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    POLYISOBUTYLENE BASED PASSIVATION ADHESIVE
    2.
    发明申请
    POLYISOBUTYLENE BASED PASSIVATION ADHESIVE 审中-公开

    公开(公告)号：WO2018152062A1

    公开(公告)日：2018-08-23

    申请号：PCT/US2018/017825

    申请日：2018-02-12

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： ZHANG, Ying ,  SAHNI, Vasav ,  EVERAERTS, Albert I.

    IPC: C09J123/22 ,  C08L23/22

    Abstract: The present invention is an adhesive composition for use in passivating metallic conductors in an electronic device including at least one low molecular weight polyisobutylene polymer having a weight average molecular weight of about 75,000 or lower, at least one high molecular weight polyisobutylene polymer having a weight average molecular weight of about 120,000 or higher, and optionally, at least one tackifier. Each of the polyisobutylenes and the optional tackifier has a halogen ion content of no more than 1 ppm.

    BIOLOGICAL STERILIZATION INDICATOR WITH STERILANT RESISTANCE MODULATOR
    3.
    发明申请
    BIOLOGICAL STERILIZATION INDICATOR WITH STERILANT RESISTANCE MODULATOR 审中-公开
    生物灭菌指示剂与抗衰老调节剂

    公开(公告)号：WO2016057520A1

    公开(公告)日：2016-04-14

    申请号：PCT/US2015/054252

    申请日：2015-10-06

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY

    Inventor： SWAMINATHAN, Swarnalatha ,  BENNAARS-EIDEN, Assumpta A. G. ,  AHIMOU, Francois ,  FOLTZ, William, E. ,  ZHANG, Ying

    IPC: A61L2/28 ,  C12M1/34

    CPC classification number: A61L2/28 ,  C12M1/34 ,  C12M37/06 ,  C12Q1/22 ,  G01N31/226

    Abstract: A self-contained biological sterilization indicator is provided. The self-contained biological sterilization indicator includes an outer container having at least one liquid-impermeable wall and an interior volume; a sealed, openable, liquid-impermeable inner container enclosing a predetermined volume of an aqueous medium; a dry coating that comprises i) a plurality of viable test microorganisms useful to detect exposure to an oxidative sterilant and ii) an effective amount of a sterilant-resistance modulator; and a pathway that permits vapor communication between the interior volume and an atmosphere outside the outer container. The inner container and the dry coating are disposed in the interior volume. The modulator comprises an amino acid. The effective amount causes an increase in sensitivity of the test microorganisms to the oxidative sterilant relative to an otherwise-identical dry coating that lacks the effective amount.

    Abstract translation: 提供独立的生物灭菌指示剂。 独立生物灭菌指示器包括具有至少一个液体不可渗透壁和内部容积的外部容器; 密封的，可开启的，液体不可渗透的内部容器，其包围预定体积的水性介质; 干涂层，其包括i）用于检测暴露于氧化灭菌剂的多个活的试验微生物和ii）有效量的消毒剂抗性调节剂; 以及允许内部容积和外部容器外部的气氛之间的蒸气连通的路径。 内部容器和干燥涂层设置在内部容积中。 调节剂包含氨基酸。 有效量导致测试微生物相对于缺乏有效量的其它相同干涂层对氧化灭菌剂的敏感性的增加。

    MICRONEEDLE DEVICES AND METHODS
    4.
    发明申请
    MICRONEEDLE DEVICES AND METHODS 审中-公开
    MICRONEEDLE设备和方法

    公开(公告)号：WO2012122163A1

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/027858

    申请日：2012-03-06

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    Inventor： ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    IPC: A61K9/00 ,  A61M37/00

    CPC classification number: A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of tetracaine, ropivacaine, bupivacaine, procaine and a combination thereof; wherein the local anesthetic and dose-extending component are in a non-eutectic weight ratio, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

    Abstract translation: 一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述涂层中固体总重量的至少1重量％的量存在，并且其中所述局部麻醉剂和剂量延伸组分为非共晶重量比; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自丁卡因，罗哌卡因，布比卡因，普鲁卡因及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂和剂量延伸组分为非共晶重量比，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

    MICRONEEDLE DEVICES AND METHODS
    9.
    发明申请
    MICRONEEDLE DEVICES AND METHODS 审中-公开
    MICRONEEDLE设备和方法

    公开(公告)号：WO2012122162A1

    公开(公告)日：2012-09-13

    申请号：PCT/US2012/027857

    申请日：2012-03-06

    Applicant: 3M INNOVATIVE PROPERTIES COMPANY ,  ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    Inventor： ZHANG, Ying ,  HANSEN, Kristen J. ,  DETERMAN, Amy S.

    IPC: A61K9/00 ,  A61M37/00

    CPC classification number: A61K9/0021 ,  A61M37/0015 ,  A61M2037/0023 ,  A61M2037/0046 ,  A61M2037/0061

    Abstract: A medical device, comprising: an array of microneedles, and a coating disposed on the microneedles, wherein the coating comprises: a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the local anesthetic is present in an amount of at least 1 wt-% based upon total weight of solids in the coating, and wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001; a medical device, comprising an array of dissolvable microneedles, the microneedles comprising: a dissolvable matrix material; at least 1 wt-% of a local anesthetic selected from the group consisting of lidocaine, prilocaine, and a combination thereof; and a local anesthetic dose-extending component selected from the group consisting of alpha 1 adrenergic agonists, alpha 2 adrenergic agonists, and a combination thereof; wherein the dose-extending component/local anesthetic weight ratio is at least 0.0001, and wherein wt-% is based upon total weight of solids in all portions of the dissolvable microneedles which contain the local anesthetic; a method of extending a topically delivered local anesthetic dose in mammalian tissue using the devices; and methods of making the devices are provided.

    Abstract translation: 一种医疗装置，包括：微针阵列和设置在所述微针上的涂层，其中所述涂层包括：选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述局部麻醉剂以基于所述包衣中固体总重量的至少1重量％的量存在，并且其中所述剂量延长组分/局部麻醉剂重量比至少为0.0001; 包括可溶性微针阵列的医疗装置，所述微针包括：可溶性基质材料; 至少1重量％的选自利多卡因，丙胺卡因及其组合的局部麻醉剂; 以及选自α1肾上腺素能激动剂，α2肾上腺素能激动剂及其组合的局部麻醉剂剂量延伸组分; 其中所述剂量延伸组分/局部麻醉重量比为至少0.0001，并且其中wt％基于含有所述局部麻醉剂的可溶性微针的所有部分中固体的总重量; 使用所述装置延长哺乳动物组织中局部递送的局部麻醉剂剂量的方法; 并提供制造设备的方法。

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