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公开(公告)号：WO2021108761A
公开(公告)日：2021-06-03
申请号：PCT/US2020/062493
申请日：2020-11-27
Applicant: UNIVERSITY OF MARYLAND, BALTIMORE [US]/[US] , U.S. DEPARTMENT OF VETERANS AFFAIRS [US]/[US] , THE UNITED STATES OF AMERICA, AS REPRESENTED BY THE SECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES [US]/[US]
Inventor： SAJADI, Mohammad , LUSSO, Paolo , LIU, Qingbo
Abstract: The present invention provides broadly neutralizing and potent antibodies against HIV, compositions comprising the same and methods of use thereof.
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2.发明申请
公开(公告)号：WO2018187320A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/025872
申请日：2018-04-03
Abstract: Disclosed herein is a footplate assembly for monitoring foot position in real time, as a wheelchair is driven. Optionally, the footplate assembly can use an array of force-sensing resistors and infrared distance sensors to detect the pressure and location of the foot within the immediate confines of the footplate. The footplate assembly can be provided as an overlay to an existing wheelchair footplate structure, or the footplate assembly can be integrated into or replace an existing wheelchair footplate structure.
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公开(公告)号：WO2015164629A1
公开(公告)日：2015-10-29
申请号：PCT/US2015/027334
申请日：2015-04-23
Applicant: THE REGENTS OF THE UNIVERSITY OF CALIFORNIA , U.S. DEPARTMENT OF VETERANS AFFAIRS OFFICE OF THE GENERAL COUNSEL
Inventor： ARDEHALI, Abbas
IPC: A61M25/00
CPC classification number: A61M25/0026 , A61M1/32 , A61M1/3659 , A61M2025/0031 , A61M2025/0037
Abstract: The present invention relates to a catheter for use with a lung assist device that minimizes or eliminates the recirculation of oxygenated blood. The catheter of the present invention can be used to drain blood from multiple points in the patient, namely the superior vena cava, right atrium, and the right ventricle, while returning blood to the patient's pulmonary artery. Further, the catheter of the present invention is less likely to be moved or dislodged than catheters currently available in the art, thus making the catheter particularly useful for portable lung assist devices. The present invention also relates to methods for inserting the catheter into the patient and using the catheter with a lung assist device. The present invention also relates to a portable lung assist device. In one embodiment, the portable lung assist device includes an integrated oxygenator, blood pump, and catheter. In one embodiment, the portable lung assist device of the present invention does not require an oxygen tank, but instead can provide oxygen to a subject's blood from ambient air.
Abstract translation: 本发明涉及一种用于肺辅助装置的导管，其最小化或消除了含氧血液的再循环。 本发明的导管可用于从患者的多个点（即上腔静脉，右心房和右心室）排出血液，同时将血液返回患者的肺动脉。 此外，本发明的导管比本领域目前可获得的导管更不容易移动或移动，因此导管对便携式肺辅助装置特别有用。 本发明还涉及将导管插入病人并使用具有肺辅助装置的导管的方法。 本发明还涉及便携式肺辅助装置。 在一个实施例中，便携式肺辅助装置包括集成的氧合器，血液泵和导管。 在一个实施例中，本发明的便携式肺辅助装置不需要氧气罐，而是可以向受试者的环境空气中的血液提供氧气。
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4.发明申请
公开(公告)号：WO2004098621A1
公开(公告)日：2004-11-18
申请号：PCT/US2003/019559
申请日：2003-07-17
Inventor： EATON, Mary, J., Ph.D.
IPC: A61K35/00
CPC classification number: A61K35/30 , C12N5/0619 , C12N2501/385
Abstract: Human cells isolated and/or cloned from human NT2 cells for expressing serotonin (5HT) and gamma-aminobutyric acid (GABA) are disclosed. These cells can be used as cellular minipumps to release serotonin and/or GABA to treat various neurological diseases, conditions, or disorders, particularly neurodegenerative disorders and the consequences of brain and spinal cord injuries (pain/spasticity).
Abstract translation: 公开了从人NT2细胞分离和/或克隆用于表达血清素（5HT）和γ-氨基丁酸（GABA）的人类细胞。 这些细胞可用作细胞微量血浆释放血清素和/或GABA以治疗各种神经疾病，病症或障碍，特别是神经变性疾病以及脑和脊髓损伤（疼痛/痉挛）的后果。
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公开(公告)号：WO2020176544A1
公开(公告)日：2020-09-03
申请号：PCT/US2020/019756
申请日：2020-02-25
Inventor： SALVEMINI, Daniela , FARR, Susan A.
IPC: A61K31/5377 , A61K31/519 , C07D487/04
Abstract: Disclosed herein are methods and compositions for the treatment of Alzheimer's disease by administering to a subject in need thereof a selective agonist for the human adenosine A3 receptor (A3AR) subtype. Also disclosed are methods and compositions for prophylactically treating Alzheimer's disease by administering to a subject in need thereof a selective agonist for the human adenosine A3 receptor (A3AR) subtype.
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Patent Agency Ranking6.发明申请
公开(公告)号：WO2020069208A1
公开(公告)日：2020-04-02
申请号：PCT/US2019/053285
申请日：2019-09-26
Inventor： BIKLE, Daniel D. , DESAI, Tejal A. , LE, Long V. , WANG, Yongmei
IPC: A61K31/519 , A61P19/02
Abstract: The present disclosure provides methods for treating or preventing osteoarthritis in a subject in need thereof. In certain aspects, the methods include administering an inhibitor of insulin growth factor-1 (IGF-1) signaling to a joint of the subject in an amount effective to treat or prevent osteoarthritis. In certain aspects, the osteoarthritis treated or prevented by the methods disclosed herein may be post-traumatic osteoarthritis.
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7.发明申请
公开(公告)号：WO2018187372A2
公开(公告)日：2018-10-11
申请号：PCT/US2018/025952
申请日：2018-04-03
Applicant: U.S. DEPARTMENT OF VETERANS AFFAIRS
Inventor： POTKAY, Joseph A.
IPC: F04D5/00
Abstract: Disclosed herein are rolled-membrane microfluidic diffusion devices and corresponding methods of manufacture. Also disclosed herein are three-dimensionally printed microfluidic devices and corresponding methods of manufacture. Optionally, the disclosed microfluidic devices can function as artificial lung devices.
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公开(公告)号：WO2018187340A1
公开(公告)日：2018-10-11
申请号：PCT/US2018/025902
申请日：2018-04-03
Applicant: U.S. DEPARTMENT OF VETERANS AFFAIRS
Inventor： FERGUSON, John , VOSS, Gregory, Owen , FAIRHURST, Stuart, Richard , HANSEN, Andrew
Abstract: Disclosed herein are devices, systems, and methods for measuring socket fit in lower limb prostheses and detecting motion of a residual limb relative to a prosthetic socket. Also disclosed herein are methods for developing a socket-fit detection system for sock management that can be applied to adjustable socket systems.
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公开(公告)号：WO2013081956A1
公开(公告)日：2013-06-06
申请号：PCT/US2012/066504
申请日：2012-11-26
Applicant: U.S. DEPARTMENT OF VETERANS AFFAIRS , ABEE, Catherine, P.
Inventor： ABEE, Catherine, P.
IPC: A61B5/1491
CPC classification number: A61B5/1491 , A61B5/14551 , A61B5/14552 , A61B5/6831
Abstract: Method and apparatus for providing reliable blood oxygen (Sa02) and heart rate measurements includes a chemical energy heating source in conjunction with a harness that is adapted to secure the chemical energy heating source and a pulse oximeter probe proximate to a region of the body which is to be warmed prior to measurement. Preferably, the chemical energy heating source is in the form a mixture including a metal powder, which releases heat at a predetermined rate via oxidation of the metal powder when exposed to the atmosphere. The apparatus may be designed to be reusable or disposable and can be used in a transmission or reflectance mode, or both.
Abstract translation: 用于提供可靠的血氧（Sa02）和心率测量的方法和装置包括结合线束的化学能量加热源，该线束适于将化学能量加热源和脉搏血氧计探针靠近身体的一个区域 在测量之前加热。 优选地，化学能量加热源为包含金属粉末的混合物的形式，金属粉末当暴露于大气中时通过金属粉末的氧化以预定的速率释放热量。 该设备可以被设计为可重复使用或一次性的，并且可以以透射或反射模式或两者使用。
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公开(公告)号：WO2020247012A1
公开(公告)日：2020-12-10
申请号：PCT/US2019/060836
申请日：2019-11-12
Inventor： BUTLER, Andrew , FARR, Susan , GIRARDET, Clemence
IPC: A61K38/17
Abstract: Disclosed are methods and compositions for treating cognitive decline in subjects in need. More specifically, disclosed are methods of administrating exogenous adropin to subjects suffering from, or at risk of, cognitive decline including the aged and those suffering from traumatic brain injury. Also disclosed are subjects who would benefit from such treatment and pharmaceutical acceptable compositions comprising adropin, adropin 34-76 , and derivatives or variations thereof.
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