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    PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION
    1.
    发明申请
    PREVENTING OR REDUCING SCALE IN WET-PROCESS PHOSPHORIC ACID PRODUCTION 审中-公开
    防止或减少湿法处理磷酸生产的规模

    公开(公告)号：WO2012128755A1

    公开(公告)日：2012-09-27

    申请号：PCT/US2011/029319

    申请日：2011-03-22

    Applicant: CYTEC TECHNOLOGY CORP. ,  RAVISHANKAR, Sathanjheri ,  WANG, Bing

    Inventor： RAVISHANKAR, Sathanjheri ,  WANG, Bing

    IPC: C01B25/22

    CPC classification number: C01B25/22

    Abstract: Methods for preventing or reducing the formation of scale in a wet-process phosphoric acid production process by intermixing a scale inhibiting reagent at one or more step of the phosphoric acid production process in an amount sufficient to prevent or reduce scale are provided.

    Abstract translation: 提供了通过在磷酸生产过程的一个或多个步骤中以足以防止或减小氧化皮的量的相互混合水垢抑制试剂来防止或减少湿法磷酸生产过程中氧化皮屑形成的方法。

    COMPOSITIONS FOR ORAL AND NASAL HYGIENE
    2.
    发明申请
    COMPOSITIONS FOR ORAL AND NASAL HYGIENE 审中-公开
    口腔和鼻腔卫生组合物

    公开(公告)号：WO2012075257A3

    公开(公告)日：2012-09-20

    申请号：PCT/US2011062844

    申请日：2011-12-01

    Applicant: UNIV GEORGIA ,  WANG BING-YAN ,  ZHAO TONG ,  CIANCIO SEBASTIAN ,  DOYLE MICHAEL

    Inventor： WANG BING-YAN ,  ZHAO TONG ,  CIANCIO SEBASTIAN ,  DOYLE MICHAEL

    IPC: A61K31/401 ,  A61K31/185 ,  A61K31/19 ,  A61K31/4015 ,  A61P31/04

    CPC classification number: A61K31/19 ,  A61K8/365 ,  A61K8/463 ,  A61K9/0043 ,  A61K9/0063 ,  A61K31/185 ,  A61Q11/00 ,  A61Q17/005 ,  A61K2300/00

    Abstract: The present disclosure encompasses pharmaceutically acceptable antimicrobial compositions of an amount of levulinic acid and sodium dodecyl sulfate effective in reducing the microbial population of an internal cranial cavity of a recipient human or animal subject. The disclosure also provides methods for reducing a microbial population of an internal cranial cavity of a recipient human or animal comprising contacting the oral cavity or sinuses of the subject with a composition comprising between about 0.5% to about 5% by weight per volume of levulinic acid and between about 0.05% to about 2% by weight per volume of sodium dodecyl sulfate (SDS) and for a period effective in reducing a microbial population of the oral cavity.

    Abstract translation: 本公开内容包括一定量的乙酰丙酸和十二烷基硫酸钠的药学上可接受的抗微生物组合物，其有效减少受体人或动物受试者的内部颅腔的微生物群体。 本公开还提供了减少受体人或动物的内部颅腔的微生物群体的方法，包括使受试者的口腔或鼻窦与包含约0.5％至约5％（体积）乙酰丙酸的组合物接触 和约0.05％至约2％重量/体积的十二烷基硫酸钠（SDS），并有效降低口腔微生物群体的时间。

    CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT
    3.
    发明申请
    CRYSTALLINE (8S,9R)-5-FLUORO-8-(4-FLUOROPHENYL)-9-(1-METHYL-1H-1,2,4-TRIAZOL-5-YL)-8,9-DIHYDRO-2H-PYRIDO[4,3,2-DE]PHTHALAZIN-3(7H)-ONE TOSYLATE SALT 审中-公开
    （8S，9R）-5-氟-9-（4-氟代戊基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡喃 [4,3,2-DE]苯乙烯-3（7H） - 苯甲酸盐

    公开(公告)号：WO2012054698A1

    公开(公告)日：2012-04-26

    申请号：PCT/US2011/057039

    申请日：2011-10-20

    Applicant: BIOMARIN PHARMACEUTICAL INC. ,  WANG, Bing ,  CHU, Daniel ,  LIU, Yongbo ,  PENG, Shichun

    Inventor： WANG, Bing ,  CHU, Daniel ,  LIU, Yongbo ,  PENG, Shichun

    IPC: C07D471/06 ,  A61K31/5025 ,  A61P35/00

    CPC classification number: C07D471/06

    Abstract: Provided herein are (8 S , 9 R )-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-lH-1,2,4-triazol-5- yl)-8,9-dihydro-2 H -pyrido[4,3,2- de ]phthalazin-3(7 H )-one tosylate salt forms, including crystalline forms, and methods of their preparation. Pharmaceutical compositions comprising a (8 S ,9 R )-5-fiuoro-8-(4-fluorophenyl)-9-(1-methyl-1 H -1,2,4-triazol-5-yl)-8,9-dihydro-2 H - pyrido[4,3,2- de ]phthalazin-3(7 H )-one tosylate salt are also provided, as are methods of using (8 S ,9 R )-5-fluoro-8-(4-fluorophenyl)-9-(1-methyl-1 H -1,2,4-triazol-5-yl)-8,9-dihydro-2 H - pyrido[4,3,2- de ]phthalazin-3(7 H )-one tosylate salt to treat a disease or condition, such as a cancer.

    Abstract translation: 本文提供的是（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H- - 吡啶并[4,3,2-de]酞嗪-3（7H） - 酮甲磺酸盐形式，包括晶型，及其制备方法。 包含（8S，9R）-5-氟-8-（4-氟苯基）-9-（1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢 - 还提供了使用（8S，9R）-5-氟-8-（4-氟苯基）-9（2H） - 吡啶并[4,3,2- - （1-甲基-1H-1,2,4-三唑-5-基）-8,9-二氢-2H-吡啶并[4,3,2- [de] 2,3-二氮杂萘-3（7H） - 酮甲苯磺酸盐， 治疗疾病或病症，如癌症。

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