公开(公告)号：WO2008073424A9

公开(公告)日：2008-10-02

申请号：PCT/US2007025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY INC ,  AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

Inventor： AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

IPC: G01N21/25 ,  G01N33/52

CPC classification number: A61K9/146 ,  A61K31/33 ,  C07D225/04

Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

Abstract translation: 特别地，本文提供了固体形式的格尔德霉素类似物，包含格尔德霉素类似物和结晶抑制剂的药物组合物，制备和使用这些组合物的方法。 另外，提供了用于治疗癌症，肿瘤疾病状态和/或过度增殖性疾病的方法，以及抑制热休克蛋白90（“Hsp90”）的方法。

公开(公告)号：WO2008073424A2

公开(公告)日：2008-06-19

申请号：PCT/US2007025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY INC ,  AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

Inventor： AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

IPC: G01N21/25 ,  G01N33/52

CPC classification number: A61K9/146 ,  A61K31/33 ,  C07D225/04

Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

公开(公告)号：WO2007123511A2

公开(公告)日：2007-11-01

申请号：PCT/US2006010796

申请日：2006-03-24

Applicant: INFINITY PHARMACEUTICALS INC ,  MCGOVERN KAREN J ,  PIEN CHRISTINE S ,  WRIGHT JAMES L

Inventor： MCGOVERN KAREN J ,  PIEN CHRISTINE S ,  WRIGHT JAMES L

IPC: A61K31/58

CPC classification number: A61K31/58 ,  A61K9/0004 ,  A61K9/0019 ,  A61K9/0024

Abstract: The invention relates to a method of treating cancer. The method includes administering systemically a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, such that the concentration of the inhibitor in the blood does not vary by more than about ±30% from the average concentration, and such that the concentration remains at or below the maximum tolerated dose of the inhibitor for a time period of at least about one day.

Abstract translation: 本发明涉及一种治疗癌症的方法。 该方法包括全身性地施用治疗有效量的小分子刺猬蛋白通路抑制剂，使得血液中抑制剂的浓度不比平均浓度变化大约±30％，并且使得浓度保持在或 低于抑制剂的最大耐受剂量至少约一天的时间段。

公开(公告)号：WO2008073424A3

公开(公告)日：2008-06-19

申请号：PCT/US2007/025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY, INC. ,  AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

Inventor： AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

IPC: G01N21/25 ,  G01N33/52

Abstract: Provided herein, inter alia , are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

公开(公告)号：WO2008128063A1

公开(公告)日：2008-10-23

申请号：PCT/US2008/060063

申请日：2008-04-11

Applicant: INFINITY DISCOVERY, INC. ,  WRIGHT, James, L. ,  PORTER, James, R.

Inventor： WRIGHT, James, L. ,  PORTER, James, R.

IPC: A61K31/395 ,  A61K31/7016 ,  A61P35/00

CPC classification number: A61K31/7016 ,  A61K31/395 ,  A61K2300/00

Abstract: Pharmaceutical compositions of hydroquinone geldanamycin analogs, stabilised by compounds capable of forming hydrogen bands and uses of such compositions, are provided.

Abstract translation: 提供了通过能够形成氢带的化合物稳定的对苯二酚格尔德霉素类似物的药物组合物和这些组合物的用途。

公开(公告)号：WO2007123511A3

公开(公告)日：2007-11-01

申请号：PCT/US2006/010796

申请日：2006-03-24

Applicant: INFINITY PHARMACEUTICALS, INC. ,  MCGOVERN, Karen, J. ,  PIEN, Christine, S. ,  WRIGHT, James, L.

Inventor： MCGOVERN, Karen, J. ,  PIEN, Christine, S. ,  WRIGHT, James, L.

IPC: A01N45/00 ,  A61K31/56 ,  A61K31/38 ,  A61K31/585 ,  A61K9/00 ,  A61K9/52 ,  A61K9/22 ,  A61F13/00

Abstract: The invention relates to a method of treating cancer. The method includes administering systemically a therapeutically effective amount of a small molecule hedgehog pathway inhibitor, such that the concentration of the inhibitor in the blood does not vary by more than about ±30% from the average concentration, and such that the concentration remains at or below the maximum tolerated dose of the inhibitor for a time period of at least about one day.

公开(公告)号：WO2007009007A3

公开(公告)日：2007-05-03

申请号：PCT/US2006027113

申请日：2006-07-13

Applicant: INFINITY PHARMACEUTICALS INC ,  ADAMS JULIAN ,  BRAIN JULIA ,  GAO YUN ,  GEORGES-EVANGELINOS ASIMINA T ,  GRAYZEL DAVID ,  GRENIER LOUIS ,  NORMANT EMMANUEL ,  PAK ROGER H ,  PALOMBELLA VITO ,  PORTER JAMES R ,  TONG JEFFREY K ,  WRIGHT JAMES L

Inventor： ADAMS JULIAN ,  BRAIN JULIA ,  GAO YUN ,  GEORGES-EVANGELINOS ASIMINA T ,  GRAYZEL DAVID ,  GRENIER LOUIS ,  NORMANT EMMANUEL ,  PAK ROGER H ,  PALOMBELLA VITO ,  PORTER JAMES R ,  TONG JEFFREY K ,  WRIGHT JAMES L

IPC: A61K31/395 ,  A61P11/06 ,  A61P35/00 ,  A61P37/08 ,  C07D211/60 ,  C07D225/06 ,  C07D498/08 ,  C07F5/02 ,  C07F9/6561

CPC classification number: C07D211/60 ,  A61K31/33 ,  A61K31/395 ,  C07D225/06 ,  C07F9/6561

Abstract: The present invention provides methods for treating hyperproliferative disorders such as cancer by administering hydroquinone ansamycin compounds.

Abstract translation: 本发明提供了通过施用氢醌安莎霉素化合物治疗过度增殖性疾病如癌症的方法。

公开(公告)号：WO2007009007A2

公开(公告)日：2007-01-18

申请号：PCT/US2006/027113

申请日：2006-07-13

Applicant: INFINITY PHARMACEUTICALS, INC. ,  ADAMS, Julian ,  BRAIN, Julia ,  GAO, Yun ,  GEORGES-EVANGELINOS, Asimina, T. ,  GRAYZEL, David ,  GRENIER, Louis ,  NORMANT, Emmanuel ,  PAK, Roger, H. ,  PALOMBELLA, Vito ,  PORTER, James, R. ,  TONG, Jeffrey, K. ,  WRIGHT, James, L.

Inventor： ADAMS, Julian ,  BRAIN, Julia ,  GAO, Yun ,  GEORGES-EVANGELINOS, Asimina, T. ,  GRAYZEL, David ,  GRENIER, Louis ,  NORMANT, Emmanuel ,  PAK, Roger, H. ,  PALOMBELLA, Vito ,  PORTER, James, R. ,  TONG, Jeffrey, K. ,  WRIGHT, James, L.

IPC: C07D211/60 ,  C07D225/06 ,  C07D498/08 ,  C07F5/02 ,  C07F9/6561

CPC classification number: C07D211/60 ,  A61K31/33 ,  A61K31/395 ,  C07D225/06 ,  C07F9/6561

Abstract: The present invention provides methods for treating hyperproliferative disorders such as cancer by administering hydroquinone ansamycin compounds.

Abstract translation: 本发明提供了通过施用氢醌安沙霉素化合物来治疗过度增殖性疾病例如癌症的方法。

公开(公告)号：WO2005063714A1

公开(公告)日：2005-07-14

申请号：PCT/US2004/043162

申请日：2004-12-23

Applicant: INFINITY PHARMACEUTICALS, INC ,  ADAMS, Julian ,  GAO, Yun ,  GEORGES EVANGELINOS, Asimina, T ,  GRENIER, Louis ,  PAK, Roger, H ,  PORTER, James, R ,  WRIGHT, James, L

Inventor： ADAMS, Julian ,  GAO, Yun ,  GEORGES EVANGELINOS, Asimina, T ,  GRENIER, Louis ,  PAK, Roger, H ,  PORTER, James, R ,  WRIGHT, James, L

IPC: C07D225/06

CPC classification number: A61K31/395 ,  C07D211/60 ,  C07D225/06 ,  C07F9/6561

Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-­ammonium hydroquinone ansamycin analog.

Abstract translation: 本发明提供了含有苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病（例如癌症（式（I）和（IV））的用途。本发明提供苯醌降解的含苯醌的安莎霉素类似物 与对苯二酚反应并通过与合适的酸反应而被捕获，优选增加所得（17） - 铵氢醌安莎霉素类似物的溶解度和空气稳定性的酸。