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    NANOPARTICLE
    1.
    发明申请
    NANOPARTICLE 审中-公开

    公开(公告)号：WO2019059850A1

    公开(公告)日：2019-03-28

    申请号：PCT/SG2018/050486

    申请日：2018-09-25

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH ,  IHI CORPORATION

    Inventor： YANG, Yi Yan ,  LIU, Shaoqiong ,  VOO, Zhi Xiang ,  YANG, Chuan ,  KE, Xiyu ,  GAO, Shujun ,  VENKATARAMAN, Shrinivas ,  LEE, Ashlynn ,  SATO, Hiroshi ,  EGUCHI, Haruki, ,  HARA, Masakazu

    IPC: A61K9/10 ,  A61K47/10 ,  C08G64/18 ,  C08L69/00 ,  B82Y5/00 ,  A61K31/337

    Abstract: The present invention relates to polycarbonate-based diblock polymers, nanoparticles comprising the diblock polymers and a therapeutic agent, in particular the therapeutic agent is attached to a magnetic moiety, and methods to prepare the diblock polymers and nanoparticles. Said diblock polymer comprises: (i) a first block polymer comprising of a polyether repeating unit; and (ii) a second block polymer comprising of a repeating unit of a general Formula I wherein (a) R 1 , R 2 , R 3 , R 4 , and R 5 is each independently selected from the group comprising: hydrogen, halogen, alkyl group comprising 1 to 20 carbon atoms, and aryl group comprising 6 to 20 carbon atoms, (b) p and q is each independently an integer from 0 to 6, wherein p and q cannot both be 0, (c) A is a linker, and (d) B is an aromatic moiety with two adjacent hydroxyl groups, for example catechol moiety. In a preferred embodiment, the nanoparticles encapsulated with iron-salen complexed paclitaxel are formed for use in breast cancer treatment.

    POLYMER FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
    2.
    发明申请
    POLYMER FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS 审中-公开

    公开(公告)号：WO2019004932A1

    公开(公告)日：2019-01-03

    申请号：PCT/SG2018/050249

    申请日：2018-05-23

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH (A*STAR)

    Inventor： YANG, Yi Yan ,  YANG, Chuan ,  CHENG, Wei ,  LEE, Ashlynn

    IPC: C08G73/02 ,  C08F8/00 ,  C08K5/372 ,  C08K5/17 ,  A61K47/34 ,  C12N15/87

    Abstract: The present invention mainly relates to a polymer for delivery of biologically active materials, a complex and a method of synthesis thereof. The polymer comprises a poly(ethylene imine) and at least one monomer, each monomer comprising a modified sugar moiety, preferably galactose, comprising a sulphur atom or a nitrogen atom and a chemical moiety comprising a terminal epoxide for linking the polyethylene imine to the monomer, wherein the sulphur atom or the nitrogen atom links the modified sugar moiety to the chemical moiety. The biologically active material is preferably a gene, siRNA, mRNA, or plasmid DNA. Further disclosed is the medical use of said complex in treating a disease caused by a genetic disorder, for example cancer.

    ANTIBACTERIAL PARTICLES FUNCTIONALIZED WITH POLYALKYLENE IMINE AND ITS DERIVATIVES FOR WATER DISINFECTION
    3.
    发明申请
    ANTIBACTERIAL PARTICLES FUNCTIONALIZED WITH POLYALKYLENE IMINE AND ITS DERIVATIVES FOR WATER DISINFECTION 审中-公开
    聚烷基亚胺及其衍生物用于水消毒的抗菌颗粒

    公开(公告)号：WO2017078622A1

    公开(公告)日：2017-05-11

    申请号：PCT/SG2016/050535

    申请日：2016-10-31

    Applicant: AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： YANG, Yi Yan ,  XU, Qingxing ,  KHAN, Majad ,  YANG, Chuan ,  VENKATARAMAN, Shrinivas

    IPC: C08G73/02 ,  A01N33/12 ,  A61K31/785

    CPC classification number: C08G73/02 ,  A01N33/12 ,  A01N37/44 ,  A01N43/32 ,  A61K47/59

    Abstract: This invention relates to an antibacterial polymer-modified particle comprising a particle core, wherein a polymer is covalently bound to the particle core via a linker and said polymer comprises a branched, amphiphilic cationic polyalkylene imine backbone having amine or amino functional groups and wherein optionally all or some of the amine or amino groups of the polymer have been further reacted with amphiphilic cyclic carbonates carrying a quaternary ammonium group under formation of a urethane bond. In a preferred embodiment the core is a silica core functionalized with the polyelkyleneimine. The invention also relates to methods of making such particles and their use in water disinfection applications.

    Abstract translation: 本发明涉及包含颗粒核心的抗菌聚合物改性颗粒，其中聚合物通过接头共价结合到颗粒核心，并且所述聚合物包含具有胺的支化两亲阳离子聚亚烷基亚胺主链 或氨基官能团，并且其中任选地所述聚合物的全部或一些胺或氨基已经进一步与形成氨基甲酸酯键时带有季铵基团的两亲性环状碳酸酯反应。 在一个优选实施方案中，核是用聚亚烷基亚胺官能化的二氧化硅核。 本发明还涉及制造这种颗粒的方法及其在水消毒应用中的用途。

    BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS
    4.
    发明申请
    BRANCHED POLYAMINES FOR DELIVERY OF BIOLOGICALLY ACTIVE MATERIALS 审中-公开
    用于交付生物活性材料的分支聚氨酯

    公开(公告)号：WO2014042920A1

    公开(公告)日：2014-03-20

    申请号：PCT/US2013/057976

    申请日：2013-09-04

    Applicant: INTERNATIONAL BUSINESS MACHINES CORPORATION ,  AGENCY FOR SCIENCE, TECHNOLOGY AND RESEARCH

    Inventor： CHENG, Wei ,  COADY, Daniel, J. ,  ENGLER, Amanda, C. ,  HEDRICK, James, L. ,  TEO, Pei, Yun ,  YANG, Chuan ,  YANG, Yi, Yan

    IPC: C08G73/02 ,  A61K47/48 ,  A61K48/00

    CPC classification number: C12N15/85 ,  C08G73/028

    Abstract: A branched polyamine comprises about 45 to about 70 backbone tertiary amine groups, about 90 to about 140 backbone secondary amine groups, a positive number n' greater than 0 of backbone terminating primary amine groups, and a positive number q greater than 0 of backbone terminating carbamate groups of formula (2): — CH2-CH2-N— Is. ^O-L'-O H (2), wherein (n'+q) is a number equal to about 45 to about 70, the starred bond of formula (2) is linked to a backbone nitrogen of the branched polyamine, L' is a divalent radical comprising 3 to 30 carbons, and q/(n' + q) x 100% equals about 9% to about 47%.

    Abstract translation: 支链多胺包括约45至约70个主要叔胺基团，约90至约140个骨架仲胺基团，正数n'大于0的主链终止伯胺基团，正数q大于0的骨架终止 式（2）的氨基甲酸酯基团：-CH 2 -CH 2 -N-。 其中（n'+ q）为等于约45至约70的数，式（2）的星形键连接至支链多胺的主链氮，L' 是包含3至30个碳的二价基团，q /（n'+ q）x 100％等于约9％至约47％。

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