公开(公告)号：WO2016057520A1

公开(公告)日：2016-04-14

申请号：PCT/US2015/054252

申请日：2015-10-06

Applicant: 3M INNOVATIVE PROPERTIES COMPANY

Inventor： SWAMINATHAN, Swarnalatha ,  BENNAARS-EIDEN, Assumpta A. G. ,  AHIMOU, Francois ,  FOLTZ, William, E. ,  ZHANG, Ying

IPC: A61L2/28 ,  C12M1/34

CPC classification number: A61L2/28 ,  C12M1/34 ,  C12M37/06 ,  C12Q1/22 ,  G01N31/226

Abstract: A self-contained biological sterilization indicator is provided. The self-contained biological sterilization indicator includes an outer container having at least one liquid-impermeable wall and an interior volume; a sealed, openable, liquid-impermeable inner container enclosing a predetermined volume of an aqueous medium; a dry coating that comprises i) a plurality of viable test microorganisms useful to detect exposure to an oxidative sterilant and ii) an effective amount of a sterilant-resistance modulator; and a pathway that permits vapor communication between the interior volume and an atmosphere outside the outer container. The inner container and the dry coating are disposed in the interior volume. The modulator comprises an amino acid. The effective amount causes an increase in sensitivity of the test microorganisms to the oxidative sterilant relative to an otherwise-identical dry coating that lacks the effective amount.

Abstract translation: 提供独立的生物灭菌指示剂。 独立生物灭菌指示器包括具有至少一个液体不可渗透壁和内部容积的外部容器; 密封的，可开启的，液体不可渗透的内部容器，其包围预定体积的水性介质; 干涂层，其包括i）用于检测暴露于氧化灭菌剂的多个活的试验微生物和ii）有效量的消毒剂抗性调节剂; 以及允许内部容积和外部容器外部的气氛之间的蒸气连通的路径。 内部容器和干燥涂层设置在内部容积中。 调节剂包含氨基酸。 有效量导致测试微生物相对于缺乏有效量的其它相同干涂层对氧化灭菌剂的敏感性的增加。

公开(公告)号：WO2010054033A1

公开(公告)日：2010-05-14

申请号：PCT/US2009/063330

申请日：2009-11-05

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ROBOLE, Barry, W. ,  FOLTZ, William, E.

Inventor： ROBOLE, Barry, W. ,  FOLTZ, William, E.

IPC: C12Q1/22 ,  B65B55/00 ,  A61L2/16 ,  C12M1/00 ,  A61L2/28

CPC classification number: A61L2/28 ,  C12Q1/22

Abstract: A process challenge device comprising process challenge device comprising a container defining a space within the container, wherein the space can fully contain a process indicator; and at least one pressure-actuating valve associated with the container, wherein the at least one pressure-actuating valve regulates entrance of a sterilant into and exiting of a gas and/or liquid out of the space within the container, methods of using the device and a kit including the device are disclosed.

Abstract translation: 一种过程挑战装置，其包括处理挑战装置，其包括限定所述容器内的空间的容器，其中所述空间可以完全包含过程指示器; 以及与所述容器相关联的至少一个压力致动阀，其中所述至少一个压力致动阀调节灭菌剂进入和离开所述容器内空间的气体和/或液体的入口，使用所述装置的方法 并且公开了包括该装置的套件。

公开(公告)号：WO2010054095A1

公开(公告)日：2010-05-14

申请号：PCT/US2009/063416

申请日：2009-11-05

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  FOLTZ, William, E. ,  HERRLEIN, Chad, M. ,  SCHMITZ, Joshua, M. ,  ROBOLE, Barry, W. ,  WITCHER, Kelvin, J. ,  HOLT, Paul, N.

Inventor： FOLTZ, William, E. ,  HERRLEIN, Chad, M. ,  SCHMITZ, Joshua, M. ,  ROBOLE, Barry, W. ,  WITCHER, Kelvin, J. ,  HOLT, Paul, N.

IPC: A61L2/28 ,  C12Q1/22

CPC classification number: A61L2/28

Abstract: A sterilization process challenge device comprising a first container comprising walls which define a first space within the first container; a process indicator within the first space; at least one sterilant access for a sterilant to enter the first space within the first container; wherein at least one of the walls which defines the first space is a flexible wall; and wherein the walls are impervious to the sterilant; a method of using the device; and a kit including the device are disclosed.

Abstract translation: 一种灭菌过程挑战装置，包括：第一容器，其包含限定所述第一容器内的第一空间的壁; 第一空间内的过程指示器; 消毒剂至少进入消毒剂进入第一容器内的第一空间; 其中限定所述第一空间的壁中的至少一个是柔性壁; 并且其中所述壁对所述消毒剂是不透水的; 使用该装置的方法; 并且公开了包括该装置的套件。

公开(公告)号：WO2004075932A1

公开(公告)日：2004-09-10

申请号：PCT/US2004/001301

申请日：2004-01-20

Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  WITCHER, Kelvin, J. ,  FOLTZ, William, E. ,  CHANDRAPATI, Sailaja ,  ROSENLUND, Thomas, T. ,  ASMUS, Robert, A. ,  LULICH, Ronald, G.

Inventor： WITCHER, Kelvin, J. ,  FOLTZ, William, E. ,  CHANDRAPATI, Sailaja ,  ROSENLUND, Thomas, T. ,  ASMUS, Robert, A. ,  LULICH, Ronald, G.

IPC: A61L2/28

CPC classification number: C12Q1/22 ,  A61L2/28 ,  G01N31/226

Abstract: Sterilization indicator test packs for testing the effectiveness of a sterilization procedure are provided. Both non-challenge and challenge-type test packs are disclosed. The non-challenge test packs include generally comprise a tray for holding a sterilization indicator the tray containing an elevated rim surface defining the perimeter of the tray and a recessed trough for receiving a sterilization indicator. The rim surface includes a plurality of spaced-apart grooves along its length extending through the rim to the recessed trough; a sterilization indicator within the recessed trough of the tray; and a lid that forms a plurality of channels with the grooves in the tray such that sterilant can enter the tray through the channels and contact the sterilization indicator. The challenge-type test packs generally include a tray for holding a sterilization indicator, the tray comprising a substantially planar surface, a recessed trough for receiving a sterilization indicator, and a recessed groove of a defined length and cross-sectional area extending through the recessed trough and penetrating the edge of the tray; a sterilization indicator within the recessed trough of the tray; and a lid forming a substantially sterilant-impermeable seal with the planar surface of the tray and forming a lumen path with the recessed groove in the tray.

Abstract translation: 提供了用于测试灭菌程序有效性的消毒指示器测试包。 公开了非挑战型和挑战型测试包。 非挑战测试包通常包括用于保持灭菌指示器的托盘，托盘包含限定托盘的周边的升高的边缘表面和用于接收灭菌指示器的凹槽。 边缘表面包括沿其长度的多个间隔开的槽，其延伸穿过边缘到凹槽; 在托盘的凹槽内的消毒指示器; 以及与托盘中的槽形成多个通道的盖，使得消毒剂可以通过通道进入托盘并接触灭菌指示器。 挑战型测试包通常包括用于保持灭菌指示器的托盘，托盘包括基本平坦的表面，用于接收消毒指示器的凹槽，以及限定长度和横截面积的凹槽，该凹槽延伸穿过凹陷 槽并穿过托盘的边缘; 在托盘的凹槽内的消毒指示器; 以及与托盘的平坦表面形成基本上灭菌剂不可渗透的密封件的盖子，并且与托盘中的凹槽形成管腔路径。