公开(公告)号：WO2014145108A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/029790

申请日：2014-03-14

Applicant: ADVANCED CELL TECHNOLOGY, INC.

Inventor： LANZA, Robert, P. ,  LU, Shi-Jiang ,  WANG, Wei

IPC: C12N5/074 ,  A61K35/12

CPC classification number: A61K35/545 ,  A61K35/30 ,  C12N5/0606 ,  C12N5/062 ,  C12N5/0623 ,  C12N5/0696 ,  C12N2500/33 ,  C12N2501/105 ,  C12N2501/13 ,  C12N2501/155 ,  C12N2501/235 ,  C12N2501/33 ,  C12N2501/385 ,  C12N2506/02

Abstract: Methods are provided for the production of photoreceptor cells and photoreceptor progenitor cells from pluripotent stem cells. Additionally provided are compositions of photoreceptor cells and photoreceptor cells, as well as methods for the therapeutic use thereof. Exemplary methods may produce substantially pure cultures of photoreceptor cells and/or photoreceptor cells.

Abstract translation: 提供了用于从多能干细胞产生感光细胞和感光祖细胞的方法。 另外提供感光细胞和感光细胞的组合物，以及其治疗用途的方法。 示例性的方法可以产生感光细胞和/或感光细胞的基本上纯的培养物。

公开(公告)号：WO2014100779A1

公开(公告)日：2014-06-26

申请号：PCT/US2013/077334

申请日：2013-12-21

Applicant: ADVANCED CELL TECHNOLOGY, INC.

Inventor： FENG, Qiang ,  LU, Shi-jiang ,  LANZA, Robert, P.

IPC: A61K35/14 ,  A61K35/12 ,  A61K38/36

CPC classification number: A61K35/19 ,  C12N5/0644 ,  C12N2501/04 ,  C12N2501/20 ,  C12N2501/2306 ,  C12N2501/2309 ,  C12N2501/2311 ,  C12N2501/30 ,  C12N2501/40 ,  C12N2501/727 ,  C12N2501/734 ,  C12N2501/91 ,  C12N2506/11 ,  Y02A50/411

Abstract: Methods for production of platelets from pluripotent stem cells, such as human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) are provided. These methods may be performed without forming embryoid bodies or clusters of pluripotent stem cells, and may be performed without the use of stromal inducer cells. Additionally, the yield and/or purity can be greater than has been reported for prior methods of producing platelets from pluripotent stem cells. Also provided are compositions and pharmaceutical preparations comprising platelets, preferably produced from pluripotent stem cells.

Abstract translation: 提供了从多能干细胞（例如人胚胎干细胞（hESC））和诱导的多能干细胞（iPSCs）产生血小板的方法。 这些方法可以在不形成胚状体或多能干细胞簇的情况下进行，并且可以在不使用间质诱导细胞的情况下进行。 此外，产量和/或纯度可以大于从多能干细胞产生血小板的现有方法报道的产率和/或纯度。 还提供了包含血小板的组合物和药物制剂，优选由多能干细胞产生。

公开(公告)号：WO2002078449A2

公开(公告)日：2002-10-10

申请号：PCT/US2002/010163

申请日：2002-04-02

Applicant: ADVANCED CELL TECHNOLOGY, INC. ,  LANZA, Robert, P. ,  WEST, Michael, D.

Inventor： LANZA, Robert, P. ,  WEST, Michael, D.

IPC: A01N63/00

CPC classification number: C12N5/0606 ,  A61K35/12 ,  C12N2502/1394 ,  C12N2502/28

Abstract: The invention is concerned with producing differentiated cells, tissues and organs from pluripotent and multipotent cells. The methods of the invention are particularly useful for producing differentiated cells from pluripotent cells wherein communication between the cells of more than one embryonic germ layer or more than one organ system are required for development along a specific cell lineage. The invention methods are effected by in vivo or in vitro culturing of embryonic and developing or developed allogeneic or xenogeneic cells.

Abstract translation: 本发明涉及从多能细胞和多能细胞产生分化的细胞，组织和器官。 本发明的方法特别可用于从多能细胞产生分化的细胞，其中需要多于一个胚胎胚层或更多个器官系统的细胞之间的连通以沿特定细胞谱系发育。 本发明方法通过体外或体外培养胚胎和发育或发育的同种异体或异种细胞来实现。