公开(公告)号：WO2022115400A1

公开(公告)日：2022-06-02

申请号：PCT/US2021/060447

申请日：2021-11-23

Applicant: AMGEN INC.

Inventor： BAUCOM, Kyle D. ,  CORBETT, Michael T. ,  CUI, Sheng ,  LANGILLE, Neil F. ,  ROTHELI, Andreas Rene ,  PROFETA, Roberto ,  SMITH, Austin G.

IPC: C07C67/14 ,  C07C67/293 ,  C07C69/16 ,  C07C69/78 ,  C07D513/10 ,  B01J31/28

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound IA, wherein R1 is described herein. Compound IA can be useful in synthesizing compound A1, or a salt or solvate thereof, and compound A2, or a salt of solvate thereof.

公开(公告)号：WO2021226009A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/030548

申请日：2021-05-04

Applicant: AMGEN INC.

Inventor： SMITH, Austin G. ,  CORBETT, Michael T. ,  LANGILLE, Neil Fred ,  BAUCOM, Kyle D. ,  DORNAN, Peter K. ,  ST-PIERRE, Gabrielle ,  ROOSEN, Philipp C. ,  CUI, Sheng ,  PROFETA, Roberto

IPC: C07D249/18 ,  C07C69/16 ,  C07C69/78 ,  C07C309/23 ,  C07D513/08 ,  C07D513/10

Abstract: Provided herein are processes for synthesizing intermediates useful in preparing Mcl-1 inhibitors. In particular, provided herein are processes for synthesizing compound F, or a salt thereof, wherein R1 and OPG2 are described herein. Compound F can be useful in synthesizing compound A1, or a salt of solvate thereof, and compound A2, or a salt of solvate thereof.