公开(公告)号：WO2017078622A1

公开(公告)日：2017-05-11

申请号：PCT/SG2016/050535

申请日：2016-10-31

Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

Inventor： YANG, Yi Yan ,  XU, Qingxing ,  KHAN, Majad ,  YANG, Chuan ,  VENKATARAMAN, Shrinivas

IPC: C08G73/02 ,  A01N33/12 ,  A61K31/785

CPC classification number: C08G73/02 ,  A01N33/12 ,  A01N37/44 ,  A01N43/32 ,  A61K47/59

Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.

Abstract translation: 本发明涉及包含颗粒核心的抗菌聚合物改性颗粒，其中聚合物通过接头共价结合到颗粒核心，并且所述聚合物包含具有胺的支化两亲阳离子聚亚烷基亚胺主链 或氨基官能团，并且其中任选地所述聚合物的全部或一些胺或氨基已经进一步与形成氨基甲酸酯键时带有季铵基团的两亲性环状碳酸酯反应。 在一个优选实施方案中，核是用聚亚烷基亚胺官能化的二氧化硅核。 本发明还涉及制造这种颗粒的方法及其在水消毒应用中的用途。