金属离子随后被吸收到植入物的表面中。 这提供了具有杀生物性质的植入物。 使用盖（20）能够实现杀生物金属离子的更均匀的几何分布。

    MODIFIED VASOACTIVE INTESTINAL PEPTIDES
    2.
    发明申请
    MODIFIED VASOACTIVE INTESTINAL PEPTIDES 审中-公开
    改良的VASOACTIVE INTESTINAL PEPTIDES

    公开(公告)号：WO2011020091A1

    公开(公告)日：2011-02-17

    申请号：PCT/US2010/045605

    申请日：2010-08-16

    Applicant: PHASEBIO PHARMACEUTICALS, INC. ,  SADEGHI, Homayoun ,  TURNER, Andrew ,  DAGHER, Suzanne

    Inventor： SADEGHI, Homayoun ,  TURNER, Andrew ,  DAGHER, Suzanne

    IPC: A61K38/00 ,  A61K38/24

    CPC classification number: A61K38/2278 ,  A61K38/39 ,  A61K2300/00

    Abstract: The present invention provides modified Vasoactive Intestinal Peptides (VIPs), encoding polynucleotides and vectors, as well as pharmaceutical compositions comprising the same. The invention further provides methods of making and using the modified VIP agents. In accordance with the invention the VIP exhibits an extended circulatory half-life, receptor-binding or biological potency, and/or altered receptor binding profile with respect to unmodified VIP.

    Abstract translation: 本发明提供了修饰的血管活性肽肽（VIPs），编码多核苷酸和载体，以及包含其的药物组合物。 本发明还提供了制备和使用经修饰的VIP试剂的方法。 根据本发明，VIP相对于未修饰的VIP显示出延长的循环半衰期，受体结合或生物效力和/或改变的受体结合特征。

    METAL TREATMENT TO FORM A SURFACE LAYER
    3.
    发明申请
    METAL TREATMENT TO FORM A SURFACE LAYER 审中-公开
    金属处理形成表面层

    公开(公告)号：WO2010112910A1

    公开(公告)日：2010-10-07

    申请号：PCT/GB2010/050535

    申请日：2010-03-30

    Applicant: ACCENTUS MEDICAL PLC ,  TURNER, Andrew, Derek

    Inventor： TURNER, Andrew, Derek

    IPC: C25D11/26 ,  A61L27/04

    CPC classification number: C25D11/26 ,  A61F2/28 ,  A61L27/04 ,  A61L27/32 ,  A61L27/54 ,  A61L2300/104 ,  A61L2300/404 ,  A61L2300/606 ,  A61L2420/02

    Abstract: A metal object is treated to form an integral surface layer by: (a) immersing the metal object in an anodising electrolyte, and passivating the metal to form an anodised layer on the metal object; (b) continuing the application of a potential to modify the surface layer; (c) then treating the metal object with a chemical reducing agent so a hydrous metal oxide is formed; and (d) then contacting the metal object with a solution containing a biocidal material so as to incorporate biocidal material into the surface layer.

    Abstract translation: 通过以下方式处理金属物体以形成整体表面层：（a）将金属物体浸入阳极氧化电解质中，并钝化金属以在金属物体上形成阳极氧化层; （b）继续施加修改表面层的潜力; （c）然后用化学还原剂处理金属物体，形成含水金属氧化物; 和（d）然后使金属物体与含有杀生物材料的溶液接触，以将杀生物材料掺入表面层。

    METAL TREATMENT
    4.
    发明申请
    METAL TREATMENT 审中-公开
    金属处理

    公开(公告)号：WO2010112908A1

    公开(公告)日：2010-10-07

    申请号：PCT/GB2010/050531

    申请日：2010-03-29

    Applicant: ACCENTUS PLC ,  SHAWCROSS, James, Timothy ,  LEWIS, David, Richard ,  TURNER, Andrew, Derek

    Inventor： SHAWCROSS, James, Timothy ,  LEWIS, David, Richard ,  TURNER, Andrew, Derek

    IPC: C25D11/26 ,  A61L27/04

    CPC classification number: C23C28/00 ,  A61L31/022 ,  A61L31/088 ,  A61L31/16 ,  A61L2300/104 ,  A61L2300/404 ,  C25D11/24 ,  C25D11/26

    Abstract: Metal objects are treated by anodising (P, SE) the metal object in contact with an acidic solution, and then subjecting the anodised metal object to a reversed voltage (VR). The anodising is performed in two stages, firstly to passivate (P) with the formation of a surface layer, and secondly to form pits in this surface layer (SE). The second stage (SE) of anodising is performed at a lower voltage than the first stage (P). After the reversed voltage step (VR) the metal object is then contacted with a biocidal metal-containing solution. Biocidal metal is absorbed into the surface of the metal object, resulting in improved biocidal properties. The lower voltage of the second stage anodising (SE) results in reduced processing time.

    Abstract translation: 金属物体通过阳极氧化（P，SE）处理与酸性溶液接触的金属物体，然后使阳极化金属物体经受反向电压（VR）。 阳极氧化分两个阶段进行，先形成表面层钝化（P），其次在该表面层（SE）中形成凹坑。 阳极氧化的第二阶段（SE）在比第一阶段（P）低的电压下进行。 在反向电压步骤（VR）之后，金属物体然后与含杀生物金属的溶液接触。 杀生物金属被吸收到金属物体的表面，导致改善的杀生物性。 第二级阳极氧化（SE）的较低电压导致处理时间缩短。

    TRANSFERRIN FUSION PROTEIN LIBRARIES
    5.
    发明申请
    TRANSFERRIN FUSION PROTEIN LIBRARIES 审中-公开
    转铁蛋白融合蛋白质文库

    公开(公告)号：WO2008072075A2

    公开(公告)日：2008-06-19

    申请号：PCT/IB2007/003908

    申请日：2007-12-07

    Applicant: BIOREXIS PHARMACEUTICAL CORPORATION ,  TURNER, Andrew, John ,  WANG, Baiyang

    Inventor： TURNER, Andrew, John ,  WANG, Baiyang

    IPC: C07K14/76 ,  C07K14/79 ,  C12N15/62

    CPC classification number: C07K14/705 ,  C07K2319/035 ,  C07K2319/31 ,  C07K2319/70

    Abstract: Fusion proteins comprising a transferrin moiety and integrin binding domain and peptide libraries thereof are disclosed. The present invention includes a method of screening transferrin and integrin peptide libraries displayed in fusion proteins expressed by host cells. The fusion proteins of the present invention include transferrin fusion proteins capable of expression in yeast.

    Abstract translation: 公开了包含转铁蛋白部分和整联蛋白结合结构域的融合蛋白及其肽文库。 本发明包括筛选由宿主细胞表达的融合蛋白中显示的转铁蛋白和整联蛋白肽文库的方法。 本发明的融合蛋白包括能够在酵母中表达的转铁蛋白融合蛋白。

    METHANE RECOVERY
    9.
    发明申请
    METHANE RECOVERY 审中-公开
    甲烷回收

    公开(公告)号：WO2007080169A2

    公开(公告)日：2007-07-19

    申请号：PCT/EP2007/050198

    申请日：2007-01-09

    Applicant: GASREC LIMITED ,  TURNER, Andrew Derek ,  LILLEYSTONE, Richard John ,  CUTTS, George

    Inventor： TURNER, Andrew Derek ,  LILLEYSTONE, Richard John ,  CUTTS, George

    IPC: C10L3/08 ,  C10L3/10 ,  F28F13/12

    CPC classification number: F28D7/16 ,  B01D2258/05 ,  C10L3/08 ,  C10L3/10 ,  C10L3/102 ,  F28F9/0275 ,  F28F13/06 ,  Y02E50/346

    Abstract: A process is provided for recovering methane from landfill feed gas and other anaerobic digestors. The process comprising the following steps: firstly treating the feed gas to remove H 2 S; subsequently compressing the gas; and then treating the gas to remove further impurities. Additionally, there is provided a chiller for reducing the temperature of a gas flow. The chiller comprising: a shell arranged to be chilled, a plurality of bores through the shell and through which the gas flows, in use, and forming, together with the shell, a heat exchanger, a tangential inlet to each bore for creating a spiral flow of the gas through the bore, in use. Furthermore, a process is provided for purifying a gas feed using a reversible gas absorber unit comprising two hollow fibre gas/liquid contactors, each of which is arranged to provide a counter-current flow. The process comprising: setting up a partial pressure gradient in the first contactor using a reversible absorber capable of forming an adduct with the gas to be removed, introducing feed gas to the first contactor, forming an adduct of the gas to be absorbed, feeding the adduct to the second contactor, supplying a flushing counter-current flow to the second contactor to liberate the gas, and re-circulating the reversible absorber to the first contactor.

    Abstract translation: 提供了一种从垃圾填埋气和其他厌氧消化器回收甲烷的方法。 该方法包括以下步骤：首先处理进料气体以除去H 2 S; 随后压缩气体; 然后处理气体以除去进一步的杂质。 另外，提供了一种用于降低气流温度的冷却器。 冷却器包括：布置成被冷却的壳体，穿过壳体的多个孔，气体在使用中流动并与壳体一起形成热交换器，每个孔的切向入口用于产生螺旋 在使用中通过孔的气体流动。 此外，提供了使用包括两个中空纤维气体/液体接触器的可逆气体吸收器单元来净化气体进料的方法，每个中空纤维气体/液体接触器被布置成提供逆流。 该方法包括：使用能够与要除去的气体形成加合物的可逆吸收器在第一接触器中建立分压梯度，将进料气体引入第一接触器，形成待吸收气体的加合物， 加压到第二接触器，向第二接触器提供冲洗逆流以释放气体，并将可逆吸收体重新循环到第一接触器。

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