公开(公告)号：WO2019104034A1

公开(公告)日：2019-05-31

申请号：PCT/US2018/062005

申请日：2018-11-20

Applicant: ARIMA GENOMICS, INC.

Inventor： SELVARAJ, Siddarth ,  SCHMITT, Anthony ,  REID, Bret

IPC: C12N15/10 ,  C12Q1/6806 ,  C12Q1/6869

CPC classification number: C12N15/1065 ,  C12N15/1075 ,  C12N15/1093 ,  C12Q1/6806 ,  C12Q1/6869 ,  C12Q2535/122 ,  C12Q2563/179 ,  C12Q2563/159 ,  C12Q2565/514 ,  C12Q2523/101 ,  C12Q2563/149

Abstract: Provided herein are methods and compositions for preparing nucleic acid templates wherein spatial- proximal and molecular contiguity of target nucleic acids is preserved, and the sequencing data obtained therefrom is used, but not limited to, identification of genomic variants, determination of contiguity information to inform assemblies of target nucleic acids de novo including deconvolution of haplotype phase information, and analyses of conformation and topology of target nucleic acids.

公开(公告)号：WO2020236851A1

公开(公告)日：2020-11-26

申请号：PCT/US2020/033666

申请日：2020-05-19

Applicant: ARIMA GENOMICS, INC.

Inventor： SCHMITT, Anthony ,  SELVARAJ, Siddarth ,  REID, Bret ,  MAC, Stephen ,  ZHOU, Xiang

IPC: C12Q1/6806

Abstract: Provided herein are methods and compositions for preparing sequencing templates that provide uniform genome coverage and preserve spatial-proximal contiguity information.