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    MUTATED FORM OF NADPH OXIDASES
    4.
    发明申请
    MUTATED FORM OF NADPH OXIDASES 审中-公开
    NADPH氧化酶的突变形式

    公开(公告)号：WO2018014939A1

    公开(公告)日：2018-01-25

    申请号：PCT/EP2016/067140

    申请日：2016-07-19

    申请人： UNIVERSITA' DEGLI STUDI DI PAVIA

    发明人： MATTEVI, Andrea ,  NENCI, Simone ,  MAGNANI, Francesca

    IPC分类号： C12N9/06

    CPC分类号： C12N9/0036 ,  C12N9/0012

    摘要： The present invention relates to a mutation of the catalytic domain of a NADPH oxidase (NOX) and the use thereof to facilitate crystal structure determination, and to the corresponding mutated form of NOX and the use thereof to design and produce chemical scaffolds for the generation of NOX ligands effective in different diseases.

    摘要翻译： 本发明涉及NADPH氧化酶（NOX）的催化结构域的突变及其用于促进晶体结构测定的用途，以及涉及相应的突变形式的NOX及其用于设计 并生产用于产生对不同疾病有效的NOX配体的化学支架。

    TWO-PHOTON EXCITATED FLUORESCENCE MICROSCOPE
    5.
    发明申请
    TWO-PHOTON EXCITATED FLUORESCENCE MICROSCOPE 审中-公开
    双光子激发荧光显微镜

    公开(公告)号：WO2014154279A1

    公开(公告)日：2014-10-02

    申请号：PCT/EP2013/056681

    申请日：2013-03-28

    申请人： UNIVERSITA' DEGLI STUDI DI PAVIA

    发明人： TOMASELLI, Alessandra ,  TARTARA, Luca ,  HASANI, Elton

    IPC分类号： G02B21/00

    CPC分类号： G02B21/16 ,  G02B21/0032 ,  G02B21/025 ,  G02B27/0966 ,  G02B2207/114 ,  G02F1/3526

    摘要： It is disclosed a two-photon excited fluorescence microscope comprising a laser source suitable for emitting a light beam and an optical arrangement suitable for receiving the light beam from the laser source. The optical arrangement is configured for shaping the light beam so that, at the output of the microscope, the light beam is substantially collimated in a first transverse direction perpendicular to the propagation direction of the light beam at the microscope output and is focused in a second transverse direction perpendicular to the first transverse direction and to the propagation direction, thereby forming a line parallel to the first transverse direction.

    摘要翻译： 公开了一种双光子激发荧光显微镜，其包括适于发射光束的激光源和适于接收来自激光源的光束的光学装置。 光学布置被配置为使光束成形，使得在显微镜的输出处，光束在垂直于显微镜输出处的光束的传播方向的第一横向方向上基本准直，并且在第二 横向方向垂直于第一横向和传播方向，从而形成平行于第一横向的线。

    METHOD FOR ESTIMATING OR PREDICTING THE ANTI-TUMOR ACTIVITY OF A COMPOUND AND FOR ESTIMATING OR PREDICTING THE TUMOR GROWTH IN MAMMALS
    8.
    发明申请
    METHOD FOR ESTIMATING OR PREDICTING THE ANTI-TUMOR ACTIVITY OF A COMPOUND AND FOR ESTIMATING OR PREDICTING THE TUMOR GROWTH IN MAMMALS 审中-公开
    用于估计或预测化合物的抗肿瘤活性并估计或预测肿瘤肿瘤生长的方法

    公开(公告)号：WO2003079004A2

    公开(公告)日：2003-09-25

    申请号：PCT/EP2003/002689

    申请日：2003-03-14

    申请人： PHARMACIA ITALIA S.P.A. ,  UNIVERSITA' DEGLI STUDI DI PAVIA ,  CAMMIA, Cristiano ,  DE NICOLAO, Giuseppe ,  POGGESI, Italo ,  ROCCHETTI, Maurizio

    发明人： CAMMIA, Cristiano ,  DE NICOLAO, Giuseppe ,  POGGESI, Italo ,  ROCCHETTI, Maurizio

    IPC分类号： G01N33/00

    CPC分类号： G06F19/3456 ,  G06F19/00 ,  G06F19/321 ,  G16H50/50

    摘要： The present invention relates to a method for estimating or predicting the anti-tumor activity of a compound and for estimating or predicting the tumor growth in mammals; the estimation of the anti-tumor activity of a compound administered to mammals developing a tumor comprises a) measuring the tumor weight in time; b) measuring the concentration of the compound in time; c) calculating, on the basis of said measures, the following kinetic parameters of the tumor growth: a parameter (L 0 ), representative of the portion of the tumor cells present at the instant t 0 =0 that succeeds in taking root and in starting the tumor cells proliferation in the mammals; an index (λ O ) of the production rate of the tumor cells during an exponential phase of the tumor growth; -an index (λ 1 ) of the tumor cells mass produced in the time unit during a linear phase of the tumor growth; and the following pharmacodynamic parameters of the compound: an index (K 1 ) of the tumor cells death rate; an index (K 2 ) of the potency of the compound; and d) calculating, on the basis of said kinetic and pharmacodynamic parameters, tumor growth curves. The invention, applicable in the pharmaceutical field, allows to make the best use of all the information generated during the preclinical studies and results to be sufficiently simple also allowing to get good estimates or predictions regardless of the uncertainties on the mode of action. The invention further allows to employ a small number of parameters, therefore avoiding time consumption as well as a number of mechanistic observations.

    摘要翻译： 本发明涉及一种用于估计或预测化合物的抗肿瘤活性并估计或预测哺乳动物肿瘤生长的方法; 估计施用于发展肿瘤的哺乳动物的化合物的抗肿瘤活性包括：a）及时测量肿瘤重量; b）及时测定化合物的浓度; c）根据所述措施，计算肿瘤生长的以下动力学参数：代表在成功获得根的时刻t0 = 0处存在的肿瘤细胞部分的参数（L0），并开始 哺乳动物肿瘤细胞增殖; 肿瘤生长指数期肿瘤细胞产生率的指标（lambdO）; - 在肿瘤生长的线性期间以时间单位产生的肿瘤细胞量的指数（lambd1）; 和化合物的以下药效学参数：肿瘤细胞死亡率的指标（K1）; 该化合物的效力指数（K2）; 和d）根据所述动力学和药效学参数计算肿瘤生长曲线。 适用于制药领域的本发明允许最好地利用在临床前研究期间产生的所有信息，并且结果足够简单，还允许获得良好的估计或预测，而不考虑作用模式的不确定性。 本发明还允许采用少量参数，因此避免了时间消耗以及许多机械观察。