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15 条记录 (耗时 0.012 秒)

    EXPRESSION, PREPARATION, USES, AND SEQUENCE OF RECOMBINANTLY-DERIVED SOLUBLE HLA-G
    3.
    发明申请
    EXPRESSION, PREPARATION, USES, AND SEQUENCE OF RECOMBINANTLY-DERIVED SOLUBLE HLA-G 审中-公开
    重组衍生的可溶性HLA-G的表达，制备，使用和序列

    公开(公告)号：WO0222784A2

    公开(公告)日：2002-03-21

    申请号：PCT/US0129228

    申请日：2001-09-17

    申请人： UNIV KANSAS MEDICAL CENTER ,  HUNT JOAN S ,  MORALES PEDRO J ,  PETROFF MARGARET G

    发明人： HUNT JOAN S ,  MORALES PEDRO J ,  PETROFF MARGARET G

    IPC分类号： C07K14/74 ,  C12N

    CPC分类号： C07K14/70539 ,  C07K2319/02

    摘要： Methods of producing and using recombinant soluble HLA-G are provided. This recombinant soluble HLA-G alters immune responses to tissues, organs, fetuses, and embryos which are genetically distinct from the organism receiving or possessing such antigenic material. Preferably forms of this protein include sequences having at least 70 % sequence homology with naturally occurring forms of HLA-G. Specifically, each recombinant form of HLA-G produced and used by the present methods must include a sequence having at least 70 % sequence homology to introm 4 expressed by the HLA-G gene and at least one sequence having at least 70 % sequence homology to one of the alpha domains expressed by the HLA-G gene. Preferable forms of the present invention include one isoform which includes the alpha 1 domain, the alpha 2 domain, the alpha 3 domain, and intron 4, and a second isoform which includes the alpha 1 domain, the alpha 3 domain and intron 4. Still more preferably, the sequences include a purification-assisting peptide sequence and a signal peptide.

    摘要翻译： 提供了生产和使用重组可溶性HLA-G的方法。 这种重组可溶性HLA-G改变与接受或拥有这种抗原物质的生物体基因不同的组织，器官，胎儿和胚胎的免疫应答。 优选地，该蛋白质的形式包括与天然存在的HLA-G形式具有至少70％序列同源性的序列。 具体地，本方法产生和使用的每种重组形式的HLA-G必须包括与HLA-G基因表达的内含子4具有至少70％的序列同源性的序列，以及与HLA-G基因表达的至少70％序列同源性的序列 HLA-G基因表达的α结构域之一。 本发明的优选形式包括包括α1结构域，α2结构域，α3结构域和内含子4的一种同种型，以及包括α1结构域，α3结构域和内含子的第二同种型。 更优选地，序列包括纯化辅助肽序列和信号肽。

    LIVE VIRUS VACCINES TO PROTECT PRIMATES FROM HIV-1 INFECTION AND DISEASE
    4.
    发明申请
    LIVE VIRUS VACCINES TO PROTECT PRIMATES FROM HIV-1 INFECTION AND DISEASE 审中-公开
    实时病毒疫苗保护母体免受HIV-1感染和疾病的侵害

    公开(公告)号：WO0018430A3

    公开(公告)日：2000-07-06

    申请号：PCT/US9922349

    申请日：1999-09-28

    申请人： UNIV KANSAS MEDICAL CENTER ,  NARAYAN OPENDRA

    发明人： NARAYAN OPENDRA

    IPC分类号： A61K39/21 ,  A61P31/12 ,  A61P31/18

    CPC分类号： A61K39/21 ,  A61K39/12 ,  A61K2039/53 ,  A61K2039/541 ,  A61K2039/542 ,  A61K2039/545 ,  C12N2740/15034 ,  C12N2740/16034

    摘要： The instant invention teaches pathogenic SHIV which cause AIDS in monkeys, the construction of virus for use in vaccines against pathogenic SHIV and HIV-1, and methods for prophylactic and therapeutic vaccination to prevent or inhibit HIV-1 infection and/or disease. The instant invention teaches the construction of modified live virus for use in vaccines against HIV-1, and methods for prophylactic and therapeutic vaccination to prevent or inhibit HIV-1 infection and/or disease. The instant invention teaches the use of viral DNA vaccines for the treatment and prevention of HIV infection and/or disease.

    摘要翻译： 本发明教导了在猴子中引起AIDS的病原性SHIV，构建了用于抗致病性SHIV和HIV-1的疫苗的病毒，以及用于预防和治疗性疫苗接种以预防或抑制HIV-1感染和/或疾病的方法。 本发明教导了构建用于针对HIV-1的疫苗的修饰的活病毒，以及用于预防和治疗性疫苗接种以预防或抑制HIV-1感染和/或疾病的方法。 本发明教导了使用病毒DNA疫苗来治疗和预防HIV感染和/或疾病。

    HORMONE REPLACEMENT THERAPY
    5.
    发明申请
    HORMONE REPLACEMENT THERAPY 审中-公开
    霍尔姆替代治疗

    公开(公告)号：WO2008147640A3

    公开(公告)日：2009-07-23

    申请号：PCT/US2008062644

    申请日：2008-05-05

    申请人： UNIV KANSAS MEDICAL CENTER ,  ZHU BAO TING

    发明人： ZHU BAO TING

    IPC分类号： A61K31/56

    CPC分类号： A61K31/56 ,  A61K2300/00

    摘要： A hormone replacement therapy formulation and method comprising selective estrogenic compounds which preferentially stimulate the estrogen receptor alpha over the estrogen receptor beta.

    摘要翻译： 一种激素替代疗法制剂和方法，其包括优选地在雌激素受体β上刺激雌激素受体α的选择性雌激素化合物。

    POLYPEPTIDES FOR BONE MINERALIZATION
    6.
    发明申请
    POLYPEPTIDES FOR BONE MINERALIZATION 审中-公开
    多用于骨矿化

    公开(公告)号：WO2008033488A3

    公开(公告)日：2008-12-24

    申请号：PCT/US2007019973

    申请日：2007-09-14

    申请人： UNIV KANSAS MEDICAL CENTER ,  ROWE PETER S N

    发明人： ROWE PETER S N

    IPC分类号： A61K38/00

    CPC分类号： C12N9/6489 ,  A61K38/00

    摘要： Polypeptides for improving bone mineralization and/or phosphate uptake are provided. The peptides include a PHEX zinc binding domain and two ASARM binding domains.

    摘要翻译： 提供了用于改善骨矿化和/或磷酸盐摄取的多肽。 肽包括PHEX锌结合结构域和两个ASARM结合结构域。

    SYSTEM AND METHOD FOR HIGH-RESOLUTION MAGNETIC RESONANCE IMAGING USING INDUCTIVELY-OVER-COUPLED COILS
    7.
    发明申请
    SYSTEM AND METHOD FOR HIGH-RESOLUTION MAGNETIC RESONANCE IMAGING USING INDUCTIVELY-OVER-COUPLED COILS 审中-公开
    使用电感耦合线圈进行高分辨率磁共振成像的系统和方法

    公开(公告)号：WO2007081805A3

    公开(公告)日：2008-06-05

    申请号：PCT/US2007000281

    申请日：2007-01-08

    申请人： UNIV KANSAS MEDICAL CENTER ,  BILGEN MEHMET

    发明人： BILGEN MEHMET

    IPC分类号： A61B5/05

    CPC分类号： G01R33/341 ,  A61B5/055 ,  G01R33/34084 ,  G01R33/3628 ,  G01R33/3692

    摘要： The present invention is directed to a tunable electromagnetic device for use in magnetic resonance imaging comprising a primary element (20) electrically coupled to an electromagnetic field generator (32), and a secondary element (10) positioned proximate the primary element, such that the two are inductively coupled. The secondary element is non- tunable, and preferably provided with a coating (16) to allow the element to be implanted within tissue. The primary element comprises tuning and matching circuitry (34, 36, 38) to vary the resonance frequency between the two elements to provide an inductive over- coupling between the two to provide a high resolution magnetic resonance image. Also disclosed is an associated method of using the system.

    摘要翻译： 本发明涉及一种用于磁共振成像的可调电磁装置，其包括电耦合到电磁场发生器（32）的主要元件（20）和邻近主要元件定位的次级元件（10），使得 两个电感耦合。 次要元件是不可调的，并且优选地设置有用于使元件植入组织内的涂层（16）。 主要元件包括调谐和匹配电路（34,36,38）以改变两个元件之间的谐振频率，以在两者之间提供感应过耦合以提供高分辨率磁共振图像。 还公开了使用该系统的相关方法。

    USE OF CRIPTO-1 AS A BIOMARKER FOR NEURODEGENERATIVE DISEASE AND METHOD OF INHIBITING PROGRESSION THEREOF
    9.
    发明申请
    USE OF CRIPTO-1 AS A BIOMARKER FOR NEURODEGENERATIVE DISEASE AND METHOD OF INHIBITING PROGRESSION THEREOF 审中-公开
    使用CRIPTO-1作为生物标记物进行神经损伤性疾病的方法及其抑制作用的方法

    公开(公告)号：WO2005033341A3

    公开(公告)日：2005-06-02

    申请号：PCT/US2004032649

    申请日：2004-10-01

    申请人： US GOV HEALTH & HUMAN SERV ,  UNIV KANSAS MEDICAL CENTER ,  SALOMON DAVID ,  BERMAN NANCY ,  STEPHENS EDWARD

    发明人： SALOMON DAVID ,  BERMAN NANCY ,  STEPHENS EDWARD

    IPC分类号： C12Q1/68

    CPC分类号： C07K16/18 ,  C12Q1/6883 ,  C12Q2600/158

    摘要： A method of detecting a neurodegenerative disease in a mammal, which method comprises assaying the copy number of a Cripto-1 gene or the expression level of a Cripto-1 gene product in the central nervous system of the mammal, wherein an amplification of the Cripto-1 gene or an overexpression of the Cripto-1 gene product is indicative of a neurodegenerative disease in the mammal; a method of inhibiting progression of a neurodegenerative disease in a mammal, which method comprises administering to the mammal an agent that inhibits Cripto-1 in an amount effective to inhibit Cripto-1 in the central nervous system of the mammal, whereupon the progression of the neurodegenerative disease is inhibited; and an isolated or purified oligonucleotide consisting essentially of the sequence of AAGCTATGGACTGCAGGAAGATGG (SEQ ID NO: 3) or AGAAGGCAGATGCCACTAGC (SEQ ID NO: 4).

    摘要翻译： 一种检测哺乳动物神经变性疾病的方法，该方法包括测定哺乳动物中枢神经系统中Cripto-1基因的拷贝数或Cripto-1基因产物的表达水平，其中Cripto -1基因或Cripto-1基因产物的过表达指示哺乳动物的神经变性疾病; 一种抑制哺乳动物神经变性疾病进展的方法，该方法包括向哺乳动物施用抑制Cripto-1的剂量，该抑制剂有效抑制哺乳动物中枢神经系统中的Cripto-1，因此， 神经变性疾病被抑制 和基本上由AAGCTATGGACTGCAGGAAGATGG（SEQ ID NO：3）或AGAAGGCAGATGCCACTAGC（SEQ ID NO：4）的序列组成的分离或纯化的寡核苷酸。

    COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN CANCER
    10.
    发明申请
    COMPOSITIONS AND METHODS FOR TREATMENT OF OVARIAN CANCER 审中-公开
    用于治疗OVARIAN癌症的组合物和方法

    公开(公告)号：WO2004064748A3

    公开(公告)日：2005-03-31

    申请号：PCT/US2004001382

    申请日：2004-01-20

    申请人： DARTMOUTH COLLEGE ,  UNIV KANSAS MEDICAL CENTER ,  WHITE HILLARY D ,  TERRANOVA KATHERINE FERN

    发明人： WHITE HILLARY D ,  TERRANOVA KATHERINE FERN

    IPC分类号： A61K20060101 ,  A61K31/519 ,  C07D487/02 ,  C12Q1/02

    CPC分类号： A61K31/519

    摘要： Compositions and methods for treatment of ovarian cancer are described. The compositions comprise antalarmin, a compound that increases cytotoxic T-cell lytic activity at tumor sites. Methods of treatment for ovarian cancer are based on the administration of antalarmin to increase cytotoxic T-cell lytic activity or anti-tumor activity, which leads to killing of tumor cells by cytotoxic T cells.

    摘要翻译： 描述了治疗卵巢癌的组合物和方法。 组合物包含抗肿瘤剂，其是在肿瘤部位增加细胞毒性T细胞裂解活性的化合物。 卵巢癌的治疗方法是基于施用安定乳剂以增加细胞毒性T细胞裂解活性或抗肿瘤活性，导致细胞毒性T细胞杀死肿瘤细胞。