公开(公告)号：WO02054868A3

公开(公告)日：2003-03-27

申请号：PCT/US0150241

申请日：2001-12-21

Applicant: INHALE THERAPEUTIC SYST ,  WEICKERT MICHAEL ,  GORDON MARC S ,  KUMAR SANDEEP ,  YANG BING ,  SARWAR RAZAQ

Inventor： WEICKERT MICHAEL ,  GORDON MARC S ,  KUMAR SANDEEP ,  YANG BING ,  SARWAR RAZAQ

IPC: A61K9/12 ,  A61K9/00 ,  A61K9/16 ,  A61K31/00 ,  A61K31/7048 ,  A61K47/04 ,  A61K47/12 ,  A61K47/18 ,  A61P31/10 ,  A61K313/7048

CPC classification number: A61K9/0075 ,  A61K9/1688

Abstract: The present invention provides spray-dried polyene compositions for oral inhalation to the lung. The polyene antifungal compositions demonstrate superior aerosol properties, do not exhibit appreciable degradation of the polyene upon spray-drying, and are useful in the treatment and prophylaxis of both pulmonary and systemic fungal infections.

Abstract translation: 本发明提供用于口服吸入肺的喷雾干燥的多烯组合物。 多烯抗真菌组合物表现出优异的气溶胶性质，在喷雾干燥时不表现出多烯的显着降解，并且可用于治疗和预防肺部和全身真菌感染。

公开(公告)号：WO2012034084A3

公开(公告)日：2012-06-28

申请号：PCT/US2011051098

申请日：2011-09-09

Applicant: S E A MEDICAL SYSTEMS INC ,  MATSIEV LEONID F ,  WEICKERT MICHAEL J ,  BENNETT JAMES W ,  SMITH MATTHEW F ,  LITVINTSEVA SVETLANA ,  BLANKE KIT

Inventor： MATSIEV LEONID F ,  WEICKERT MICHAEL J ,  BENNETT JAMES W ,  SMITH MATTHEW F ,  LITVINTSEVA SVETLANA ,  BLANKE KIT

IPC: A61M5/172 ,  G01N27/06 ,  G01N27/08 ,  G01N27/416 ,  G06Q50/00

CPC classification number: G01N27/026 ,  A61M5/142 ,  A61M2205/0244 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/6018 ,  G01N27/4166 ,  Y02A90/26

Abstract: Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.

Abstract translation: 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的特性，药物的浓度以及使用导纳光谱法的稀释剂类型。 这些装置，系统和方法对于描述身份以及在一些变型中特别可用于浓缩医疗液体如静脉内液体的一种或多种组分。 特别地，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了通过模式识别来识别复合导纳光谱仪图案以确定液体的组成的方法。

公开(公告)号：WO1997004110A1

公开(公告)日：1997-02-06

申请号：PCT/US1996011600

申请日：1996-07-12

Applicant: SOMATOGEN, INC. ,  WEICKERT, Michael, J. ,  GLASCOCK, Christopher, B.

Inventor： SOMATOGEN, INC.

IPC: C12N15/63

CPC classification number: C07K14/805 ,  C12N15/63 ,  C12N15/67 ,  C12N15/70 ,  C12N15/72

Abstract: The present invention relates to host cells and methods for expressing heterologous polypeptides. The host cell comprises a high copy number plasmid encoding said polypeptide and a chromosomally-located regulator of expression of said polypeptide under control of a strong promoter.

Abstract translation: 本发明涉及宿主细胞和用于表达异源多肽的方法。 宿主细胞包含编码所述多肽的高拷贝数质粒和在强启动子控制下所述多肽表达的染色体定位调节剂。

公开(公告)号：WO2010144482A2

公开(公告)日：2010-12-16

申请号：PCT/US2010/037817

申请日：2010-06-08

Applicant: S.E.A. MEDICAL SYSTEMS, INC. ,  MATSIEV, Leonid ,  WEICKERT, Michael ,  BENNETT, James

Inventor： MATSIEV, Leonid ,  WEICKERT, Michael ,  BENNETT, James

IPC: G01N27/06 ,  G01N27/02 ,  G01N33/15

CPC classification number: A61B5/145 ,  A61B5/14557 ,  A61B5/4839 ,  A61B5/7267 ,  A61M5/172 ,  A61M2205/3523 ,  A61M2205/3592 ,  G01N27/026

Abstract: Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.

Abstract translation: 本文描述了用于确定流体组成的装置，系统和方法，特别是用于描述诸如静脉内流体的医用流体的一种或多种组分的特性和浓度。 这些装置，系统和方法从流体样品进行多重复杂的导纳测量，以便识别流体组分的特性和浓度。 可以同时快速地确定溶液的所有组分的特性和浓度。 在一些变型中，除导纳光谱外，还可以使用额外的测量或感测方式，包括光学，热学，化学等。

公开(公告)号：WO9850430A3

公开(公告)日：1999-04-01

申请号：PCT/US9808861

申请日：1998-05-01

Applicant: SOMATOGEN INC ,  UNIV RICE WILLIAM M ,  WEICKERT MICHAEL J ,  GLASCOCK CHRISTOPHER B ,  MATHEWS ANTONY J ,  LEMON DOUGLAS D ,  DOHERTY DANIEL H ,  OLSON JOHN S

Inventor： WEICKERT MICHAEL J ,  GLASCOCK CHRISTOPHER B ,  MATHEWS ANTONY J ,  LEMON DOUGLAS D ,  DOHERTY DANIEL H ,  OLSON JOHN S

IPC: C12N15/09 ,  A61K38/00 ,  C07K14/805 ,  C12N1/21 ,  C12N5/06 ,  C12N15/12 ,  C12P21/02

CPC classification number: C07K14/805 ,  A61K38/00

Abstract: The invention relates to novel recombinant hemoglobins having reduced nitric oxide scavenging and/or increased high soluble expression. The invention further relates to methods of increasing the soluble expression of recombinant hemoglobin by adding exogenous hemin in molar excess of the heme binding sites of recombinant hemoglobin.

Abstract translation: 本发明涉及具有减少的一氧化氮清除和/或增加的高可溶性表达的新型重组血红蛋白。 本发明还涉及通过在重组血红蛋白的血红素结合位点的摩尔过量中加入外源血红素来增加重组血红蛋白的可溶性表达的方法。

公开(公告)号：WO2012034084A2

公开(公告)日：2012-03-15

申请号：PCT/US2011/051098

申请日：2011-09-09

Applicant: S.E.A. MEDICAL SYSTEMS, INC. ,  MATSIEV, Leonid, F. ,  WEICKERT, Michael, J. ,  BENNETT, James, W. ,  SMITH, Matthew, F. ,  LITVINTSEVA, Svetlana ,  BLANKE, Kit

Inventor： MATSIEV, Leonid, F. ,  WEICKERT, Michael, J. ,  BENNETT, James, W. ,  SMITH, Matthew, F. ,  LITVINTSEVA, Svetlana ,  BLANKE, Kit

IPC: A61M5/172 ,  G01N27/06 ,  G01N27/08 ,  G01N27/416 ,  G06Q50/00

CPC classification number: G01N27/026 ,  A61M5/142 ,  A61M2205/0244 ,  A61M2205/3306 ,  A61M2205/3313 ,  A61M2205/3553 ,  A61M2205/3561 ,  A61M2205/6018 ,  G01N27/4166 ,  Y02A90/26

Abstract: Described herein are devices, systems, and methods for determining the composition of liquids, including the identity of one or more drugs in the liquid, the concentration of the drug, and the type of diluent using immittance spectroscopy. These devices, systems and methods are particularly useful for describing the identity and, in some variations, concentration of one or more components of a medical liquid such as intravenous fluid. In particular, described herein are devices, systems and methods that may operate in low ionic strength diluents. Also described are methods of recognizing complex immittance spectrograph patterns to determine the composition of a liquid by pattern recognition.

Abstract translation: 本文描述了用于确定液体组成的装置，系统和方法，包括液体中一种或多种药物的身份，药物的浓度和稀释剂的类型，使用导抗能谱法 。 这些装置，系统和方法对于描述身份特别有用，并且在一些变型中描述医疗液体的一种或多种组分如静脉注射液的浓度。 具体而言，本文描述了可以在低离子强度稀释剂中操作的装置，系统和方法。 还描述了识别复导抗谱仪图案以通过模式识别来确定液体组成的方法。

公开(公告)号：WO2010144482A3

公开(公告)日：2011-02-10

申请号：PCT/US2010037817

申请日：2010-06-08

Applicant: S E A MEDICAL SYSTEMS INC ,  MATSIEV LEONID ,  WEICKERT MICHAEL ,  BENNETT JAMES

Inventor： MATSIEV LEONID ,  WEICKERT MICHAEL ,  BENNETT JAMES

IPC: G01N27/06 ,  G01N27/02 ,  G01N33/15

CPC classification number: A61B5/145 ,  A61B5/14557 ,  A61B5/4839 ,  A61B5/7267 ,  A61M5/172 ,  A61M2205/3523 ,  A61M2205/3592 ,  G01N27/026

Abstract: Described herein are devices, systems, and methods for determining the composition of fluids, and particularly for describing the identity and concentration of one or more components of a medical fluid such as intravenous fluid. These devices, systems and methods take multiple complex admittance measurements from a fluid sample in order to identify the identity and the concentration of components of the fluid. The identity and concentration of all of the components of the solution may be simultaneously and rapidly determined. In some variations, additional measurement or sensing modalities may be used in addition to admittance spectroscopy, including optical, thermal, chemical, etc.

Abstract translation: 本文描述了用于确定流体组成的装置，系统和方法，特别是用于描述诸如静脉内流体的医用流体的一种或多种组分的身份和浓度。 这些装置，系统和方法从流体样品进行多重复杂的导纳测量，以便识别流体组分的特性和浓度。 可以同时快速地确定溶液的所有组分的特性和浓度。 在一些变型中，除导纳光谱外，还可以使用额外的测量或感测方式，包括光学，热学，化学等。