公开(公告)号：WO2021188769A

公开(公告)日：2021-09-23

申请号：PCT/US2021/022912

申请日：2021-03-18

申请人： ARCUS BIOSCIENCES, INC. [US]/[US]

发明人： BEATTY, Joel Worley ,  DREW, Samuel Lawrie ,  EPPLIN, Matthew ,  FOURNIER, Jeremy Thomas Andre ,  GAL, Balint ,  GUNEY, Tezcan ,  HAELSIG, Karl T. ,  HARDMAN, Clayton ,  JACOB, Steven Donald ,  JEFFREY, Jenna Leigh ,  KALISIAK, Jaroslaw ,  LAWSON, Kenneth Victor ,  LELETI, Manmohan Reddy ,  LINDSEY, Erick Allen ,  MAILYAN, Artur Karenovich ,  MANDAL, Debashis ,  MATA, Guillaume ,  MOON, Hyunyoung ,  POWERS, Jay Patrick ,  ROSEN, Brandon Reid ,  SU, Yongli ,  TRAN, Anh Thu ,  WANG, Zhang ,  YAN, Xuelei ,  YU, Kai

IPC分类号： C07C255/52 ,  C07C317/14 ,  C07C317/22 ,  C07D209/34 ,  C07D213/26 ,  A61P35/00 ,  C07D213/30 ,  C07D213/61 ,  C07D213/64 ,  C07D213/71 ,  C07D213/73 ,  C07D213/74 ,  C07D213/84 ,  C07D215/18 ,  C07D215/36 ,  C07D215/48 ,  C07D217/02 ,  C07D231/12 ,  C07D231/14 ,  C07D231/56 ,  C07D237/20 ,  C07D239/28 ,  C07D239/42 ,  C07D241/12 ,  C07D241/20 ,  C07D249/06 ,  C07D249/08 ,  C07D263/32 ,  C07D263/56 ,  C07D265/36 ,  C07D277/24 ,  C07D277/40 ,  C07D277/56 ,  C07D277/62 ,  C07D307/83 ,  C07D307/88 ,  C07D311/58 ,  C07D401/04 ,  C07D409/04 ,  C07D413/04 ,  C07D471/04 ,  C07D487/04 ,  A61K31/44

摘要： Compounds that inhibit HIF-2a, and compositions containing the compound(s) and methods for synthesizing the compounds, are described herein. Also described are the use of such compounds and compositions for the treatment of a diverse array of diseases disorders, and conditions, including cancer- and immune-related disorders that are mediated, at least in part, by HIF-2a.