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公开(公告)号：WO2023060194A1
公开(公告)日：2023-04-13
申请号：PCT/US2022/077696
申请日：2022-10-06
Inventor： BISWAS, Moanaro , RANA, Jyoti , BRUSKO, Todd Michael
IPC: A61K35/17 , A61K39/00 , A61P37/00 , C07K14/725 , C07K16/28
Abstract: Disclosed herein are compositions comprising engineered antigen-specific Tregs that suppress antibody formation against the soluble therapeutic protein factor VIII in an MHC-independent fashion. Complexing TCR-based signaling with single-chain variable fragment (scFv) recognition to generate TCR fusion construct (TRuC)-Tregs delivered controlled antigen-specific signaling via engagement of the entire TCR complex, thereby directing functional suppression of the FVIII-specific antibody response.
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公开(公告)号：WO2022232828A1
公开(公告)日：2022-11-03
申请号：PCT/US2022/071999
申请日：2022-04-29
Inventor： LEAR, William E.
Abstract: Various embodiments relate to a system and method of suppressing contrails emitted from an aircraft. One such system comprises a semi-closed cycle gas turbine engine of an aircraft that exhausts gases in use; a recuperator component that is positioned within an exhaust gas stream of the semi-closed cycle gas turbine engine to remove a portion of the exhaust gas stream in a form of heat energy; and one or more additional heat exchangers in a recirculation path that are configured to condense the heat energy of the portion of the exhaust gas to remove water vapor from the exhaust gas stream. Other systems and methods are also provided.
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公开(公告)号：WO2022213024A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/071287
申请日：2022-03-23
Inventor： JUTLA, Antarpreet S. , USMANI, Moiz , COLWELL, Rita
Abstract: The present disclosure provides systems and methods for predicting the occurrence of an outbreak of an infectious disease. One such method includes acquiring environmental risk factor data associated with a particular disease, wherein the environmental risk factor data corresponds to a particular geographic region; acquiring social risk factor data associated with the particular disease; applying a prediction algorithm to the environmental and social risk factor data to generate a disease risk model for generating at least a trigger prediction and a transmission prediction for a disease-causing pathogen at the particular geographic region; generating the trigger prediction by applying the disease risk model to a forecast of data for a first lead time for the particular geographic region; and/or generating the transmission prediction by applying the disease risk model to the transmission prediction for a second lead time for the particular geographic region. Other methods and systems are also provided.
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公开(公告)号：WO2022170316A1
公开(公告)日：2022-08-11
申请号：PCT/US2022/070466
申请日：2022-02-02
Inventor： SUBHASH, Ghatu , LEONARD, Richard Y., III , WHITTINGTON, Wilburn
Abstract: The present disclosure relates to compact waveguides. One example includes a primary bar, and an impedance-matched series of secondary bars that is impedance-matched with the primary bar at a connection point that joins at least one secondary bar of the impedance-matched series of secondary bars to the primary bar. The secondary bars are noncollinear and nonconcentric with the primary bar.
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公开(公告)号：WO2022165483A1
公开(公告)日：2022-08-04
申请号：PCT/US2022/070341
申请日：2022-01-25
Inventor： SRINIVASAN, Ravi Shankar , NAWARI, Nawari O.
Abstract: The present disclosure describes system and methods for determination of building code performance. One such method comprises performing design model validation, wherein design model validation comprises entering building permit application file information and checking the building permit application file information against relevant codes and regulations, using a taxonomy or neural natural language processing techniques or artificial Intelligence; performing exchange model code checking, wherein exchange model code checking comprises using a plurality of exchange models; performing code conformance checking, wherein the code conformance checking comprises receiving a request from the exchange models and passing the building permit application file information to code checking modules configured to check building code provisions and one or more regulations per local, state, national or international requirements; performing verification reporting based on input provided from the code checking modules; and performing results reporting based on findings of the verification reporting.
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Patent Agency Ranking
公开(公告)号：WO2021247652A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035376
申请日：2021-06-02
Inventor： VIDYASAGAR, Sadasivan , GROSCHE, Astrid , XU, Xiaodong , LIN, Shanshan , GATTO, Stephen , KENEFICK, Robert , CHEUVRONT, Samuel
IPC: A61K36/47 , A61K31/353 , A61K35/74
Abstract: Amino acid formulations useful for treating diarrhea in a subject in need thereof are described herein. Such amino acid formulations and methods comprising administering same to a subject are useful for treating diarrhea, particularly diarrhea caused by or associated with bacterial infections wherein secretagogue-stimulated anion secretion from the intestinal crypt contributes to at least one symptom of diarrhea in the subject. Use of these amino acid formulations for the treatment of diarrhea in general or diarrhea associated with secretagogue-stimulated anion secretion from the intestinal crypt are encompassed herein, as are their use in the preparation of a medicament for the treatment of diarrhea in general or diarrhea associated with secretagogue- stimulated anion secretion from the intestinal crypt.
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公开(公告)号：WO2020214399A2
公开(公告)日：2020-10-22
申请号：PCT/US2020/025739
申请日：2020-03-30
Inventor： WAGENER, Kenneth, B. , PRIBYL, Julia, Grace , BELL, Michael, H.
IPC: C08F4/60
Abstract: A method of carrying out a metathesis reaction includes the combination of at least one alkene or non conjugated diene with a Ruthenium-based catalyst with an cyclic(alkyl)(amino)carbene ligand to form a reaction mixture, heating the reaction mixture to a temperature of 100°C or greater in the absence of a solvent in bulk conditions, and mechanically stirring the reaction mixture. The reaction can be an ADMET, ROMP, a metathesis ring-closure or an olefin exchange reaction.
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公开(公告)号：WO2020185775A2
公开(公告)日：2020-09-17
申请号：PCT/US2020/021886
申请日：2020-03-10
Inventor： CRECY, Valerie, Anne De , HUTINET, Geoffrey, Jean
IPC: C12N7/00
Abstract: The present disclosure is directed to materials and methods for reducing heterologous DNA damage in bacteria (i.e., induce resistance to host restriction enzymes) by modifying the heterologous DNA to include one or more deazapurine bases.
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公开(公告)号：WO2020180960A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020947
申请日：2020-03-04
IPC: A01H6/28 , A61K31/352 , C12M1/34
Abstract: In one aspect, the disclosure relates to substituted axially-chiral cannabinol analogs, methods of making same, pharmaceutical compositions comprising same, and methods of treating pain using same. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present disclosure.
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公开(公告)号：WO2020168146A1
公开(公告)日：2020-08-20
申请号：PCT/US2020/018208
申请日：2020-02-14
Inventor： MADDALONI, Massimo , PASCUAL, David, Wayne
IPC: A61K31/431 , A61K45/06 , A61K31/05
Abstract: Embodiments herein include an attenuated live vaccine composition for protection against Neisseria spp . infection, the vaccine composition comprising an effective amount of Snodgras sella alvi (S. alvi ), or an antigen component thereof, and methods for treating or preventing disease related to or aggravated by Neisseria gonorrhea is provided.
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