公开(公告)号：WO2006051531A3

公开(公告)日：2006-09-28

申请号：PCT/IL2005001173

申请日：2005-11-09

Applicant: SPECTRUM DYNAMICS LLC ,  ROUSSO BENNY ,  BEN-HAIM SHLOMO ,  NAGLER MICHAEL ,  ZIV OMER ,  RAVHON RAN ,  DICKMAN DALIA ,  ZILBERSTEIN YOEL ,  DICHTERMAN ELI ,  BEN-HAIM SIMONA ,  VALLABHAJOSULA SHANKAR ,  BERMAN DANIEL ,  BRONSHTINE ZOHAR ,  POPPER ZIV ,  WEISSBERG NIR ,  ROTH NATHANIEL ,  MELMAN HAIM

Inventor： ROUSSO BENNY ,  BEN-HAIM SHLOMO ,  NAGLER MICHAEL ,  ZIV OMER ,  RAVHON RAN ,  DICKMAN DALIA ,  ZILBERSTEIN YOEL ,  DICHTERMAN ELI ,  BEN-HAIM SIMONA ,  VALLABHAJOSULA SHANKAR ,  BERMAN DANIEL ,  BRONSHTINE ZOHAR ,  POPPER ZIV ,  WEISSBERG NIR ,  ROTH NATHANIEL ,  MELMAN HAIM

IPC: A61K49/00

CPC classification number: G01T1/1615 ,  A61B5/06 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4291 ,  A61B6/488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/507 ,  A61B6/541 ,  A61B6/547 ,  A61B6/548 ,  A61B6/583 ,  A61B8/0825 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/543 ,  G01R33/481 ,  G01T1/1642 ,  G01T1/2985

Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.

Abstract translation: 放射成像方法，装置和放射性药物。

公开(公告)号：WO2007010534A2

公开(公告)日：2007-01-25

申请号：PCT/IL2006000834

申请日：2006-07-19

Applicant: SPECTRUM DYNAMICS LLC ,  ROUSSO BENNY ,  DICKMAN DALIA ,  NIR YAEL ,  NAGLER MICHAEL ,  BRONSHTINE ZOHAR ,  VALLABHAJOSULA SHANKAR ,  BEN-HAIM SHLOMO ,  BEN-HAIM SIMONA

Inventor： ROUSSO BENNY ,  DICKMAN DALIA ,  NIR YAEL ,  NAGLER MICHAEL ,  BRONSHTINE ZOHAR ,  VALLABHAJOSULA SHANKAR ,  BEN-HAIM SHLOMO ,  BEN-HAIM SIMONA

IPC: A61K51/00

CPC classification number: A61B5/02755 ,  A61B5/06 ,  A61B5/4064 ,  A61B5/4076 ,  A61B5/4088 ,  A61B5/411 ,  A61B5/415 ,  A61B5/417 ,  A61B5/418 ,  A61B5/4519 ,  A61B6/037 ,  A61B6/4057 ,  A61B6/4258 ,  A61B6/4291 ,  A61B6/4488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/503 ,  A61B6/504 ,  A61B6/507 ,  A61B6/5247 ,  A61B6/583 ,  A61B8/0891 ,  A61B8/4416 ,  A61K51/02 ,  A61K51/04 ,  A61K51/0402 ,  A61K51/0476 ,  A61K51/0478 ,  A61K51/048 ,  A61K51/0489 ,  A61K51/0491 ,  A61K51/1203

Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

Abstract translation: 提供用于放射成像事件或障碍的协议。 示例性方案包括放射成像心肌灌注的方法，该方法依次包括：（a）向受试者施用约3mCi Tl201硫酸氯化物; （b）允许所述受试者休息; （c）对所述受试者的心脏进行放射成像; （d）使所述受试者受到身体压力; （e）在所述身体应激的峰值处施用约20-30mCi Tc99m sestamibi的所述受试者; 和（f）对所述受试者的所述心脏进行放射成像，从而放射成像心肌灌注。

公开(公告)号：WO2007010534A3

公开(公告)日：2007-01-25

申请号：PCT/IL2006/000834

申请日：2006-07-19

Applicant: SPECTRUM DYNAMICS LLC ,  ROUSSO, Benny ,  DICKMAN, Dalia ,  NIR, Yael ,  NAGLER, Michael ,  BRONSHTINE, Zohar ,  VALLABHAJOSULA, Shankar ,  BEN-HAIM, Shlomo ,  BEN-HAIM, Simona

Inventor： ROUSSO, Benny ,  DICKMAN, Dalia ,  NIR, Yael ,  NAGLER, Michael ,  BRONSHTINE, Zohar ,  VALLABHAJOSULA, Shankar ,  BEN-HAIM, Shlomo ,  BEN-HAIM, Simona

IPC: A61B6/00

Abstract: Protocols for radioimaging an event or disorder are provided. An exemplary protocol comprises a method of radioimaging a myocardial perfusion, the method comprising in sequence: (a) administering to a subject about 3 mCi Tl201 thallous chloride; (b) allowing said subject to rest; (c) radioimaging a heart of said subject; (d) subjecting said subject to a physical stress; (e) administering to said subject at a peak of said physical stress about 20-30 mCi Tc99m sestamibi; and (f) radioimaging said heart of said subject, thereby radioimaging a myocardial perfusion.

公开(公告)号：WO2010096486A1

公开(公告)日：2010-08-26

申请号：PCT/US2010/024475

申请日：2010-02-17

Applicant: CORNELL RESEARCH FOUNDATION, INC. ,  BANDER, Neil ,  OSBORNE, Joseph ,  GOLDSMITH, Stanley ,  VALLABHAJOSULA, Shankar

Inventor： BANDER, Neil ,  OSBORNE, Joseph ,  GOLDSMITH, Stanley ,  VALLABHAJOSULA, Shankar

IPC: A61K51/10 ,  G01N33/60 ,  A61K103/30 ,  A61P35/00

CPC classification number: A61K51/106 ,  A61K51/0482 ,  G01N2800/52

Abstract: A method for identifying a patient for cancer therapy can include administering a diagnostic dose of a detectably labeled first binding agent to a patient, the detectably labeled binding agent being capable of binding a molecular target. The method also includes selecting a patient for administration of a therapeutic dose of a second binding agent capable of binding a cellular target, wherein the selected patient exhibits a positive reading for the detectably labeled first binding agent. Furthermore, the method can include administering a therapeutic dose of the second binding agent to the patient.

Abstract translation: 用于鉴定癌症治疗的患者的方法可以包括向患者施用诊断剂量的可检测标记的第一结合剂，所述可检测标记的结合剂能够结合分子靶。 该方法还包括选择用于施用治疗剂量的能够结合细胞靶标的第二结合剂的患者，其中所选择的患者对可检测标记的第一结合剂显示阳性读数。 此外，该方法可以包括向患者施用治疗剂量的第二结合剂。

公开(公告)号：WO2006075333A3

公开(公告)日：2006-12-14

申请号：PCT/IL2006000059

申请日：2006-01-15

Applicant: SPECTRUM DYNAMICS LLC ,  ROUSSO BENNY ,  DICKMAN DALIA ,  NAGLER MICHAEL ,  VALLABHAJOSULA SHANKAR

Inventor： ROUSSO BENNY ,  DICKMAN DALIA ,  NAGLER MICHAEL ,  VALLABHAJOSULA SHANKAR

IPC: G01T1/166

CPC classification number: A61B5/02755 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/4519 ,  A61B5/7203 ,  A61B5/7264 ,  A61B6/037 ,  A61B6/486 ,  A61B6/507 ,  G01T1/1647

Abstract: The present invention relates to the capabilities of a highly sensitive radioactive-emission camera, a result of a meticulous search for the many different effects that combine synergistically to increase sensitivity and spatial, spectral, and time resolutions. The new camera opens a new realm in SPECT-type imaging, making it viable for dynamic studies, the use of radiopharmaceutical cocktails, molecular imaging, dosimetry and other studies requiring the high sensitivity and resolutions. In particular, the new camera opens the door to SPECT expert system, examples for which are provided. The expert system relates to defining disease signatures for automatic diagnosis, preferably, based on a multi-parameter vector, preferably, based on kinetic radiopharmaceutical values. Additionally or alternatively, based on simultaneous administration of multi le isotopes

Abstract translation: 本发明涉及高灵敏度放射性发射相机的能力，这是细致搜索许多不同效果的结果，这些效果协同组合以增加灵敏度和空间，光谱和时间分辨率。 新型相机开创了SPECT型成像领域的新领域，使其适用于动态研究，放射性药物混合物的使用，分子成像，剂量测定以及其他需要高灵敏度和分辨率的研究。 特别是，新款相机为SPECT专家系统打开了大门，并提供了相关示例。 专家系统涉及定义用于自动诊断的疾病签名，优选基于多参数向量，优选基于动力学放射性药物值。 另外或可选地，基于同时施用多个同位素

公开(公告)号：WO2006051531A2

公开(公告)日：2006-05-18

申请号：PCT/IL2005/001173

申请日：2005-11-09

Applicant: SPECTRUM DYNAMICS (ISRAEL) LTD. ,  ROUSSO, Benny ,  BEN-HAIM, Shlomo ,  NAGLER, Michael ,  ZIV, Omer ,  RAVHON, Ran ,  DICKMAN, Dalia ,  ZILBERSTEIN, Yoel ,  DICHTERMAN, Eli ,  BEN-HAIM, Simona ,  VALLABHAJOSULA, Shankar ,  BERMAN, Daniel ,  BRONSHTINE, Zohar ,  POPPER, Ziv ,  WEISSBERG, Nir ,  ROTH, Nathaniel ,  MELMAN, Haim

Inventor： ROUSSO, Benny ,  BEN-HAIM, Shlomo ,  NAGLER, Michael ,  ZIV, Omer ,  RAVHON, Ran ,  DICKMAN, Dalia ,  ZILBERSTEIN, Yoel ,  DICHTERMAN, Eli ,  BEN-HAIM, Simona ,  VALLABHAJOSULA, Shankar ,  BERMAN, Daniel ,  BRONSHTINE, Zohar ,  POPPER, Ziv ,  WEISSBERG, Nir ,  ROTH, Nathaniel ,  MELMAN, Haim

IPC: F16J15/50 ,  F16J15/02

CPC classification number: A61B6/44 ,  A61B5/06 ,  A61B5/415 ,  A61B5/416 ,  A61B5/418 ,  A61B5/7285 ,  A61B6/037 ,  A61B6/0414 ,  A61B6/425 ,  A61B6/4258 ,  A61B6/4266 ,  A61B6/4275 ,  A61B6/4291 ,  A61B6/488 ,  A61B6/501 ,  A61B6/502 ,  A61B6/507 ,  A61B6/541 ,  A61B6/547 ,  A61B6/548 ,  A61B6/583 ,  A61B8/0808 ,  A61B8/0825 ,  A61B8/12 ,  A61B8/4416 ,  A61B8/543 ,  A61K51/00 ,  A61K51/0478 ,  A61K51/1048 ,  G01R33/481 ,  G01T1/1615 ,  G01T1/1642 ,  G01T1/2985

Abstract: Radioimaging methods, devices and radiopharmaceuticals therefor.

Abstract translation: 放射性成像方法，装置和放射性药物。