公开(公告)号：WO2014143343A8

公开(公告)日：2015-03-19

申请号：PCT/US2013077499

申请日：2013-12-23

Applicant: ABBOTT LAB

Inventor： ZIEMANN ROBERT ,  AHLBERG APRIL ,  HAWKSWORTH DAVID ,  TIEMAN BRYAN ,  MUERHOFF A SCOTT ,  MAROHNIC CHRISTOPHER ,  OTIS KATHY

IPC: C12P21/08 ,  A61K39/29 ,  C07K16/00 ,  C12Q1/70

CPC classification number: G01N33/5767 ,  C07K16/109 ,  C07K2317/34 ,  C07K2317/56 ,  C07K2317/92 ,  G01N2333/186 ,  G01N2469/10 ,  G01N2800/52

Abstract: Monoclonal antibodies for the detection of Hepatitis C Virus (HCV) antigen are provided. The antibodies specifically immunoreactive with at least one epitope of the lipid binding domain of amino acid residues 134-171 of HCV core antigen. Immunoassay methods of using antibodies, kits and compositions comprising the antibodies for detecting HCV infection are further provided.

Abstract translation: 提供用于检测丙型肝炎病毒（HCV）抗原的单克隆抗体。 与HCV核心抗原的氨基酸残基134-171的脂质结合结构域的至少一个表位特异性免疫反应的抗体。 进一步提供了使用抗体，试剂盒和包含用于检测HCV感染的抗体的组合物的免疫测定方法。

公开(公告)号：WO03002749A3

公开(公告)日：2003-07-10

申请号：PCT/US0219958

申请日：2002-06-24

Applicant: ABBOTT LAB

Inventor： SHAH DINESH O ,  DAWSON GEORGE A ,  MUERHOFF A SCOTT ,  JIANG LILY ,  GUTIERREZ ROBIN A ,  LEARY THOMAS P ,  DESAI SURESH ,  STEWART JAMES L

IPC: G01N33/543 ,  C07K14/18 ,  C12N1/15 ,  C12N1/19 ,  C12N1/21 ,  C12N5/10 ,  C12N15/09 ,  C12P21/04 ,  G01N21/76 ,  G01N33/576 ,  C12Q1/70 ,  C07H21/02 ,  C07K17/00 ,  C12N15/74

CPC classification number: C07K14/005 ,  C12N2770/24222 ,  G01N33/5767 ,  G01N2469/10 ,  G01N2469/20

Abstract: The subject invention relates to methods for the simultaneous detection of Hepatitis C Virus (HCV) antigens as well as antibodies produced in response to HCV antigens. Furthermore, the subject invention allows one to detect antigens in the early, acute stage of infection, even prior to the development of antibodies, thereby allowing for early detection of infected blood and blood products, thus improving the safety of the blood supply.

Abstract translation: 本发明涉及同时检测丙型肝炎病毒（HCV）抗原以及响应于HCV抗原产生的抗体的方法。 此外，本发明允许在感染的早期，急性阶段即使在抗体形成之前检测抗原，由此允许早期检测受感染的血液和血液制品，从而改善血液供应的安全性。

公开(公告)号：WO0046407A9

公开(公告)日：2001-09-07

申请号：PCT/US0002982

申请日：2000-02-04

Applicant: ABBOTT LAB

Inventor： LEARY THOMAS P ,  SIMONS JOHN N ,  ERKER JAMES C ,  CHALMERS MICHELE L ,  BIRKENMEYER LARRY G ,  MUERHOFF A SCOTT ,  PILOT-MATIAS TAMI J ,  DESAI SURESH M ,  MUSHAHWAR ISA K

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/566 ,  C12N15/86

CPC classification number: C12Q1/701 ,  Y10S977/804

Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.

Abstract translation: 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。

公开(公告)号：WO0210458A8

公开(公告)日：2007-07-05

申请号：PCT/US0124480

申请日：2001-08-02

Applicant: ABBOTT LAB

Inventor： BIRKENMEYER LARRY G ,  LEARY THOMAS P ,  MUERHOFF A SCOTT ,  DESAI SURESH M ,  MUSHAHWAR ISA K

IPC: C07H21/02 ,  G01N33/53 ,  C07H21/04 ,  C12M1/34 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  G01N33/566

CPC classification number: C12Q1/6809 ,  C12Q2525/131 ,  C12Q2521/501

Abstract: The subject invention relates to improvements in nucleic acid isolation, and more particularly, relates to modifications to the subtractive hybridization method and to reagents such as oligonucleotides that are useful when performing the method. The present invention provides a modified subtractive hybridization method termed Selectively Primed Adaptive Driver-RDA ("SPAD-RDA"), which utlises a driver-versus-driver subtraction control performed in parallel with the driver-versus-tester subtraction step. The products of the driver control subtraction from each round can be used as the driver of the subsequent round.

Abstract translation: 本发明涉及核酸分离的改进，更具体地涉及减法杂交方法的修饰以及在进行该方法时有用的诸如寡核苷酸的试剂。 本发明提供了一种称为选择性引发自适应驱动器-RDA（“SPAD-RDA”）的修正的减法杂交方法，其利用与驱动器对测试仪减法步骤并行执行的驱动器与驱动器的减法控制。 驾驶员从每轮减速的乘积可以作为后续轮次的驾驶员。

公开(公告)号：WO0210458A3

公开(公告)日：2003-09-04

申请号：PCT/US0124480

申请日：2001-08-02

Applicant: ABBOTT LAB

Inventor： BIRKENMEYER LARRY G ,  LEARY THOMAS P ,  MUERHOFF A SCOTT ,  DESAI SURESH M ,  MUSHAHWAR ISA K

IPC: G01N33/53 ,  C07H21/02 ,  C07H21/04 ,  C12M1/34 ,  C12N15/09 ,  C12P19/34 ,  C12Q1/68 ,  G01N33/566

CPC classification number: C12Q1/6809 ,  C12Q2525/131 ,  C12Q2521/501

Abstract: The subject invention relates to improvements in nucleic acid isolation, and more particularly, relates to modifications to the subtractive hybridization method and to reagents such as oligonucleotides that are useful when performing the method. The present invention provides a modified subtractive hybridization method termed Selectively Primed Adaptive Driver-RDA ("SPAD-RDA"), which utlises a driver-versus-driver subtraction control performed in parallel with the driver-versus-tester subtraction step. The products of the driver control subtraction from each round can be used as the driver of the subsequent round.

Abstract translation: 本发明涉及核酸分离的改进，更具体地涉及减法杂交方法的修饰以及在进行该方法时有用的诸如寡核苷酸的试剂。 本发明提供了一种称为选择性引发自适应驱动器-RDA（“SPAD-RDA”）的修正的减法杂交方法，其利用与驱动器对测试仪减法步骤并行执行的驱动器与驱动器的减法控制。 驾驶员控制从每轮减速的乘积可以作为后轮的驾驶员使用。

公开(公告)号：WO0046407A3

公开(公告)日：2002-05-10

申请号：PCT/US0002982

申请日：2000-02-04

Applicant: ABBOTT LAB

Inventor： LEARY THOMAS P ,  SIMONS JOHN N ,  ERKER JAMES C ,  CHALMERS MICHELE L ,  BIRKENMEYER LARRY G ,  MUERHOFF A SCOTT ,  PILOT-MATIAS TAMI J ,  DESAI SURESH M ,  MUSHAHWAR ISA K

IPC: G01N33/53 ,  C12N1/15 ,  C12N1/19 ,  C12N5/10 ,  C12N15/09 ,  C12Q1/68 ,  C12Q1/70 ,  G01N33/566 ,  C12N15/86

CPC classification number: C12Q1/701 ,  Y10S977/804

Abstract: The present invention relates to nucleic oligomer primers or probes useful for detection of TTV in test samples. Also provided are assays which utilize these primers and probes, as well as test kits which contain these oligomer primers and/or probes. In addition, the present invention encompasses the use of TTV nucleotide sequences as nucleic acid vectors and as markers for determining transmission between individuals as well as the route thereof. Additionally, the present invention encompasses a method of detecting TTV infection prior to xenotransplantation of a tissue or organ.

Abstract translation: 本发明涉及用于在测试样品中检测TTV的核酸低聚物引物或探针。 还提供了利用这些引物和探针的测定法，以及含有这些寡聚体引物和/或探针的测试试剂盒。 此外，本发明包括TTV核苷酸序列作为核酸载体的用途以及用于确定个体间传播的标记及其途径。 此外，本发明包括在组织或器官的异种移植之前检测TTV感染的方法。