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1.发明申请SYNTHETIC NANOCARRIERS COMPRISING POLYMERS COMPRISING MULTIPLE IMMUNOMODULATORY AGENTS 审中-公开包含多重免疫调节剂的聚合物合成纳米颗粒
公开(公告)号：WO2013019658A2
公开(公告)日：2013-02-07
申请号：PCT/US2012/048644
申请日：2012-07-27
Applicant: SELECTA BIOSCIENCES, INC. , GAO, Yun , ALTREUTER, David, H.
Inventor： GAO, Yun , ALTREUTER, David, H.
CPC classification number: A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y02A50/386 , Y02A50/41 , Y02A50/412 , Y10T428/2982
Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise polymers that comprise at least two immunomodulatory agent moieties.
Abstract translation: 本发明涉及包含至少两种免疫调节剂部分的聚合物的合成纳米载体的组合物和相关方法。
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2.发明申请SYNTHETIC NANOCARRIER VACCINES COMPRISING PEPTIDES OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS M2E 审中-公开包含从人类流感病毒M2E获得或衍生的肽的合成纳米抗体疫苗
公开(公告)号：WO2012024632A3
公开(公告)日：2012-06-07
申请号：PCT/US2011048495
申请日：2011-08-19
Applicant: SELECTA BIOSCIENCES INC , ILYINSKII PETR , GAO YUN , LIPFORD GRAYSON B
Inventor： ILYINSKII PETR , GAO YUN , LIPFORD GRAYSON B
IPC: A61K39/145 , A61K38/16
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus M2 protein.
Abstract translation: 本发明涉及可用于免疫受试者免受流感的组合物和方法。 通常，组合物和方法包括获自或源自人流感病毒M2蛋白的肽。
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3.发明申请SYNTHETIC NANOCARRIER VACCINES COMPRISING PEPTIDES OBTAINED OR DERIVED FROM HUMAN INFLUENZA A VIRUS HEMAGGLUTININ 审中-公开包含从人类流感病毒HEMAGGLUTININ获得或衍生的肽的合成纳米颗粒疫苗
公开(公告)号：WO2012024621A2
公开(公告)日：2012-02-23
申请号：PCT/US2011/048478
申请日：2011-08-19
Applicant: SELECTA BIOSCIENCES, INC. , ILYINSKII, Petr , GAO, Yun , FU, Fen-ni , LIPFORD, Grayson, B.
Inventor： ILYINSKII, Petr , GAO, Yun , FU, Fen-ni , LIPFORD, Grayson, B.
IPC: A61K39/385 , C07K14/11 , A61K9/14 , C08G65/333 , A61P31/16 , A61P37/04 , B82Y5/00 , B82Y40/00
CPC classification number: A61K39/145 , A61K39/12 , A61K2039/55511 , A61K2039/55555 , A61K2039/6093 , C12N2760/16134 , Y10T428/2982
Abstract: This invention relates to compositions and methods that can be used immunize a subject against influenza. Generally, the compositions and methods include peptides obtained or derived from human influenza A virus hemagglutinin.
Abstract translation: 本发明涉及可用于免疫流感的受试者的组合物和方法。 通常，组合物和方法包括获自或源自人甲型流感病毒血凝素的肽。
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公开(公告)号：WO2007009007A3
公开(公告)日：2007-05-03
申请号：PCT/US2006027113
申请日：2006-07-13
Applicant: INFINITY PHARMACEUTICALS INC , ADAMS JULIAN , BRAIN JULIA , GAO YUN , GEORGES-EVANGELINOS ASIMINA T , GRAYZEL DAVID , GRENIER LOUIS , NORMANT EMMANUEL , PAK ROGER H , PALOMBELLA VITO , PORTER JAMES R , TONG JEFFREY K , WRIGHT JAMES L
Inventor： ADAMS JULIAN , BRAIN JULIA , GAO YUN , GEORGES-EVANGELINOS ASIMINA T , GRAYZEL DAVID , GRENIER LOUIS , NORMANT EMMANUEL , PAK ROGER H , PALOMBELLA VITO , PORTER JAMES R , TONG JEFFREY K , WRIGHT JAMES L
IPC: A61K31/395 , A61P11/06 , A61P35/00 , A61P37/08 , C07D211/60 , C07D225/06 , C07D498/08 , C07F5/02 , C07F9/6561
CPC classification number: C07D211/60 , A61K31/33 , A61K31/395 , C07D225/06 , C07F9/6561
Abstract: The present invention provides methods for treating hyperproliferative disorders such as cancer by administering hydroquinone ansamycin compounds.
Abstract translation: 本发明提供了通过施用氢醌安莎霉素化合物治疗过度增殖性疾病如癌症的方法。
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公开(公告)号：WO2007009007A2
公开(公告)日：2007-01-18
申请号：PCT/US2006/027113
申请日：2006-07-13
Applicant: INFINITY PHARMACEUTICALS, INC. , ADAMS, Julian , BRAIN, Julia , GAO, Yun , GEORGES-EVANGELINOS, Asimina, T. , GRAYZEL, David , GRENIER, Louis , NORMANT, Emmanuel , PAK, Roger, H. , PALOMBELLA, Vito , PORTER, James, R. , TONG, Jeffrey, K. , WRIGHT, James, L.
Inventor： ADAMS, Julian , BRAIN, Julia , GAO, Yun , GEORGES-EVANGELINOS, Asimina, T. , GRAYZEL, David , GRENIER, Louis , NORMANT, Emmanuel , PAK, Roger, H. , PALOMBELLA, Vito , PORTER, James, R. , TONG, Jeffrey, K. , WRIGHT, James, L.
IPC: C07D211/60 , C07D225/06 , C07D498/08 , C07F5/02 , C07F9/6561
CPC classification number: C07D211/60 , A61K31/33 , A61K31/395 , C07D225/06 , C07F9/6561
Abstract: The present invention provides methods for treating hyperproliferative disorders such as cancer by administering hydroquinone ansamycin compounds.
Abstract translation: 本发明提供了通过施用氢醌安沙霉素化合物来治疗过度增殖性疾病例如癌症的方法。
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Patent Agency Ranking6.发明申请ANALOGS OF BENZOQUINONE-CONTAINING ANSAMYCINS FOR THE TREATMENT OF CANCER 审中-公开用于治疗癌症的含有苯并喹酮的阿霉素类似物
公开(公告)号：WO2005063714A1
公开(公告)日：2005-07-14
申请号：PCT/US2004/043162
申请日：2004-12-23
Applicant: INFINITY PHARMACEUTICALS, INC , ADAMS, Julian , GAO, Yun , GEORGES EVANGELINOS, Asimina, T , GRENIER, Louis , PAK, Roger, H , PORTER, James, R , WRIGHT, James, L
Inventor： ADAMS, Julian , GAO, Yun , GEORGES EVANGELINOS, Asimina, T , GRENIER, Louis , PAK, Roger, H , PORTER, James, R , WRIGHT, James, L
IPC: C07D225/06
CPC classification number: A61K31/395 , C07D211/60 , C07D225/06 , C07F9/6561
Abstract: The present invention provides analogs of benzoquinone-containing ansamycins and uses thereof for treating and modulating disorders associated with hyperproliferation, such as cancer ( formula (I) and (IV). The present invention provides analogs of benzoquinone-containing ansamycins where the benzoquinone is reduced to a hydroquinone and trapped by reaction with a suitable acid, preferably ones that increase the solubility and air stability of the resulting (17)-ammonium hydroquinone ansamycin analog.
Abstract translation: 本发明提供了含有苯醌的安莎霉素类似物及其用于治疗和调节与过度增生相关的疾病（例如癌症（式（I）和（IV））的用途。本发明提供苯醌降解的含苯醌的安莎霉素类似物 与对苯二酚反应并通过与合适的酸反应而被捕获，优选增加所得（17） - 铵氢醌安莎霉素类似物的溶解度和空气稳定性的酸。
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公开(公告)号：WO2004078419A3
公开(公告)日：2004-09-16
申请号：PCT/US2004/006493
申请日：2004-03-03
Applicant: ONE WORLD TECHNOLOGIES LIMITED , ONE WORLD TECHNOLOGIES, INC. , MINALGA, Philip, F. , GAO, Yun, Hua
Inventor： MINALGA, Philip, F. , GAO, Yun, Hua
IPC: H05B37/02
Abstract: A battery-operated power tool includes housing, a motor disposed in the housing, a battery, a light source, a driver circuit, and first and second physical switches. The driver circuit includes a transistor configured as a switch connecting the battery to the light source. The driver circuit further includes a capacitor arranged to form a timer. The first physical switch is arranged such that its assertion connects the battery to the light source for a predetermined period of time. The second physical switch is separate from the first physical switch and is arranged such that its assertion connects the battery to the motor.
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8.发明申请SYNTHETIC NANOCARRIERS COMPRISING POLYMERS COMPRISING MULTIPLE IMMUNOMODULATORY AGENTS 审中-公开包含含有多种免疫调节剂的聚合物的合成纳米载体
公开(公告)号：WO2013019658A3
公开(公告)日：2013-04-25
申请号：PCT/US2012048644
申请日：2012-07-27
Applicant: SELECTA BIOSCIENCES INC , GAO YUN , ALTREUTER DAVID H
Inventor： GAO YUN , ALTREUTER DAVID H
CPC classification number: A61K39/385 , A61K39/39 , A61K47/59 , A61K47/593 , A61K47/645 , A61K2039/55555 , Y10T428/2982
Abstract: This invention relates to compositions, and related methods, of synthetic nanocarriers that comprise polymers that comprise at least two immunomodulatory agent moieties.
Abstract translation: 本发明涉及合成纳米载体的组合物和相关方法，所述合成纳米载体包含含有至少两个免疫调节剂部分的聚合物。
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9.发明申请SYNTHETIC NANOCARRIERS WITH REACTIVE GROUPS THAT RELEASE BIOLOGICALLY ACTIVE AGENTS 审中-公开具有生物活性剂的反应性组合物的合成纳米颗粒
公开(公告)号：WO2012092552A1
公开(公告)日：2012-07-05
申请号：PCT/US2011/068080
申请日：2011-12-30
Applicant: SELECTA BIOSCIENCES, INC. , ZEEP, Charles , GAO, Yun
Inventor： ZEEP, Charles , GAO, Yun
IPC: A61K39/395
CPC classification number: C08G63/912 , A61K39/39 , A61K47/593 , A61K47/6923 , A61K47/6929 , B82Y5/00 , B82Y40/00 , C07H15/252 , C08G63/08 , C12N2770/32023 , Y10T428/2989
Abstract: This invention relates to compositions, and related compounds and methods, of conjugates of synthetic nanocarriers, or components thereof, and biologically active agents, such as immunomodulatory agents, antigens, anticancer agents or antiviral agents. The biologically active agents are released from the synthetic nanocarriers in the presence of a reducing agent or by reaction with a thiol.
Abstract translation: 本发明涉及合成纳米载体或其组分的缀合物和生物活性剂如免疫调节剂，抗原，抗癌剂或抗病毒剂的组合物及相关化合物和方法。 生物活性剂在还原剂存在下或通过与硫醇反应从合成纳米载体中释放出来。
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公开(公告)号：WO2012061717A1
公开(公告)日：2012-05-10
申请号：PCT/US2011/059350
申请日：2011-11-04
Applicant: SELECTA BIOSCIENCES, INC. , ZEPP, Charles , GAO, Yun
Inventor： ZEPP, Charles , GAO, Yun
CPC classification number: B82Y5/00 , A61K39/0013 , A61K39/385 , A61K47/59 , A61K47/60 , C07D401/04 , C08G65/2609 , C08G65/2618 , C08G65/329 , C08G65/33317 , C08G65/33396 , C08G73/0206 , C08G73/0233 , C08L2203/02
Abstract: Provided herein are compounds and related composition and methods that may be raise an antibody response to nicotinic compounds, in some embodiments.
Abstract translation: 在一些实施方案中，本文提供了可能引起对烟碱化合物的抗体应答的化合物和相关组合物和方法。
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