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公开(公告)号:WO2012156432A1
公开(公告)日:2012-11-22
申请号:PCT/EP2012/059083
申请日:2012-05-16
Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM , ZHANG, Hong , AALDERS, Maurice , VAN GOOL, Tom , UNIVERSITEIT VAN AMSTERDAM
Inventor: ZHANG, Hong , AALDERS, Maurice , VAN GOOL, Tom
IPC: G01N21/64 , G01N21/77 , G01N33/58 , G01N33/543 , A61B5/00
CPC classification number: G01N21/6428 , A61B5/0084 , B82Y15/00 , G01N21/648 , G01N21/7703 , G01N33/54346 , G01N33/588 , G01N2021/6432 , G01N2021/6484 , G01N2021/7786 , G01N2021/7793
Abstract: An activatable device (15) is provided which comprises a device (13) and an activatable imaging probe (1) attached to it. The probe comprises a chromophore (3) and an interaction moiety (5) attached to the chromophore. By interaction of a target (23) with the interaction moiety the optical properties of the probe are altered. An activatable imaging probe for attachment to such activatable device is also provided.
Abstract translation: 提供了一种可激活装置(15),其包括装置(13)和附接到其上的可激活的成像探头(1)。 探针包含发色团(3)和附着于发色团的相互作用部分(5)。 通过靶(23)与相互作用部分的相互作用,探针的光学性质被改变。 还提供了用于附接到这种可激活装置的可激活成像探针。
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公开(公告)号:WO2009126033A1
公开(公告)日:2009-10-15
申请号:PCT/NL2009/050182
申请日:2009-04-07
Applicant: ACADEMISCH MEDISCH CENTRUM BIJ DE UNIVERSITEIT VAN AMSTERDAM , Universiteit van Amsterdam , HOEBE, Ronald Antonius , MANDERS, Erik Martinus Marie
Inventor: HOEBE, Ronald Antonius , MANDERS, Erik Martinus Marie
CPC classification number: G02B21/0032
Abstract: The invention relates to a method for imaging an object, comprising the illumination of the object, and the detection of light coming from an area where the object is located and, based on the detected light, forming the image, with the illumination of the object taking place by distinguishing image elements in an imaging plane or space, and by separately illuminating the object parts corresponding with these image elements, while simultaneously registering the applied illumination dose of these object parts, and wherein the image is subsequently constructed by assembling the image elements corresponding with the illuminated object parts, subject to the light output and illumination doses pertaining to those image elements, wherein the illumination dose of each separate object part depends at least on a light output and/or illumination dose of another object part or several other object parts.
Abstract translation: 本发明涉及一种用于对物体进行成像的方法,包括对物体的照明,以及从物体所在区域的光的检测,并且基于检测到的光,形成图像,与物体的照明 通过在成像平面或空间中区分图像元素,并且通过分别照射与这些图像元素相对应的对象部分,同时记录这些对象部分的所施加的照射剂量,并且其中通过组合图像元素来构建图像 对应于照射对象部分,受到与这些图像元素相关的光输出和照射剂量的影响,其中每个分离的物体部分的照射剂量至少依赖于另一物体部分或其它几个物体的光输出和/或照明剂量 部分。
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公开(公告)号:WO2022263504A1
公开(公告)日:2022-12-22
申请号:PCT/EP2022/066294
申请日:2022-06-15
Applicant: DSM IP ASSETS B.V. , UNIVERSITEIT VAN AMSTERDAM
Inventor: HAMOEN, Leendert , WANG, Biwen
IPC: C07K14/32 , C12P21/02 , C12P7/02 , C12P13/02 , C12P17/04 , C12P17/06 , C12P17/12 , C12P23/00 , C12P25/00
Abstract: The present invention relates to a recombinant Bacillus host cell comprising a polynucleotide encoding a polypeptide of interest or encoding a polypeptide involved in the production of a compound of interest, wherein the host cell is deficient in the expression of a transcription repressor (CtsR) of class III heat shock genes. The invention further relates to a process for producing a polypeptide of interest, or a compound of interest, comprising cultivating the Bacillus host cell of the invention under conditions conducive for the production of the polypeptide or compound of interest.
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公开(公告)号:WO2022111935A1
公开(公告)日:2022-06-02
申请号:PCT/EP2021/079956
申请日:2021-10-28
Applicant: STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN , ASML NETHERLANDS B.V. , STICHTING VU , UNIVERSITEIT VAN AMSTERDAM
Inventor: KRAUS, Peter, Michael , ROSCAM ABBING, Sylvianne, Dorothea, Christina , CAMPI, Filippo , ZHANG, ZhuangYan , SMORENBURG, Petrus, Wilhelmus , LIN, Nan , WITTE, Stefan, Michiel , DEN BOEF, Arie, Jeffrey
Abstract: Disclosed is a metrology apparatus for measurement of a target formed on a substrate by a lithographic process and associated method. The metrology apparatus comprises a radiation source operable to provide first radiation; a configured solid high harmonic generation medium being configured to receive and be excited by said first radiation to generate high harmonic second radiation from an output surface of the configured solid high harmonic generation medium; and a detection arrangement operable to detect said second radiation, at least a portion of which having been scattered by said target. The configured solid high harmonic generation medium is configured to shape the beam of said second radiation and/or separate said first and second radiation.
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公开(公告)号:WO2022048899A1
公开(公告)日:2022-03-10
申请号:PCT/EP2021/072720
申请日:2021-08-16
Applicant: STICHTING VU , ASML NETHERLANDS B.V. , STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN , UNIVERSITEIT VAN AMSTERDAM
Inventor: LOETGERING, Lars , WITTE, Stefan, Michiel , PORTER, Christina, Lynn , SMORENBURG, Petrus, Wilhelmus
Abstract: Disclosed is a wavefront sensor for measuring a wavefront of a radiation. The wavefront sensor comprises a mask comprising a pattern located in path of the radiation to interact with the radiation. The radiation impinging on the mask forms a radiation detection pattern on a radiation detector subsequent to the mask, and the pattern of the mask is designed at least partly based on a requirement of the radiation detection pattern.
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公开(公告)号:WO2020016426A1
公开(公告)日:2020-01-23
申请号:PCT/EP2019/069548
申请日:2019-07-19
Applicant: UNIVERSITEIT VAN AMSTERDAM , VRIJE UNIVERSITEIT VAN BRUSSEL
Inventor: ADAMOPOULOU, Theodora , SCHOENMAKERS, Peter , DESMET, Gert , DERIDDER, Sander
Abstract: Device (1) for multi-dimensional liquid analysis, such as chromatography. The device comprises a first analysis channel (3) and one or more second analysis channels (5). The first analysis channel comprises a channel wall (21) with outlets (11) connecting the first analysis channel to one of the plurality of second analysis channels, and a valve (7) for opening or closing at least one of the one or more outlets (11)·
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公开(公告)号:WO2018224251A1
公开(公告)日:2018-12-13
申请号:PCT/EP2018/062557
申请日:2018-05-15
Applicant: STICHTING VU , STICHTING NEDERLANDSE WETENSCHAPPELIJK ONDERZOEK INSTITUTEN , UNIVERSITEIT VAN AMSTERDAM , ASML NETHERLANDS B.V.
Inventor: WITTE, Stefan, Michiel , ANTONCECCHI, Alessandro , ZHANG, Hao , EDWARD, Stephen , PLANKEN, Paulus, Clemens, Maria , GOORDEN, Sebastianus, Adrianus , HUISMAN, Simon, Reinald , SETIJA, Irwan, Dani , VLES, David, Ferdinand
IPC: G03F9/00
Abstract: A method for determining a characteristic of a feature in an object, the feature being disposed below a surface of the object is disclosed. The surface of the object is irradiated with a pulsed pump radiation beam so as to produce an acoustic wave in the object. The surface of the object is then irradiated with a measurement radiation beam. A portion of the measurement radiation beam scattered from the surface is received and a characteristic of the feature in the object is determined from at least a portion of the measurement radiation beam scattered from the surface within a measurement time period. A temporal intensity distribution of the pulsed pump radiation beam is selected such that in the measurement time period a signal to background ratio is greater than a signal to background ratio achieved using a single pulse of the pulsed pump radiation beam. The signal to background ratio is a ratio of: (a) signals generated at the surface by reflections of acoustic waves from the feature to (b) background signals generated at the surface by reflections of acoustic waves which have not reflected from the feature.
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公开(公告)号:WO2018194456A1
公开(公告)日:2018-10-25
申请号:PCT/NL2018/050250
申请日:2018-04-20
Applicant: UNIVERSITEIT VAN AMSTERDAM
Inventor: WEL, VAN DER, Eelco Jan , ULLRICH, Karin
Abstract: The invention provides an optical music recognition (OMR) assembly for converting sheet music, representing a music part as a first temporal representation, into a machine-processable representation of said piece of music that represents at least a pitch and duration of notes that are graphically represented in said sheet music and form said music part as a second temporal representation, said assembly comprising a data processor system and software which, when running on said data processor system: - retrieves a machine-processable representation of said sheet music; - generate a series of time slices of said sheet music, by applying a sliding window on said over said machine-processable representation of at least part of said sheet music; - defines a sequence-to-sequence system, said sequence-to-sequence system comprising: provide a convolutional neural network (CNN) for converting said time slices into a sequence of third representations of said sheet music, said CNN comprising an input layer and an output layer; provide a first, encoder recurrent neural network (RNN) as an encoder on said sequence of third representations, for providing a hidden representation of said sheet music, said first RNN having an input layer that is functionally coupled to said output layer of said CNN, and an output layer; * provide a second, decoder recurrent neural network (RNN) as a decoder to said hidden representation, for converting said hidden representation into said machine- processable representation, said second RNN having an input layer that is functionally coupled to said output layer of said first RNN, and an output for providing said machine-processable representation.
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公开(公告)号:WO2018151599A1
公开(公告)日:2018-08-23
申请号:PCT/NL2018/050107
申请日:2018-02-16
Applicant: UNIVERSITEIT VAN AMSTERDAM
Inventor: BREEDIJK, Ronald , MANDERS, Erik
Abstract: A method of forming a high-resolution image of a sample using a scanning microscope controlled by a processor is described wherein the method comprises the steps of receiving or generating control information for controlling a scanning microscope, the control information defining a plurality of different periodic patterns on the basis of one or more pattern parameters, preferably the one or more pattern parameters, including at least one of: a spatial frequency, a periodicity direction, an initial phase; using the control information to control the scanning microscope to expose the sample to multiple illumination patterns, each exposure to an illumination pattern causing one or more optical excitations in the sample, the light originating from said optical excitations forming an emission light signal; controlling an imaging system to capture multiple images, each image being associated with an emission light signal of one of the multiple exposures, and, using a structured light reconstruction algorithm for forming a high-resolution image on the basis of the one or more pattern parameters.
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公开(公告)号:WO2018106112A1
公开(公告)日:2018-06-14
申请号:PCT/NL2017/050820
申请日:2017-12-06
Inventor: RICHELLE, Gaston Julia Johannes , STREEFKERK, Dieuwertje Emma , VAN MAARSEVEEN, Jan Herman , TIMMERMAN, Peter
Abstract: The invention relates to methods for preparing a compound comprising a peptide attached to a molecular scaffold whereby multiple peptide loops are formed, to compounds that can be obtained with such methods and uses thereof.
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