公开(公告)号：WO2014143342A9

公开(公告)日：2017-05-18

申请号：PCT/US2013077487

申请日：2013-12-23

Applicant: ABBOTT LAB

Inventor： MUERHOFF SCOTT A ,  MAROHNIC CHRISTOPHER ,  BIRKENMEYER LARRY ,  PROSTKO JOHN ,  BOGDAN FELISHA ,  GUTIERREZ ROBIN

IPC: C12N15/09 ,  A61K39/00 ,  A61K39/12 ,  A61K39/38

CPC classification number: C12N9/14 ,  C07K14/005 ,  C07K2319/20 ,  C07K2319/21 ,  C12N2770/24222 ,  C12N2800/22 ,  G01N33/5767 ,  G01N2469/20

Abstract: The present disclosure relates to polypeptides, including fusions thereof, nucleic acids, vectors, host cells, immunodiagnostic reagents, kits, and immunoassays for use detecting the presence of HCV antibodies. More specifically, the present invention describes specific NS3 antigens that can be used for the detection of anti-HCV antibodies.

Abstract translation: 本公开涉及用于检测HCV抗体存在的多肽，包括其融合物，核酸，载体，宿主细胞，免疫诊断试剂，试剂盒和免疫测定。 更具体地说，本发明描述了可用于检测抗-HCV抗体的特定NS3抗原。

公开(公告)号：WO2014143343A8

公开(公告)日：2015-03-19

申请号：PCT/US2013077499

申请日：2013-12-23

Applicant: ABBOTT LAB

Inventor： ZIEMANN ROBERT ,  AHLBERG APRIL ,  HAWKSWORTH DAVID ,  TIEMAN BRYAN ,  MUERHOFF A SCOTT ,  MAROHNIC CHRISTOPHER ,  OTIS KATHY

IPC: C12P21/08 ,  A61K39/29 ,  C07K16/00 ,  C12Q1/70

CPC classification number: G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

Abstract: Monoclonal antibodies for the detection of Hepatitis C Virus (HCV) antigen are provided. The antibodies specifically immunoreactive with at least one epitope of the lipid binding domain of amino acid residues 134-171 of HCV core antigen. Immunoassay methods of using antibodies, kits and compositions comprising the antibodies for detecting HCV infection are further provided.

Abstract translation: 提供用于检测丙型肝炎病毒（HCV）抗原的单克隆抗体。 与HCV核心抗原的氨基酸残基134-171的脂质结合结构域的至少一个表位特异性免疫反应的抗体。 进一步提供了使用抗体，试剂盒和包含用于检测HCV感染的抗体的组合物的免疫测定方法。