METHOD FOR IMPROVING WHITE MATTER INTEGRITY IN HYPERPHENYLALANINEMIA AND PHENYLKETONURIA PATIENTS
    2.
    发明申请
    METHOD FOR IMPROVING WHITE MATTER INTEGRITY IN HYPERPHENYLALANINEMIA AND PHENYLKETONURIA PATIENTS 审中-公开
    提高高胰岛素血症和苯丙酮尿症患者白质完整性的方法

    公开(公告)号:WO2017069612A1

    公开(公告)日:2017-04-27

    申请号:PCT/NL2015/050739

    申请日:2015-10-23

    Applicant: N.V. NUTRICIA

    Abstract: The invention pertains to the use of a composition in the manufacture of a productor method for therapeutically improving, promoting, restoring or maintaining white matter integrity in a subject suffering from PKU and/or in a subject suffering from or at increased risk of impaired white matter integrity associated with PKU, said composition comprising therapeutic amounts of at least one ω-3 polyunsaturated fatty acid (LCPUFA) selected from the group consisting of docosahexaenoic acid (DHA), eicosapentaenoic acid (EPA) and docosapentaenoic acid (DPA); and one of more of uridine, cytidine and/or an equivalent thereof, including salts, phosphates, acyl derivatives and/or esters. The invention also pertains to a composition for use in such use or method.

    Abstract translation: 本发明涉及组合物在制造生产方法中的用途,所述方法用于治疗性改善,促进,恢复或维持患有PKU的受试者中和/或患有 或与PKU相关的白质完整性受损风险增加,所述组合物包含治疗量的选自二十二碳六烯酸(DHA),二十碳五烯酸(EPA)和二十二碳五烯酸的至少一种ω-3多不饱和脂肪酸(LCPUFA) 酸(DPA); 和尿苷,胞苷和/或其等价物中的一种或多种,​​包括盐,磷酸盐,酰基衍生物和/或酯。 本发明还涉及用于这种用途或方法的组合物。

    OPTIMIZED NUTRIENT FATTY ACID COMPOSITION
    5.
    发明申请
    OPTIMIZED NUTRIENT FATTY ACID COMPOSITION 审中-公开
    优化的营养素脂肪酸组成

    公开(公告)号:WO2016071927A2

    公开(公告)日:2016-05-12

    申请号:PCT/IN2015/000412

    申请日:2015-11-09

    Abstract: An optimized nutrient fatty acid composition capable of using as food, skin care, hair care and media for delivery of drugs and nutrients through mucous membrane, skin and parenterally for humans, pets and farm animals, with a ratio of omega 6 fatty acid to omega 3 fatty acids ranging from 1:1 to 1:1.25 stabilized with vitamin E 0.8-4mg/ml. More specifically a stable fatty acid composition with 50-70% of the total fatty acids as essential and, or semi essential fatty acid of which 25-35% omega 3 fatty acids, 25-35% as omega 6 fatty acids and 20-30% as monounsaturated fatty acids is capable of optimization of bodily functions, maintenance of health, prevention of diseases, promotion of healing, delay aging, and treatment of diseases caused by imbalance in omega 3 and 6 fatty acid ratio in diet and nutritional support for pregnant and lactating women, growing children, senior citizens, sports persons, obese and over weight on calorie restricted diet.

    Abstract translation: 优化的营养脂肪酸组合物能够用作食品,皮肤护理,头发护理和媒介,用于通过粘膜,皮肤和肠胃外给人,宠物和农场动物递送药物和营养物, 用维生素E 0.8-4mg / ml稳定的从1:1至1:1.25范围内的Ω6脂肪酸与Ω3脂肪酸的比例。 更具体地说,含有占总脂肪酸50-70%为必需的稳定脂肪酸组合物,或者半脂肪酸,其中25-35%的ω3脂肪酸,25-35%的ω6脂肪酸和20-30% %,因为单不饱和脂肪酸能够优化身体机能,维持健康,预防疾病,促进愈合,延缓衰老,以及治疗由饮食和营养支持中的omega 3和6脂肪酸比例不平衡引起的疾病 和哺乳期妇女,成长中的儿童,老年人,运动员,肥胖和超重的热量限制饮食。

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