公开(公告)号：WO2012149145A3

公开(公告)日：2013-01-10

申请号：PCT/US2012035193

申请日：2012-04-26

Applicant: ADLYFE INC ,  FEUERSTEIN GIORA ,  CLIFF RICHARD

Inventor： FEUERSTEIN GIORA ,  CLIFF RICHARD

IPC: G01N33/68 ,  A61B5/00

CPC classification number: A61K49/0056 ,  A61B3/12 ,  A61B5/4088 ,  A61K49/0021 ,  A61K49/006 ,  G01N33/6896 ,  G01N2800/2821

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract translation: 描述了使用可以非侵入性地完成蛋白质聚集体或错误折叠的蛋白质的肽或肽模拟物探针来检测个体眼睛中的蛋白质聚集体或与疾病相关的其他错误折叠的蛋白质的方法。

公开(公告)号：WO2012149145A9

公开(公告)日：2013-02-21

申请号：PCT/US2012035193

申请日：2012-04-26

Applicant: ADLYFE INC ,  FEUERSTEIN GIORA ,  CLIFF RICHARD

Inventor： FEUERSTEIN GIORA ,  CLIFF RICHARD

IPC: G01N33/68 ,  A61B5/00

CPC classification number: A61K49/0056 ,  A61B3/12 ,  A61B5/4088 ,  A61K49/0021 ,  A61K49/006 ,  G01N33/6896 ,  G01N2800/2821

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract translation: 描述了用个体眼睛检测蛋白质聚集体或与疾病相关的其他错误折叠蛋白质的方法，所述蛋白质使用肽或肽模拟物探针优先与蛋白质聚集体或错误折叠的蛋白质相关联，这可以非侵入性地完成。