公开(公告)号：WO2008073424A3

公开(公告)日：2008-06-19

申请号：PCT/US2007/025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY, INC. ,  AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

Inventor： AUSTAD, Brian, C. ,  GRENIER, Louis ,  HOLSON, Edward, B. ,  LEE, John, J. ,  PAK, Roger, H. ,  PORTER, James, R. ,  WRIGHT, James, L.

IPC: G01N21/25 ,  G01N33/52

Abstract: Provided herein, inter alia , are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

公开(公告)号：WO2007002093A3

公开(公告)日：2007-05-03

申请号：PCT/US2006023987

申请日：2006-06-21

Applicant: INFINITY PHARMACEUTICALS INC ,  TONG JEFFREY K ,  PORTER JAMES R

Inventor： TONG JEFFREY K ,  PORTER JAMES R

IPC: A61K31/33

CPC classification number: A61K31/33

Abstract: The present invention provides pharmaceutical compositions of reduced forms of benzoquinone-containing ansamycins, and salts thereof. The present invention also relates to the use of said pharmaceutical compositions in methods of treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract translation: 本发明提供了含有苯醌的安沙霉素的还原形式的药物组合物及其盐。 本发明还涉及所述药物组合物在治疗和调节与过度增生相关的疾病如癌症的方法中的用途。

公开(公告)号：WO2006009907A2

公开(公告)日：2006-01-26

申请号：PCT/US2005021589

申请日：2005-06-17

Applicant: INFINITY PHARMACEUTICALS INC ,  CHRISTENSEN BURTON G ,  FOLEY MICHAEL A ,  GEORGES EVANGELINOS ASIMINA T ,  LIU TAO ,  PORTER JAMES R ,  RIPKA AMY S ,  ZHANG LINPING

Inventor： CHRISTENSEN BURTON G ,  FOLEY MICHAEL A ,  GEORGES EVANGELINOS ASIMINA T ,  LIU TAO ,  PORTER JAMES R ,  RIPKA AMY S ,  ZHANG LINPING

IPC: C07D413/00

CPC classification number: C07D261/02 ,  C07D413/12

Abstract: The present invention relates to antibiotic compounds and intermediates useful in their preparation. Many of the antibiotic compounds contain a substituted isoxazolidine ring. The invention also relates to pharmaceutical compositions containing a compound of the invention. The invention further provides processes for the preparation of compounds of the invention, and methods for their use as therapeutic agents.

Abstract translation: 本发明涉及可用于其制备的抗生素化合物和中间体。 许多抗生素化合物含有取代的异恶唑烷环。 本发明还涉及含有本发明化合物的药物组合物。 本发明还提供了制备本发明化合物的方法及其用作治疗剂的方法。

公开(公告)号：WO2010045442A1

公开(公告)日：2010-04-22

申请号：PCT/US2009/060819

申请日：2009-10-15

Applicant: INFINITY DISCOVERY, INC. ,  PORTER, James, R. ,  PURI, Sonali

Inventor： PORTER, James, R. ,  PURI, Sonali

IPC: A01N43/00

CPC classification number: A61K45/06 ,  A61K9/10 ,  A61K9/19 ,  A61K9/5026 ,  A61K31/395 ,  A61K2300/00

Abstract: Aspects of the present invention provide compositions comprising a sulfur containing compound and a compound of the formula (I); and also provide methods of their preparation and use.

Abstract translation: 本发明的方面提供包含含硫化合物和式（I）化合物的组合物; 并提供其准备和使用的方法。

公开(公告)号：WO2009006042A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/067611

申请日：2008-06-20

Applicant: ALLIED MACHINE & ENGINEERING CORP. ,  LUTZ, David A. ,  PORTER, James R. ,  LYNCH, Chad M.

Inventor： LUTZ, David A. ,  PORTER, James R. ,  LYNCH, Chad M.

IPC: B23B51/00 ,  B23P15/32

CPC classification number: B23B51/06 ,  B23B29/03 ,  B23B41/02 ,  B23B51/0009 ,  B23B2251/02 ,  B23B2251/50 ,  B23B2251/68 ,  B23B2260/138 ,  Y10S408/705 ,  Y10T408/44 ,  Y10T408/45 ,  Y10T408/50 ,  Y10T408/5586 ,  Y10T408/89 ,  Y10T408/9095

Abstract: A drilling head for a tubular shank having an inside diameter and threads may comprise an axial body comprising a duct exiting through a first end; threads adjacent the first end corresponding to the threads on the shank and aligning the duct with the shank inside diameter; a bore from an outer surface of the body to the duct; and two axially extending approximately parallel and offset surfaces adjacent a second end; and an insert affixed between the offset surfaces, the insert comprising: a first face at least partially contacting one offset surface and a second face at least partially contacting the other offset surface; one or more cutting edges adjacent the first face, the second face, or both; and a cutting lip adjacent one or more cutting edges.

Abstract translation: 用于具有内径和螺纹的管状柄的钻头可以包括轴向主体，其包括通过第一端离开的管道; 与第一端相邻的螺纹对应于柄上的螺纹并将管道与柄内径对准; 从主体的外表面到管道的孔; 以及邻近第二端的两个轴向延伸的近似平行和偏移的表面; 以及插入件，其固定在所述偏移表面之间，所述插入件包括：至少部分地接触一个偏移表面的第一表面和至少部分地接触所述另一个偏移表面的第二表面; 邻近第一面，第二面或两者的一个或多个切割刃; 以及与一个或多个切削刃相邻的切削唇。

公开(公告)号：WO2008073424A9

公开(公告)日：2008-10-02

申请号：PCT/US2007025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY INC ,  AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

Inventor： AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

IPC: G01N21/25 ,  G01N33/52

CPC classification number: A61K9/146 ,  A61K31/33 ,  C07D225/04

Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

Abstract translation: 特别地，本文提供了固体形式的格尔德霉素类似物，包含格尔德霉素类似物和结晶抑制剂的药物组合物，制备和使用这些组合物的方法。 另外，提供了用于治疗癌症，肿瘤疾病状态和/或过度增殖性疾病的方法，以及抑制热休克蛋白90（“Hsp90”）的方法。

公开(公告)号：WO2008073424A2

公开(公告)日：2008-06-19

申请号：PCT/US2007025317

申请日：2007-12-11

Applicant: INFINITY DISCOVERY INC ,  AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

Inventor： AUSTAD BRIAN C ,  GRENIER LOUIS ,  HOLSON EDWARD B ,  LEE JOHN J ,  PAK ROGER H ,  PORTER JAMES R ,  WRIGHT JAMES L

IPC: G01N21/25 ,  G01N33/52

CPC classification number: A61K9/146 ,  A61K31/33 ,  C07D225/04

Abstract: Provided herein, inter alia, are solid forms of geldanamycin analogs, pharmaceutical compositions comprising a geldanamycin analog and a crystallization inhibitor, methods of making and using such compositions. Additionally, provided are methods for the treatment of cancer, a neoplastic disease state and/or a hyperproliferative disorder, and methods of inhibiting Heat Shock Protein 90 ("Hsp90").

公开(公告)号：WO2007002093A2

公开(公告)日：2007-01-04

申请号：PCT/US2006/023987

申请日：2006-06-21

Applicant: INFINITY PHARMACEUTICALS, INC. ,  TONG, Jeffrey, K. ,  PORTER, James, R.

Inventor： TONG, Jeffrey, K. ,  PORTER, James, R.

IPC: A61K38/54

CPC classification number: A61K31/33

Abstract: The present invention provides pharmaceutical compositions of reduced forms of benzoquinone-containing ansamycins, and salts thereof. The present invention also relates to the use of said pharmaceutical compositions in methods of treating and modulating disorders associated with hyperproliferation, such as cancer.

Abstract translation: 本发明提供了含苯醌的安沙霉素及其盐的还原形式的药物组合物。 本发明还涉及所述药物组合物在治疗和调节与过度增殖相关的疾病例如癌症的方法中的用途。

公开(公告)号：WO2008128063A1

公开(公告)日：2008-10-23

申请号：PCT/US2008/060063

申请日：2008-04-11

Applicant: INFINITY DISCOVERY, INC. ,  WRIGHT, James, L. ,  PORTER, James, R.

Inventor： WRIGHT, James, L. ,  PORTER, James, R.

IPC: A61K31/395 ,  A61K31/7016 ,  A61P35/00

CPC classification number: A61K31/7016 ,  A61K31/395 ,  A61K2300/00

Abstract: Pharmaceutical compositions of hydroquinone geldanamycin analogs, stabilised by compounds capable of forming hydrogen bands and uses of such compositions, are provided.

Abstract translation: 提供了通过能够形成氢带的化合物稳定的对苯二酚格尔德霉素类似物的药物组合物和这些组合物的用途。

公开(公告)号：WO2007009007A3

公开(公告)日：2007-05-03

申请号：PCT/US2006027113

申请日：2006-07-13

Applicant: INFINITY PHARMACEUTICALS INC ,  ADAMS JULIAN ,  BRAIN JULIA ,  GAO YUN ,  GEORGES-EVANGELINOS ASIMINA T ,  GRAYZEL DAVID ,  GRENIER LOUIS ,  NORMANT EMMANUEL ,  PAK ROGER H ,  PALOMBELLA VITO ,  PORTER JAMES R ,  TONG JEFFREY K ,  WRIGHT JAMES L

Inventor： ADAMS JULIAN ,  BRAIN JULIA ,  GAO YUN ,  GEORGES-EVANGELINOS ASIMINA T ,  GRAYZEL DAVID ,  GRENIER LOUIS ,  NORMANT EMMANUEL ,  PAK ROGER H ,  PALOMBELLA VITO ,  PORTER JAMES R ,  TONG JEFFREY K ,  WRIGHT JAMES L

IPC: A61K31/395 ,  A61P11/06 ,  A61P35/00 ,  A61P37/08 ,  C07D211/60 ,  C07D225/06 ,  C07D498/08 ,  C07F5/02 ,  C07F9/6561

CPC classification number: C07D211/60 ,  A61K31/33 ,  A61K31/395 ,  C07D225/06 ,  C07F9/6561

Abstract: The present invention provides methods for treating hyperproliferative disorders such as cancer by administering hydroquinone ansamycin compounds.

Abstract translation: 本发明提供了通过施用氢醌安莎霉素化合物治疗过度增殖性疾病如癌症的方法。