-
1.发明申请SYSTEM FOR RAPID PRODUCTION OF HIGH-TITER AND REPLICATION-COMPETENT ADENOVIRUS-FREE RECOMBINANT ADENOVIRUS VECTORS 审中-公开用于快速生产高免和重复免疫重组腺病毒载体的系统
公开(公告)号：WO2006127956A2
公开(公告)日：2006-11-30
申请号：PCT/US2006/020350
申请日：2006-05-23
Applicant: VAXIN, INC. , TANG, De-chu, C. , ZHANG, Jianfeng , VAN KAMPEN, Kent, R.
Inventor： TANG, De-chu, C. , ZHANG, Jianfeng , VAN KAMPEN, Kent, R.
IPC: C12N15/861 , C12N7/00
CPC classification number: C12N15/86 , A61K39/12 , A61K39/145 , A61K48/0091 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2710/10351 , C12N2760/16122 , C12N2760/16134
Abstract: The present invention relates generally to the fields of gene therapy, immunology, and vaccine technology. More specifically, the invention relates to a novel system that can rapidly generate high titers of adenovirus vectors that are free of replication-competent adenovirus (RCA). Also provided are methods of generating these RCA-free adenoviral vectors, immunogenic or vaccine compositions comprising these RCA-free adenovirus vectors, methods of expressing a heterologous nucleic acid of interest in these adenovirus vectors and methods of eliciting immunogenic responses using these adenovirus vectors.
Abstract translation: 本发明一般涉及基因治疗，免疫学和疫苗技术领域。 更具体地说，本发明涉及一种可以快速产生无复制能力的腺病毒（RCA）的高滴度腺病毒载体的新系统。 还提供了产生这些无RCA的腺病毒载体的方法，包含这些无RCA的腺病毒载体的免疫原性或疫苗组合物，在这些腺病毒载体中表达感兴趣的异源核酸的方法和使用这些腺病毒载体引发免疫原性应答的方法。
-
公开(公告)号：WO2005119150A2
公开(公告)日：2005-12-15
申请号：PCT/US2005/009808
申请日：2005-03-23
Inventor： PRESCOTT, Clifford, Neal , ZHANG, Jianfeng
IPC: F25J5/00
CPC classification number: F16L59/141 , F16L7/02 , F16L59/143
Abstract: A pipe-in- pipe pipeline has a bulkhead that transfers thermal stress from an inner pipe to an outer pipe, wherein at least part of the bulkhead forms a conduit for a product traveling through the inner pipe. Most preferably, the pipeline is a cryogenic pipeline for transport of liquefied natural gas. Where desirable, insulating material may be disposed between the inner pipe and outer pipe, while spacers may maintain the distance between the pipes.
Abstract translation: 管道内管道具有将热应力从内管传递到外管的隔板，其中至少部分隔壁形成用于穿过内管的产品的导管。 最优选地，管道是用于输送液化天然气的低温管道。 如果需要，绝缘材料可以设置在内管和外管之间，而间隔件可以保持管之间的距离。
-
公开(公告)号：WO2007134125A2
公开(公告)日：2007-11-22
申请号：PCT/US2007068593
申请日：2007-05-09
Applicant: ALIBABA COM CORP , SUN TONGYU , WANG YULEI , CHAI DONG , JIANG PENG , LI ANNING , ZHANG JIANFENG , CHEN LIJUAN
Inventor： SUN TONGYU , WANG YULEI , CHAI DONG , JIANG PENG , LI ANNING , ZHANG JIANFENG , CHEN LIJUAN
IPC: G06F12/06
CPC classification number: G06Q30/08 , G06Q10/063114 , G06Q30/02 , G06Q30/0282
Abstract: Interactive resource competition ranks resource users using coefficients of performance (CoP). Resource users compete for a target resource and each offer a quantifiable reciprocal resource in exchange for using the target resource. A trigger frequency of a predetermined action with respect to the target resource is recorded, and the CoP based on the respective reciprocal resource value and the trigger frequency is determined. The target resource is then allocated based on the ranking of the CoP's. An intermediate and credit fund account is used for both making payments and recording the trigger frequency. The competition is particularly useful for allocating an information display position in online electronic marketing.
Abstract translation: 互动资源竞争使资源用户使用绩效系数（CoP）进行排名。 资源用户竞争目标资源，并且每个都提供可量化的互惠资源，以交换使用目标资源。 记录关于目标资源的预定动作的触发频率，并且确定基于相应的互惠资源值和触发频率的CoP。 然后根据CoP的排名分配目标资源。 中间和信用资金账户用于支付和记录触发频率。 比赛对于在线电子营销中分配信息显示位置特别有用。
-
公开(公告)号：WO2007134125A3
公开(公告)日：2007-11-22
申请号：PCT/US2007/068593
申请日：2007-05-09
Applicant: ALIBABA GROUP HOLDING LIMITED , SUN, Tongyu , WANG, Yulei , CHAI, Dong , JIANG, Peng , LI, Anning , ZHANG, Jianfeng , CHEN, Lijuan
Inventor： SUN, Tongyu , WANG, Yulei , CHAI, Dong , JIANG, Peng , LI, Anning , ZHANG, Jianfeng , CHEN, Lijuan
Abstract: Interactive resource competition ranks resource users using coefficients of performance (CoP). Resource users compete for a target resource and each offer a quantifiable reciprocal resource in exchange for using the target resource. A trigger frequency of a predetermined action with respect to the target resource is recorded, and the CoP based on the respective reciprocal resource value and the trigger frequency is determined. The target resource is then allocated based on the ranking of the CoP's. An intermediate and credit fund account is used for both making payments and recording the trigger frequency. The competition is particularly useful for allocating an information display position in online electronic marketing.
-
5.发明申请NOVEL TARGETS AND COMPOSITIONS FOR USE IN DECONTAMINATION, IMMUNOPROPHYLAXIS, AND POST-EXPOSURE THERAPY AGAINST ANTHRAX 审中-公开用于去蛋白，免疫抑制剂和接种治疗新药的新目标和组合物
公开(公告)号：WO2005013898A3
公开(公告)日：2006-03-30
申请号：PCT/US2004022102
申请日：2004-07-12
Applicant: VAXIN INC , HUANG CHUN-MING , ZHANG JIANFENG , TANG DE-CHU C
Inventor： HUANG CHUN-MING , ZHANG JIANFENG , TANG DE-CHU C
IPC: A61K20060101 , A61K39/07 , C07K14/32 , C07K19/00 , A61K39/02 , C12N15/31 , C12N15/70 , C12Q1/37 , C12Q1/68 , G01N33/53
CPC classification number: A61K39/07 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/552 , A61K2039/57 , C07K14/32 , C12N7/00 , C12N2710/10043
Abstract: The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds that act as specific inhibitors ofB. anthracis germination/outgrowth-associated proteins, methods and means for making such inhibitors and their use as pharmaceuticals and/or vaccines. The invention also relates to the prophylaxis and treatment of anthrax infections and, more particularly, to vaccines and compositions that comprise B. anthracisantigens, epitopes, proteins, or nucleic acid molecules, including anthrax protective antigen, anthrax lethal factor, anthrax edema factor and anthrax proteins associated with spore germination and outgrowth, as well as methods and means for making such compositions and their use as pharmaceuticals and/or vaccines.
Abstract translation: 本发明涉及炭疽芽孢的去污，预防和治疗炭疽感染，更具体地说，涉及作为B的特异性抑制剂的化合物。 炭疽芽孢/生长相关蛋白，制备这种抑制剂的方法和手段及其作为药物和/或疫苗的用途。 本发明还涉及炭疽感染的预防和治疗，更具体地涉及包含炭疽菌抗原，表位，蛋白质或核酸分子的疫苗和组合物，包括炭疽保护性抗原，炭疽致死因子，炭疽水肿因子和炭疽 与孢子萌发和生长相关的蛋白质，以及制备这些组合物的方法和方法及其作为药物和/或疫苗的用途。
-
Patent Agency Ranking6.发明申请
公开(公告)号：WO2009039242A1
公开(公告)日：2009-03-26
申请号：PCT/US2008/076794
申请日：2008-09-18
Applicant: ALIBABA GROUP HOLDING LIMITED , ZHANG, Jianfeng
Inventor： ZHANG, Jianfeng
IPC: G06Q30/00
CPC classification number: G06Q30/0246 , G06Q30/02
Abstract: A method and a system monitor the effectiveness of an online advertisement with improved accuracy. The method analyzes a request for visiting a target webpage, determines whether the request is from an advertisement website, and extracts from the request a monitored target identifier if the request is from an advertisement website. The method further obtains a user identifier according to the request, and records a tracking data containing the monitored target identifier and the user identifier. Upon occurrence of an advertisement effect monitoring event, the method finds a recorded tracking data containing the monitored target identifier and the user identifier associated with the event, and records an effective data of advertisement effect based on the tracking data and/or information of the advertisement effect monitoring event.
Abstract translation: 一种方法和系统以准确度提高在线广告的有效性。 该方法分析访问目标网页的请求，确定请求是否来自广告网站，并且如果请求来自广告网站，则从请求中提取被监视的目标标识符。 该方法还根据请求获得用户标识符，并记录包含被监视目标标识符和用户标识符的跟踪数据。 在发生广告效果监视事件时，该方法发现包含被监视目标标识符和与该事件相关联的用户标识符的记录跟踪数据，并根据广告的跟踪数据和/或信息记录广告效果的有效数据 效果监控事件。
-
公开(公告)号：WO2005119150A3
公开(公告)日：2008-04-10
申请号：PCT/US2005009808
申请日：2005-03-23
Applicant: FLUOR TECH CORP , PRESCOTT CLIFFORD NEAL , ZHANG JIANFENG
Inventor： PRESCOTT CLIFFORD NEAL , ZHANG JIANFENG
CPC classification number: F16L59/141 , F16L7/02 , F16L59/143
Abstract: A pipe-in- pipe pipeline has a bulkhead that transfers thermal stress from an inner pipe to an outer pipe, wherein at least part of the bulkhead forms a conduit for a product traveling through the inner pipe. Most preferably, the pipeline is a cryogenic pipeline for transport of liquefied natural gas. Where desirable, insulating material may be disposed between the inner pipe and outer pipe, while spacers may maintain the distance between the pipes.
Abstract translation: 管道内管道具有将热应力从内管传递到外管的隔板，其中至少部分隔壁形成用于穿过内管的产品的导管。 最优选地，管道是用于输送液化天然气的低温管道。 如果需要，绝缘材料可以设置在内管和外管之间，而间隔件可以保持管之间的距离。
-
公开(公告)号：WO2006127956A3
公开(公告)日：2007-10-18
申请号：PCT/US2006020350
申请日：2006-05-23
Applicant: VAXIN INC , TANG DE-CHU C , ZHANG JIANFENG , VAN KAMPEN KENT R
Inventor： TANG DE-CHU C , ZHANG JIANFENG , VAN KAMPEN KENT R
IPC: C12Q1/64
CPC classification number: C12N15/86 , A61K39/12 , A61K39/145 , A61K48/0091 , A61K2039/5254 , A61K2039/5256 , A61K2039/543 , C07K14/005 , C12N7/00 , C12N2710/10343 , C12N2710/10351 , C12N2760/16122 , C12N2760/16134
Abstract: The present invention relates generally to the fields of gene therapy, immunology, and vaccine technology. More specifically, the invention relates to a novel system that can rapidly generate high titers of adenovirus vectors that are free of replication-competent adenovirus (RCA). Also provided are methods of generating these RCA-free adenoviral vectors, immunogenic or vaccine compositions comprising these RCA-free adenovirus vectors, methods of expressing a heterologous nucleic acid of interest in these adenovirus vectors and methods of eliciting immunogenic responses using these adenovirus vectors.
Abstract translation: 本发明一般涉及基因治疗，免疫学和疫苗技术领域。 更具体地说，本发明涉及一种可以快速产生无复制能力的腺病毒（RCA）的高滴度腺病毒载体的新系统。 还提供了产生这些无RCA的腺病毒载体的方法，包含这些无RCA的腺病毒载体的免疫原性或疫苗组合物，在这些腺病毒载体中表达感兴趣的异源核酸的方法和使用这些腺病毒载体引发免疫原性应答的方法。
-
9.发明申请NOVEL TARGETS AND COMPOSITIONS FOR USE IN DECONTAMINATION, IMMUNOPROPHYLAXIS, AND POST-EXPOSURE THERAPY AGAINST ANTHRAX 审中-公开用于去蛋白，免疫抑制剂和接种治疗新药的新目标和组合物
公开(公告)号：WO2005013898A2
公开(公告)日：2005-02-17
申请号：PCT/US2004/022102
申请日：2004-07-12
Applicant: VAXIN, INC. , HUANG, Chun-Ming , ZHANG, JianFeng , TANG, De-Chu, C.
Inventor： HUANG, Chun-Ming , ZHANG, JianFeng , TANG, De-Chu, C.
IPC: A61K
CPC classification number: A61K39/07 , A61K2039/523 , A61K2039/5256 , A61K2039/53 , A61K2039/543 , A61K2039/552 , A61K2039/57 , C07K14/32 , C12N7/00 , C12N2710/10043
Abstract: The present invention relates to the decontamination of anthrax spores, prophylaxis and treatment of anthrax infections and, more particularly, to compounds that act as specific inhibitors of B. anthracis germination/outgrowth-associated proteins, methods and means for making such inhibitors and their use as pharmaceuticals and/or vaccines. The invention also relates to the prophylaxis and treatment of anthrax infections and, more particularly, to vaccines and compositions that comprise B. anthracis antigens, epitopes, proteins, or nucleic acid molecules, including anthrax protective antigen, anthrax lethal factor, anthrax edema factor and anthrax proteins associated with spore germination and outgrowth, as well as methods and means for making such compositions and their use as pharmaceuticals and/or vaccines.
Abstract translation: 本发明涉及炭疽孢子的净化，炭疽感染的预防和治疗，更具体地，涉及作为炭疽芽孢杆菌发芽/生长相关蛋白质的特异性抑制剂的化合物，用于制备这种抑制剂的方法和手段及其用途 作为药物和/或疫苗。 本发明还涉及炭疽感染的预防和治疗，更具体地涉及包含炭疽芽孢杆菌抗原，表位，蛋白质或核酸分子的疫苗和组合物，包括炭疽保护性抗原，炭疽致死因子，炭疽水肿因子和 与孢子萌发和生长相关的炭疽病蛋白，以及制备这些组合物的方法和手段以及它们作为药物和/或疫苗的用途。
-
10.发明申请MACH-ZEHNDER ELECTRO-OPTICAL MODULATOR CONFIGURED TO PERFORM XOR OPERATION 审中-公开MACH-ZEHNDER电光调制器配置为执行异常运行
公开(公告)号：WO2004111718A1
公开(公告)日：2004-12-23
申请号：PCT/DK2004/000417
申请日：2004-06-16
Applicant: DANMARKS TEKNISKE UNIVERSITET , ZHANG, Jianfeng
Inventor： ZHANG, Jianfeng
IPC: G02F3/00
Abstract: An electro-optical Mach-Zehnder modulator is configured to perform logic exclusive-or (XOR) or inverse exclusive-or (XNOR) operations. The invention may be applied in optical communication network components with a transmitter module used to convert electrical non-return-to-zero (NRZ) encoded signals to optical Manchester-encoded signals. The resulting optical signals are well suited for high bit rate (e.g. 40 Gb/s) operation, which needs no clock rate conversion. According to the invention, an electro-optical MZ modulator performs XOR or XNOR operations of electrical signals while simultaneously performing the electro-optical modulation of the signal onto an optical carrier signal.
Abstract translation: 电光马赫曾德调制器被配置为执行逻辑异或（XOR）或反异或（XNOR）操作。 本发明可以应用于光通信网络组件中，其中发射机模块用于将电子非归零（NRZ）编码信号转换为曼彻斯特编码的信号。 所得到的光信号非常适合于不需要时钟速率转换的高比特率（例如40Gb / s）操作。 根据本发明，电光MZ调制器执行电信号的异或运算，同时对光载波信号执行信号的电光调制。
-
-
-
-
-
-
-
-
-
Search Results
12
records
(took 0.012 seconds)
