公开(公告)号：WO1997035856A1

公开(公告)日：1997-10-02

申请号：PCT/US1997005820

申请日：1997-03-24

Applicant: SMITHKLINE BEECHAM CORPORATION ,  FEUERSTEIN, Giora, Z.

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: C07D401/04

CPC classification number: A61K31/5377 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/4545 ,  A61K31/506

Abstract: Use of 1,4,5-substituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.

Abstract translation: 使用1,4,5-取代的咪唑化合物和组合物治疗CNS对脑的损伤。

公开(公告)号：WO1994012177A1

公开(公告)日：1994-06-09

申请号：PCT/US1993011597

申请日：1993-12-01

Applicant: SMITHKLINE BEECHAM CORPORATION ,  BARONE, Frank, C. ,  FEUERSTEIN, Giora ,  YUE, Tian-Li

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: A61K31/40

CPC classification number: A61K31/40

Abstract: A new antioxidant cardioprotective use and method of treatment using hydroxycarbazole compounds of pharmaceutically acceptable salts thereof is disclosed. The new use and method of treatment using the antioxidant compounds prevents oxidative tissue damage to organs, particularly the central nervous system, including the brain, and particularly stroke in mammals afflicted with disease-induced ischemic trauma.

Abstract translation: 公开了一种新的抗氧化剂心脏保护用途和使用其药学上可接受的盐的羟基咔唑化合物的治疗方法。 使用抗氧化剂化合物的新用途和治疗方法防止对患有疾病引起的缺血性创伤的哺乳动物的器官，特别是中枢神经系统，包括脑的氧化组织损伤，特别是中风。

公开(公告)号：WO2012149145A3

公开(公告)日：2013-01-10

申请号：PCT/US2012035193

申请日：2012-04-26

Applicant: ADLYFE INC ,  FEUERSTEIN GIORA ,  CLIFF RICHARD

Inventor： FEUERSTEIN GIORA ,  CLIFF RICHARD

IPC: G01N33/68 ,  A61B5/00

CPC classification number: A61K49/0056 ,  A61B3/12 ,  A61B5/4088 ,  A61K49/0021 ,  A61K49/006 ,  G01N33/6896 ,  G01N2800/2821

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract translation: 描述了使用可以非侵入性地完成蛋白质聚集体或错误折叠的蛋白质的肽或肽模拟物探针来检测个体眼睛中的蛋白质聚集体或与疾病相关的其他错误折叠的蛋白质的方法。

公开(公告)号：WO2004017909A3

公开(公告)日：2004-08-19

申请号：PCT/US0326337

申请日：2003-08-21

Applicant: SQUIBB BRISTOL MYERS CO ,  WANG XINKANG ,  SCHIEVEN GARY ,  FEUERSTEIN GIORA Z

Inventor： WANG XINKANG ,  SCHIEVEN GARY ,  FEUERSTEIN GIORA Z

IPC: A61K20060101 ,  A61K39/395 ,  A61K48/00 ,  C07H21/04 ,  C12N9/12 ,  G01N33/50 ,  G01N33/68

CPC classification number: G01N33/5041 ,  C12N9/1205 ,  G01N33/6893 ,  G01N2333/91215

Abstract: The present invention includes methods of reducing the activity, such as enzymatic activity and expression, of mitogen-activated protein kinase-activated protein kinase 2. The present invention further includes methods for identifying compounds useful for reducing such activity, and methods for reducing ischemic injury by the administration of such compounds.

Abstract translation: 本发明包括降低有丝分裂原活化蛋白激酶活化蛋白激酶2的活性，如酶活性和表达的方法。本发明还包括鉴定可用于降低此类活性的化合物的方法，以及减少缺血性损伤的方法 通过这种化合物的给药。

公开(公告)号：WO2004017909A2

公开(公告)日：2004-03-04

申请号：PCT/US2003/026337

申请日：2003-08-21

Applicant: BRISTOL-MYERS SQUIBB COMPANY ,  WANG, Xinkang ,  SCHIEVEN, Gary ,  FEUERSTEIN, Giora, Z.

Inventor： WANG, Xinkang ,  SCHIEVEN, Gary ,  FEUERSTEIN, Giora, Z.

IPC: A61K

CPC classification number: G01N33/5041 ,  C12N9/1205 ,  G01N33/6893 ,  G01N2333/91215

Abstract: The present invention includes methods of reducing the activity, such as enzymatic activity and expression, of mitogen-activated protein kinase-activated protein kinase 2. The present invention further includes methods for identifying compounds useful for reducing such activity, and methods for reducing ischemic injury by the administration of such compounds.

Abstract translation: 本发明包括降低促分裂原活化蛋白激酶活化的蛋白激酶2的活性（例如酶活性和表达）的方法。本发明进一步包括鉴定可用于降低这种活性的化合物的方法 活性以及通过施用这些化合物来减少缺血性损伤的方法。

公开(公告)号：WO1998007321A1

公开(公告)日：1998-02-26

申请号：PCT/US1997014792

申请日：1997-08-22

Applicant: BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM CORPORATION LIMITED PARTNERSHIP NO. 1 ,  FEUERSTEIN, Giora, Zeev ,  YUE, Tian-Li

Inventor： BOEHRINGER MANNHEIM PHARMACEUTICALS CORPORATION-SMITHKLINE BEECHAM CORPORATION LIMITED PARTNERSHIP NO. 1

IPC: A01N43/38

CPC classification number: A61K31/40 ,  A61K31/403

Abstract: The present invention provides a method for inhibiting the expression of Fas which comprises administering to a mammal in need thereof an effective amount of a compound which is a dual non-selective beta -adrenoceptor and alpha 1-adrenoceptor antagonist.

Abstract translation: 本发明提供一种抑制Fas表达的方法，其包括向有需要的哺乳动物施用有效量的双重非选择性β-肾上腺素能受体和α1-肾上腺素受体拮抗剂的化合物。

公开(公告)号：WO1993020822A1

公开(公告)日：1993-10-28

申请号：PCT/US1993003347

申请日：1993-04-08

Applicant: SMITHKLINE BEECHAM CORPORATION ,  FEUERSTEIN, Giora, Z.

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: A61K31/55

CPC classification number: A61K31/55 ,  A61K31/44

Abstract: Invented is a method of treating Interleukin-2 induced lung injury in a mammal, including human, which comprises administering to such mammal an effective amount of a platelet-activating factor antagonist.

Abstract translation: 发明的是一种治疗哺乳动物（包括人）中白细胞介素-2诱导的肺损伤的方法，其包括对此类哺乳动物施用有效量的血小板活化因子拮抗剂。

公开(公告)号：WO2012149145A2

公开(公告)日：2012-11-01

申请号：PCT/US2012/035193

申请日：2012-04-26

Applicant: ADLYFE, INC. ,  FEUERSTEIN, Giora ,  CLIFF, Richard

Inventor： FEUERSTEIN, Giora ,  CLIFF, Richard

IPC: A61K49/00

CPC classification number: A61K49/0056 ,  A61B3/12 ,  A61B5/4088 ,  A61K49/0021 ,  A61K49/006 ,  G01N33/6896 ,  G01N2800/2821

Abstract: Described are methods for the detection, in the eye of an individual, of protein aggregates or other misfolded proteins associated with disease using peptide or peptide mimic probes that preferentially associate with the protein aggregates or misfolded proteins, which can be accomplished non-invasively.

Abstract translation: 描述了使用可以非侵入性地完成蛋白质聚集体或错误折叠的蛋白质的肽或肽模拟物探针来检测个体眼睛中的蛋白质聚集体或与疾病相关的其他错误折叠的蛋白质的方法。

公开(公告)号：WO1997040680A1

公开(公告)日：1997-11-06

申请号：PCT/US1997007037

申请日：1997-04-25

Applicant: SMITHKLINE BEECHAM CORPORATION ,  FEUERSTEIN, Giora, Z. ,  LYSKO, Paul, G.

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: A01N43/38

CPC classification number: A61K31/4045

Abstract: A new antioxidant use of, and method of treatment using, a compound of Formula (I) or a pharmaceutically acceptable salt thereof.

Abstract translation: 使用式（I）化合物或其药学上可接受的盐的新的抗氧化剂用途和治疗方法。

公开(公告)号：WO1997035855A1

公开(公告)日：1997-10-02

申请号：PCT/US1997004702

申请日：1997-03-24

Applicant: SMITHKLINE BEECHAM CORPORATION ,  FEUERSTEIN, Giora, Z.

Inventor： SMITHKLINE BEECHAM CORPORATION

IPC: C07D401/04

CPC classification number: A61K31/506 ,  A61K31/4164 ,  A61K31/4439

Abstract: Use of 2,4,5-substituted imidazole compounds and compositions in the treatment of CNS injuries to the brain.

Abstract translation: 使用2,4,5-取代的咪唑化合物和组合物治疗CNS对脑的损伤。