公开(公告)号：WO2020036940A1

公开(公告)日：2020-02-20

申请号：PCT/US2019/046319

申请日：2019-08-13

Applicant: AMGEN INC. ,  CARMOT THERAPEUTICS, INC.

Inventor： BUTLER, John R. ,  ERLANSON, Daniel ,  GRACEFFA, Russell ,  IWIG, Jeffrey ,  JEONG, Joon Won ,  WHITE, Ryan D. ,  WU, Yongwei ,  YI, Shuyan ,  BANERJEE, Abhisek ,  MCFARLAND, Jesse M. ,  ZHENG, Xiao Mei

IPC: C07D487/08 ,  A61K31/407 ,  A61P25/00 ,  A61K31/403

Abstract: The present invention provides a compound of formula (I) or a pharmacuetically acceptable salt thereof, pharmaceutical compositions comprising a compound of the invention, a method for manufacturing compounds of the invention and therapeutic uses thereof.

公开(公告)号：WO2021226135A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/030719

申请日：2021-05-04

Applicant: AMGEN INC. ,  VIGIL NEUROSCIENCE, INC.

Inventor： CZABANIUK, Lara C. ,  HOPPER, Timothy ,  HOUZE, Jonathan B. ,  RESCOURIO, Gwenaella ,  SANTORA, Vincent ,  WANG, Haoxuan ,  WHITE, Ryan D. ,  WONG, Alice R. ,  WU, Yongwei

IPC: A61K31/517 ,  A61P25/16 ,  A61P25/28 ,  C07D471/04

Abstract: The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).

公开(公告)号：WO2015129926A1

公开(公告)日：2015-09-03

申请号：PCT/JP2015/056584

申请日：2015-02-27

Applicant: TEIJIN PHARMA LIMITED ,  AMGEN INC.

Inventor： BECK, Hilary Plake ,  BOOKER, Shon Keith ,  BREGMAN, Howard ,  CEE, Victor J. ,  CHAKKA, Nagasree ,  CUSHING, Timothy D. ,  EPSTEIN, Oleg ,  FOX, Brian M. ,  GEUNS-MEYER, Stephanie ,  HAO, Xiaolin ,  HIBIYA, Kenta ,  HIRATA, Jun ,  HUA, Zihao ,  HUMAN, Jason ,  KAKUDA, Shinji ,  LOPEZ, Patricia ,  NAKAJIMA, Ryota ,  OKADA, Kazuhisa ,  OLSON, Steven H. ,  OONO, Hiroyuki ,  PENNINGTON, Lewis D. ,  SASAKI, Kosuke ,  SHIMADA, Keiko ,  SHIN, Youngsook ,  WHITE, Ryan D. ,  WURZ, Ryan P. ,  YI, Shuyan ,  ZHENG, Xiao Mei

IPC: C07D403/12 ,  C07D401/14 ,  C07D405/14 ,  C07D231/14 ,  C07D401/12 ,  C07D405/12 ,  C07D409/12 ,  C07D417/14 ,  C07D493/08 ,  A61K31/4155 ,  A61P29/00

CPC classification number: C07D231/14 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D405/14 ,  C07D409/12 ,  C07D413/12 ,  C07D417/14 ,  C07D493/08

Abstract: The present invention relates to a novel compound having a function of inhibiting RORγ activity. The present invention also relates to pharmaceutical composition comprising the compound, a use of the compound in treating or preventing autoimmune diseases, inflammatory diseases, metabolic diseases, or cancer diseases.

Abstract translation: 本发明涉及具有抑制RORγ活性的新型化合物。 本发明还涉及包含该化合物的药物组合物，该化合物在治疗或预防自身免疫疾病，炎性疾病，代谢疾病或癌症疾病中的用途。

公开(公告)号：WO2021226629A1

公开(公告)日：2021-11-11

申请号：PCT/US2021/070507

申请日：2021-05-04

Applicant: AMGEN INC. ,  VIGIL NEUROSCIENCE, INC.

Inventor： CZABANIUK, Lara, C. ,  HOPPER, Timothy ,  HOUZE, Jonathan, B. ,  PANTELEEV, Jane ,  RESCOURIO, Gwenaella ,  SANTORA, Vincent ,  WANG, Haoxuan ,  WHITE, Ryan D. ,  WONG, Alice, R. ,  WU, Yongwei ,  BOS, Maxence ,  MANCUSO, John ,  FRANZONI, Ivan

IPC: A61K31/5375 ,  C07D239/72 ,  C07D265/28 ,  C07D243/34 ,  A61K31/517 ,  C07H19/22 ,  A61K31/47

Abstract: The present disclosure provides compounds of Formula (I), useful for the activation of Triggering Receptor Expressed on Myeloid Cells 2 ("TREM2"). This disclosure also provides pharmaceutical compositions comprising the compounds, uses of the compounds, and compositions for treatment of, for example, a neurodegenerative disorder. Further, the disclosure provides intermediates useful in the synthesis of compounds of Formula (I).