公开(公告)号：WO2010030678A1

公开(公告)日：2010-03-18

申请号：PCT/US2009/056375

申请日：2009-09-09

Applicant: APPLIED SYSTEMS, INC. ,  WILLIAMS, Meredith, A. ,  CRONIN, Michael, B. ,  USTINOV, Tracy, E. ,  BEAL, Matthew, R. ,  MAHAFFEY, Charles, O.

Inventor： WILLIAMS, Meredith, A. ,  CRONIN, Michael, B. ,  USTINOV, Tracy, E. ,  BEAL, Matthew, R. ,  MAHAFFEY, Charles, O.

IPC: G06F17/30

CPC classification number: G06F17/30011 ,  G06Q10/10

Abstract: A system, method, and apparatus for scanning and importing documents is disclosed. Specifically, the disclosed system provides a device for scanning documents and importing and forwarding scanned documents based on document identifiers. Documents are received and reviewed for entry into the document management system. An identifier is associated with each document based on the level of available information about the document. An identifier is assigned to each document. Each document with its assigned identifier is scanned. Documents are then imported into the document management system or forwarded to a recipient for additional review. Separator identifiers may be used to increase efficiency. Further, the system may allow certain users to use reporting functions to access information about the document management system and the recipients of documents.

Abstract translation: 公开了一种扫描和导入文件的系统，方法和装置。 具体地，所公开的系统提供了用于扫描文档并基于文档标识符导入和转发扫描的文档的设备。 收到并审查文件以进入文件管理系统。 基于关于文档的可用信息的级别，标识符与每个文档相关联。 标识符被分配给每个文档。 扫描具有其分配标识符的每个文档。 然后将文档导入到文档管理系统中，或转发给收件人以进行其他审查。 分隔符标识符可用于提高效率。 此外，系统可以允许某些用户使用报告功能来访问关于文档管理系统和文档的接收者的信息。

公开(公告)号：WO2009045174A1

公开(公告)日：2009-04-09

申请号：PCT/SG2008/000378

申请日：2008-10-03

Applicant: S*BIO PTE LTD ,  NAGARAJ, Harish, Kumar, Mysore ,  CHEN, Dizhong ,  POULSEN, Anders ,  WILLIAMS, Meredith

Inventor： NAGARAJ, Harish, Kumar, Mysore ,  CHEN, Dizhong ,  POULSEN, Anders ,  WILLIAMS, Meredith

IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00

CPC classification number: C07D473/32

Abstract: The present invention relates to purine compounds that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.

Abstract translation: 本发明涉及可用作激酶抑制剂的嘌呤化合物。 更具体地，本发明涉及嘌呤化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在增殖性疾病的治疗中的用途。 这些化合物可用作治疗许多增殖性疾病的药物，包括肿瘤和癌症以及与mTOR激酶相关或与之相关的其它病症或病症。

公开(公告)号：WO2007061661A2

公开(公告)日：2007-05-31

申请号：PCT/US2006043951

申请日：2006-11-13

Applicant: AMGEN INC ,  BIOVITRUM AB ,  HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC A ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHRISTOPHER ,  ST JEAN DAVID J JR ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBEGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J ,  MARSHALL TERESA L

Inventor： HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC A ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHRISTOPHER ,  ST JEAN DAVID J JR ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBEGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J ,  MARSHALL TERESA L

IPC: C07D277/54 ,  A61K31/426 ,  A61K31/427 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

CPC classification number: C07D277/54 ,  C07D277/60 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to thiazolinones and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-ß-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11- ß-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及噻唑啉酮以及包含该化合物的药物组合物，以及该化合物用于治疗与人类11-羟基类固醇脱氢酶1型酶有关的病症的用途的方法以及用于制备作用于 人类11-羟基类固醇脱氢酶1型酶。

公开(公告)号：WO2005075471A2

公开(公告)日：2005-08-18

申请号：PCT/SE2005/000140

申请日：2005-02-04

Applicant: BIOVITRUM AB ,  TEDENBORG, Lars ,  BARF, Tjeerd ,  NORDIN, Sofia ,  VALLGÅRDA, Jerk ,  WILLIAMS, Meredith ,  KURZ, Guido

Inventor： TEDENBORG, Lars ,  BARF, Tjeerd ,  NORDIN, Sofia ,  VALLGÅRDA, Jerk ,  WILLIAMS, Meredith ,  KURZ, Guido

IPC: C07D417/12

CPC classification number: C07D277/54 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to compounds with the formula (I), wherein R1, R2, R3, X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I）的化合物，其中R 1，R 2，R 3，X和Y如本文所定义，并且还涉及包含该化合物的药物组合物，以及该化合物在医药和 用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物。

公开(公告)号：WO2004103980A1

公开(公告)日：2004-12-02

申请号：PCT/SE2004/000792

申请日：2004-05-21

Applicant: BIOVITRUM AB ,  WILLIAMS, Meredith ,  PYRING, David ,  VÅGBERG, Jan ,  HENRIKSSON, Martin ,  NILSSON, Cecilia ,  NILSSON, Catrine

Inventor： WILLIAMS, Meredith ,  PYRING, David ,  VÅGBERG, Jan ,  HENRIKSSON, Martin ,  NILSSON, Cecilia ,  NILSSON, Catrine

IPC: C07D285/08

CPC classification number: A61K31/433 ,  A61K31/4709 ,  A61K31/5377 ,  C07D285/08 ,  C07D285/135 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to compounds with the formula (I) and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-β-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I）的化合物以及包含该化合物的药物组合物，以及该化合物在医药中的用途以及制备作用于人类11-β-羟基类固醇脱氢酶 1型酶。

公开(公告)号：WO2010114494A1

公开(公告)日：2010-10-07

申请号：PCT/SG2010/000133

申请日：2010-04-01

Applicant: S*BIO PTE LTD ,  CHEN, DiZhong ,  NAGARAJ, Harish Kumar Mysore ,  WILLIAMS, Meredith

Inventor： CHEN, DiZhong ,  NAGARAJ, Harish Kumar Mysore ,  WILLIAMS, Meredith

IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00

CPC classification number: C07D473/32

Abstract: The present invention relates to purine compounds of formula (I): that are useful as kinase inhibitors. More particularly, the present invention relates to purine compounds, methods for their preparation, pharmaceutical compositions containing these compounds and uses of these compounds in the treatment of proliferative disorders. These compounds may be useful as medicaments for the treatment of a number of proliferative disorders including tumours and cancers as well as other disorders or conditions related to or associated with mTOR kinases.

Abstract translation: 本发明涉及式（I）的嘌呤化合物：其可用作激酶抑制剂。 更具体地，本发明涉及嘌呤化合物，其制备方法，含有这些化合物的药物组合物和这些化合物在增殖性疾病的治疗中的用途。 这些化合物可用作治疗许多增殖性疾病的药物，包括肿瘤和癌症以及与mTOR激酶相关或与之相关的其它病症或病症。

公开(公告)号：WO2005116002A2

公开(公告)日：2005-12-08

申请号：PCT/US2005018081

申请日：2005-05-24

Applicant: AMGEN INC ,  BIOVITRUM AB ,  HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHIRSTOPHER ,  ST JEAN DAVID ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBERGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J

Inventor： HENRIKSSON MARTIN ,  HOMAN EVERT ,  JOHANSSON LARS ,  VALLGARDA JERK ,  WILLIAMS MEREDITH ,  BERCOT ERIC ,  FOTSCH CHRISTOPHER H ,  LI AIWEN ,  CAI GUOLIN ,  HUNGATE RANDALL W ,  YUAN CHESTER CHENGUANG ,  TEGLEY CHIRSTOPHER ,  ST JEAN DAVID ,  HAN NIANHE ,  HUANG QI ,  LIU QINGYIAN ,  BARTBERGER MICHAEL D ,  MONIZ GEORGE A ,  FRIZZLE MATTHEW J

IPC: A61K31/42 ,  A61K31/426 ,  A61P3/00 ,  A61P3/04 ,  A61P3/06 ,  A61P3/10 ,  A61P19/10 ,  A61P25/24 ,  A61P25/28 ,  A61P29/00 ,  A61P31/12 ,  C07D20060101 ,  C07D263/48 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/18

CPC classification number: C07D417/06 ,  C07D263/34 ,  C07D263/48 ,  C07D275/03 ,  C07D277/42 ,  C07D277/54 ,  C07D277/60 ,  C07D413/14 ,  C07D417/04 ,  C07D417/12 ,  C07D417/14 ,  C07D513/10 ,  C07F7/1856

Abstract: The present invention relates to compounds with the formula (I), (II), (III) or (IV): (I) (II), (III), or (IV), wherein R , R , R , R , R , R , R , X and Z are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as methods of use of the compounds for treatment of disorders associated with human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme and for the preparation of a medicament which acts on the human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I），（II），（III）或（IV）：（I）（II），（III）或（IV））的化合物，其中R 1，R 2 R 3，R 4，R 5，R 6，R 7，X 7和Z如本文所定义，并且还涉及包含该化合物的药物组合物，以及使用方法 的用于治疗与人类11-β-羟基类固醇脱氢酶1型酶相关的疾病的化合物和用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物。

公开(公告)号：WO2005075471A3

公开(公告)日：2005-10-06

申请号：PCT/SE2005000140

申请日：2005-02-04

Applicant: BIOVITRUM AB ,  TEDENBORG LARS ,  BARF TJEERD ,  NORDIN SOFIA ,  VALLGAARDA JERK ,  WILLIAMS MEREDITH ,  KURZ GUIDO

Inventor： TEDENBORG LARS ,  BARF TJEERD ,  NORDIN SOFIA ,  VALLGAARDA JERK ,  WILLIAMS MEREDITH ,  KURZ GUIDO

IPC: A61K31/427 ,  C07D277/54 ,  C07D417/02 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D277/18 ,  A61K31/426 ,  A61P3/04 ,  A61P3/10 ,  A61P31/06 ,  A61P31/08

CPC classification number: C07D277/54 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12

Abstract: The present invention relates to compounds with the formula (I), wherein R1, R2, R3, X, and Y are as defined herein, and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-beta-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I）的化合物，其中R 1，R 2，R 3，X和Y如本文所定义，并且还涉及包含所述化合物的药物组合物，以及所述化合物在医学中的用途和 用于制备作用于人类11-β-羟基类固醇脱氢酶1型酶的药物。

公开(公告)号：WO2003044000A1

公开(公告)日：2003-05-30

申请号：PCT/SE2002/002139

申请日：2002-11-22

Applicant: BIOVITRUM AB ,  WILLIAMS, Meredith ,  KURZ, Guido ,  NILSSON, Marianne ,  VALLGÅRDA, Jerk

Inventor： WILLIAMS, Meredith ,  KURZ, Guido ,  NILSSON, Marianne ,  VALLGÅRDA, Jerk

IPC: C07D285/08

CPC classification number: C07D285/08 ,  A61K31/381 ,  A61K31/433 ,  C07D231/12 ,  C07D233/56 ,  C07D249/08 ,  C07D285/135 ,  C07D333/36 ,  C07D409/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  C07D417/14

Abstract: The present invention relates to compounds with the formula (I), and also to pharmaceutical compositions comprising the compounds, as well as to the use of the compounds in medicine and for the preparation of a medicament which acts on the human 11-b-hydroxysteroid dehydrogenase type 1 enzyme.

Abstract translation: 本发明涉及具有式（I）的化合物，还涉及包含该化合物的药物组合物，以及该化合物在药物中的用途以及制备药物的用途， 对人类11-β-羟基类固醇脱氢酶1型酶的影响。

公开(公告)号：WO2010114484A1

公开(公告)日：2010-10-07

申请号：PCT/SG2009/000124

申请日：2009-04-03

Applicant: S*BIO PTE LTD ,  CHEN, DiZhong ,  WILLIAMS, Meredith

Inventor： CHEN, DiZhong ,  WILLIAMS, Meredith

IPC: C07D473/32 ,  A61K31/52 ,  A61P35/00

CPC classification number: C07D473/32 ,  A61K31/5377 ,  C07D487/04 ,  C12N9/12 ,  C12N9/1205 ,  C12Y207/01137 ,  C12Y207/11001 ,  Y02A50/401 ,  Y02A50/414

Abstract: The present invention relates to a purine compound useful as a kinase inhibitor. The compound has the structure (I) or a pharmaceutically acceptable salt thereof

Abstract translation: 本发明涉及可用作激酶抑制剂的嘌呤化合物。 该化合物具有结构（I）或其药学上可接受的盐