公开(公告)号：WO2017180904A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027472

申请日：2017-04-13

Applicant: ARIZONA BOARD OF REGENTS on behalf of THE UNIVERSITY OF ARIZONA

Inventor： SCHWARTZ, Jacob ,  MOINPOUR, Mahta

IPC: C07K14/435 ,  C07K14/47 ,  G01N33/68 ,  G01N33/53

CPC classification number: G01N33/533 ,  C07K1/1136 ,  C07K1/13 ,  G01N33/52 ,  G01N33/57484 ,  G01N33/582 ,  G01N33/60 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6896

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as a protein misfolding disease (proteopathy).

Abstract translation: 用于检测分子聚集，折叠或相互作用的方法，系统和组合物，其特征在于将测试样品中感兴趣的分子如蛋白质的标记量与 对照，例如其中感兴趣的分子变性的样品。 如果与对照样品相比，测试样品中存在较少的标记，则测试样品可以包含聚集形式，折叠形式或交互形式的感兴趣分子，例如与另一种分子如蛋白质分子，DNA分子相互作用 或RNA分子。 本发明可用于检测或监测诸如蛋白质错误折叠疾病（蛋白质病）的疾病或病症。

公开(公告)号：WO2017180911A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027485

申请日：2017-04-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： SCHWARTZ, Jacob ,  MOINPOUR, Mahta

IPC: G01N33/53 ,  G01N33/52 ,  G01N33/68

CPC classification number: G01N33/533 ,  C07K1/1136 ,  C07K1/13 ,  G01N33/52 ,  G01N33/57484 ,  G01N33/582 ,  G01N33/60 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6896

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule. The present invention may be used for detecting or monitoring a disease or condition such as amyotrophic lateral sclerosis (ALS).

Abstract translation: 用于检测分子聚集，折叠或相互作用的方法，系统和组合物，其特征在于将测试样品中感兴趣的分子如蛋白质的标记量与 对照，例如其中感兴趣的分子变性的样品。 如果与对照样品相比，测试样品中存在较少的标记，则测试样品可以包含聚集形式，折叠形式或交互形式的感兴趣分子，例如与另一种分子如蛋白质分子，DNA分子相互作用 或RNA分子。 本发明可以用于检测或监测诸如肌萎缩侧索硬化症（ALS）的疾病或病症。

公开(公告)号：WO2017180889A1

公开(公告)日：2017-10-19

申请号：PCT/US2017/027444

申请日：2017-04-13

Applicant: ARIZONA BOARD OF REGENTS ON BEHALF OF THE UNIVERSITY OF ARIZONA

Inventor： SCHWARTZ, Jacob ,  JEWETT, John, C. ,  MOINPOUR, Mahta ,  SHADMEHR, Mehrdad

IPC: C12P13/22 ,  G01N33/68 ,  G01N33/533

CPC classification number: G01N33/533 ,  C07K1/1136 ,  C07K1/13 ,  G01N33/52 ,  G01N33/57484 ,  G01N33/582 ,  G01N33/60 ,  G01N33/68 ,  G01N33/6803 ,  G01N33/6896

Abstract: Methods, systems, and compositions for detecting molecule aggregation, folding, or interactions featuring comparing the amount of labeling of a molecule of interest, such as a protein, in a test sample with an amount of labeling in a control, e.g., a sample wherein the molecule of interest is denatured. If less labeling is present in the test sample as compared to the control sample, the test sample may comprise the molecule of interest in aggregate form, folded form, or interactive form, e.g., interacting with another molecule such as a protein molecule, DNA molecule or RNA molecule.

Abstract translation: 用于检测分子聚集，折叠或相互作用的方法，系统和组合物，其特征在于将测试样品中感兴趣的分子如蛋白质的标记量与 对照，例如其中感兴趣的分子变性的样品。 如果与对照样品相比，测试样品中存在较少的标记，则测试样品可以包含聚集形式，折叠形式或交互形式的感兴趣分子，例如与另一种分子如蛋白质分子，DNA分子相互作用 或RNA分子。