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    FUNCTIONAL CATIONIC DERIVATIVES OF SACCHARIDES AS ANTIMICROBIAL AGENTS
    2.
    发明申请
    FUNCTIONAL CATIONIC DERIVATIVES OF SACCHARIDES AS ANTIMICROBIAL AGENTS 审中-公开
    作为抗微生物剂的糖脂的功能性阳离子衍生物

    公开(公告)号：WO2017099668A1

    公开(公告)日：2017-06-15

    申请号：PCT/SG2016/050593

    申请日：2016-12-07

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： YANG, Yi Yan ,  VENKATARAMAN, Shrinivas ,  LEE, Ashlynn L.

    IPC: C08B31/00 ,  C08F8/44 ,  A61L15/28

    CPC classification number: A61L15/28 ,  A61L15/44 ,  A61L2300/208 ,  C08B31/125 ,  C08F8/44 ,  C08L3/02

    Abstract: A method for synthesizing a derivative of a saccharide such as starch, substituted with quaternary ammonium cations, forming a cationic polysaccharide. The method comprises subjecting a saccharide to a mixture of an optionally substituted halo-epoxide such as epichlorohydrin and one or more optionally substituted amines. The method may be prepared in a one-pot synthesis via the formation of a glycidyl derivative of a tertiary amine as an in situ intermediate. The starch polymers formed are biodegradable, have antimicrobial properties and can be further formed into antimicrobial hydrogels by photo-crosslinking of the starch derivative.

    Abstract translation: 合成被季铵阳离子取代的糖类如淀粉衍生物的方法，形成阳离子多糖。 该方法包括使糖进入任选取代的卤代环氧化物如表氯醇和一种或多种任选取代的胺的混合物。 该方法可以通过形成叔胺的缩水甘油基衍生物作为原位中间体在一锅合成中制备。 所形成的淀粉聚合物是可生物降解的，具有抗微生物性质，并且可通过淀粉衍生物的光交联进一步形成抗微生物水凝胶。

    NANOPARTICLE
    4.
    发明申请
    NANOPARTICLE 审中-公开

    公开(公告)号：WO2019059850A1

    公开(公告)日：2019-03-28

    申请号：PCT/SG2018/050486

    申请日：2018-09-25

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  IHI CORPORATION

    Inventor： YANG, Yi Yan ,  LIU, Shaoqiong ,  VOO, Zhi Xiang ,  YANG, Chuan ,  KE, Xiyu ,  GAO, Shujun ,  VENKATARAMAN, Shrinivas ,  LEE, Ashlynn ,  SATO, Hiroshi ,  EGUCHI, Haruki, ,  HARA, Masakazu

    IPC: A61K9/10 ,  A61K47/10 ,  C08G64/18 ,  C08L69/00 ,  B82Y5/00 ,  A61K31/337

    Abstract: The present invention relates to polycarbonate-based diblock polymers, nanoparticles comprising the diblock polymers and a therapeutic agent, in particular the therapeutic agent is attached to a magnetic moiety, and methods to prepare the diblock polymers and nanoparticles. Said diblock polymer comprises: (i) a first block polymer comprising of a polyether repeating unit; and (ii) a second block polymer comprising of a repeating unit of a general Formula I wherein (a) R 1 , R 2 , R 3 , R 4 , and R 5 is each independently selected from the group comprising: hydrogen, halogen, alkyl group comprising 1 to 20 carbon atoms, and aryl group comprising 6 to 20 carbon atoms, (b) p and q is each independently an integer from 0 to 6, wherein p and q cannot both be 0, (c) A is a linker, and (d) B is an aromatic moiety with two adjacent hydroxyl groups, for example catechol moiety. In a preferred embodiment, the nanoparticles encapsulated with iron-salen complexed paclitaxel are formed for use in breast cancer treatment.

    ANTIBACTERIAL PARTICLES FUNCTIONALIZED WITH POLYALKYLENE IMINE AND ITS DERIVATIVES FOR WATER DISINFECTION
    6.
    发明申请
    ANTIBACTERIAL PARTICLES FUNCTIONALIZED WITH POLYALKYLENE IMINE AND ITS DERIVATIVES FOR WATER DISINFECTION 审中-公开
    聚烷基亚胺及其衍生物用于水消毒的抗菌颗粒

    公开(公告)号：WO2017078622A1

    公开(公告)日：2017-05-11

    申请号：PCT/SG2016/050535

    申请日：2016-10-31

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： YANG, Yi Yan ,  XU, Qingxing ,  KHAN, Majad ,  YANG, Chuan ,  VENKATARAMAN, Shrinivas

    IPC: C08G73/02 ,  A01N33/12 ,  A61K31/785

    CPC classification number: C08G73/02 ,  A01N33/12 ,  A01N37/44 ,  A01N43/32 ,  A61K47/59

    Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.

    Abstract translation: 本发明涉及包含颗粒核心的抗菌聚合物改性颗粒，其中聚合物通过接头共价结合到颗粒核心，并且所述聚合物包含具有胺的支化两亲阳离子聚亚烷基亚胺主链 或氨基官能团，并且其中任选地所述聚合物的全部或一些胺或氨基已经进一步与形成氨基甲酸酯键时带有季铵基团的两亲性环状碳酸酯反应。 在一个优选实施方案中，核是用聚亚烷基亚胺官能化的二氧化硅核。 本发明还涉及制造这种颗粒的方法及其在水消毒应用中的用途。

    COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
    7.
    发明申请
    COMPOSITE HYDROGELS FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS 审中-公开
    用于输送生物活性材料的复合水凝胶

    公开(公告)号：WO2014042921A1

    公开(公告)日：2014-03-20

    申请号：PCT/US2013/057977

    申请日：2013-09-04

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： COADY, Daniel, J. ,  DIPIETRO, Richard, A. ,  ENGLER, Amanda, C. ,  HEDRICK, James, L. ,  LEE, Ashlynn, L. ,  VENKATARAMAN, Shrinivas ,  YANG, Yi, Yan

    IPC: A61K9/06 ,  A61K47/30

    CPC classification number: C08J3/075 ,  A61K9/06 ,  A61K9/1075 ,  A61K47/34 ,  C08G63/183 ,  C08J2369/00

    Abstract: A composite hydrogel comprises an amphiphilic triblock copolymer (ABA) and a loaded micelle bound by noncovalent interactions. The loaded micelle comprises a biologically active substance and an amphiphilic diblock copolymer (CD). The A blocks comprise a steroidal repeat unit (repeat unit 1) having both a backbone carbonate and a side chain bearing a steroid functional group. Each of the A blocks has a degree of polymerization of about 0.5 to about 4.0. The B block comprises a first poly(alkylene oxide) backbone. The C block comprises a second poly(alkylene oxide) backbone. The D block comprises a steroidal repeat unit (repeat unit 2) having both a backbone carbonate group and a side chain comprising a steroid functional group. The composite hydrogel is capable of controlled release of the biologically active substance.

    Abstract translation: 复合水凝胶包含两亲性三嵌段共聚物（ABA）和由非共价相互作用结合的负载胶束。 负载的胶束包含生物活性物质和两亲二嵌段共聚物（CD）。 A块包含具有骨架碳酸酯和支持类固醇官能团的侧链的甾体重复单元（重复单元1）。 每个A嵌段具有约0.5至约4.0的聚合度。 B嵌段包含第一聚（环氧烷）主链。 C嵌段包含第二聚（环氧烷）主链。 D块包含具有骨架碳酸酯基团和包含类固醇官能团的侧链的甾体重复单元（重复单元2）。 复合水凝胶能够控制释放生物活性物质。

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