公开(公告)号：WO2013012588A1

公开(公告)日：2013-01-24

申请号：PCT/US2012/045925

申请日：2012-07-09

Applicant: AVIDIEN TECHNOLOGIES ,  COTE, Richard

Inventor： COTE, Richard

IPC: B01L3/02

CPC classification number: B01L3/5025 ,  B01L3/0217 ,  B01L3/0275 ,  B01L3/5635 ,  B01L2200/021 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/026 ,  B01L2300/0829

Abstract: An adapter for connecting an array of pipette tips having through bores with conical upper ends to a multichannel air displacement pipettor having a plurality of ports with compliant internal sealing surfaces. The adapter comprises a planar base with an array of openings extending between its top and bottom surfaces. Sealing tubes project upwardly from the top surface, and tip mounting tubes project downwardly from the bottom surface, with pairs of sealing tubes and tip mounting tubes being arranged coaxially and in communication with respective ones of the openings in the base. The tip mounting tubes are externally dimensioned and configured for insertion into the conical upper ends of the pipette tips, and the sealing tubes are externally configured and dimensioned for insertion into the ports of the pipettor and into sealing interengagement with their compliant internal sealing surfaces.

Abstract translation: 用于将具有锥形上端的通孔的移液管尖端阵列连接到具有多个具有柔性内部密封表面的端口的多通道空气置换移液器的适配器。 适配器包括具有在其顶表面和底表面之间延伸的开口阵列的平面基座。 密封管从顶表面向上突出，并且尖端安装管从底表面向下突出，成对的密封管和尖端安装管同轴地布置并与底座中的相应开口连通。 尖端安装管的外部尺寸和构造用于插入移液管尖端的锥形上端，并且密封管在外部构造和尺寸设计成用于插入到移液器的端口中并且与它们的柔性内部密封表面密封地相互接合。

公开(公告)号：WO2020198347A2

公开(公告)日：2020-10-01

申请号：PCT/US2020/024696

申请日：2020-03-25

Applicant: AVIDIEN TECHNOLOGIES, INC.

Inventor： COTE, Richard

IPC: B01L3/02 ,  B01L9/00

Abstract: The technology relates in part to a segmented pipette tip adapter that includes a plurality of plate segments and a junction between adjacent plate segments. Each of the plate segments often includes a proximal surface, a distal surface, edges, one or more nozzles disposed on the proximal surface, and one or more tubular projections disposed on the distal surface. Each of the nozzles often includes a nozzle bore, each of the tubular projections often includes a tubular projection bore, each of the plate segments often includes a plate bore disposed at each of the nozzles, and each nozzle bore often is aligned with a tubular projection bore and a plate bore. Each junction often is between adjacent edges of a pair of adjacent plate segments.

公开(公告)号：WO2016081595A1

公开(公告)日：2016-05-26

申请号：PCT/US2015/061329

申请日：2015-11-18

Applicant: AVIDIEN TECHNOLOGIES

Inventor： COTE, Richard

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0227 ,  B01L2200/0689 ,  B01L2300/0829 ,  B01L2300/0861 ,  B01L2400/0478 ,  B01L2400/0666 ,  G01N35/1011 ,  G01N35/1065

Abstract: A pipetting system is disclosed that includes a pipette head including a multichannel air displacement system for aspirating and dispensing liquids, a pipetting system base that includes a linear guide system along which the pipette head may be moved vertically with respect to the pipetting system base, and counterbalance means for counterbalancing at least a portion of a weight of the pipette head.

Abstract translation: 本发明公开了一种移液器系统，它包括一个吸液头，它包括一个用于抽吸和分配液体的多通道空气排放系统，一个移液系统底座，包括一个直线导引系统，吸头可以相对于移液器系统底座垂直移动， 用于平衡移液管头的重量的至少一部分的平衡装置。

公开(公告)号：WO2009039039A1

公开(公告)日：2009-03-26

申请号：PCT/US2008/076195

申请日：2008-09-12

Applicant: VIAFLO CORPORATION ,  MATHUS, Gregory ,  COTE, Richard

Inventor： MATHUS, Gregory ,  COTE, Richard

IPC: B01L3/02

CPC classification number: B01L3/0227 ,  B01L3/0279 ,  B01L2200/087

Abstract: An ejection mechanism for a hand-held pipettor provides for varying degrees of mechanical advantage along the stroke of the ejector button. The ejection mechanism can be used for either hand-held single channel pipettors or hand-held multi-channel pipettors having manually actuated ejection mechanisms.

Abstract translation: 用于手持式移液器的排出机构提供沿着喷射器按钮的行程的不同程度的机械优点。 喷射机构可用于手持单通道移液器或具有手动驱动的排出机构的手持式多通道移液器。

公开(公告)号：WO2008051683A1

公开(公告)日：2008-05-02

申请号：PCT/US2007/080064

申请日：2007-10-01

Applicant: VIAFLO CORPORATION ,  MATHUS, Gregory ,  KELLY, Terrence ,  COTE, Richard

Inventor： MATHUS, Gregory ,  KELLY, Terrence ,  COTE, Richard

IPC: B01L3/02

CPC classification number: B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/087

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft (12) includes a locking section (30) located above a lower sealing section (32). The locking section (30) has outwardly extending locking lobes located above a stop member (34) and a lower sealing section (32) located below the stop member (34). When the mounting shaft (12) is fully- inserted into the collar (36) of the mating disposable pipette tip (14), the tip locks onto the mounting shaft (12). The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft (12). The dimensions of the collar, and in particular the distance between its circumferential shelf and the locking ring, are selected to match the dimensions of the mounting shaft (12) between the stop member (34) and the upper end of the locking lobes, thus locking the pipette tip (14) in a secure, reliable position and orientation while using ergonomic insertion and ejection forces. The locking lobes preferably include a ramp portion that gently flexes and distorts the pipette tip collar (36) out of round as the mounting shaft i(12) s inserted in the pipette tip (14), rather than stretching the tip collar (36). The circumferential shelf on the pipette tip (14) between the tip collar (36) and the barrel (38) isolates the sealing area at the upper end of the barrel (38) from distortion, thus facilitating reliable sealing engagement between the lower sealing section (32) of the mounting shaft (12) and the sealing ring in the upper end of the barrel (38) of the pipette tip (14).

Abstract translation: 一方面，本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴（12）包括位于下密封部分（32）上方的锁定部分（30）。 锁定部分（30）具有位于止动构件（34）上方的向外延伸的锁定凸角和位于止动构件（34）下方的下部密封部分（32）。 当安装轴（12）完全插入配合的一次性吸头（14）的套环（36）中时，尖端锁定到安装轴（12）上。 移液管尖端的孔包括将其上部套环与位于周向架下方的顶部密封区域分开的圆周架或肩部。 尖端衣领优选地包括位于安装轴（12）的上开口处或附近的锁定环。 轴环的尺寸，特别是其周向架和锁定环之间的距离被选择成与止动件（34）和锁定凸角的上端之间的安装轴（12）的尺寸相匹配，从而 在使用符合人体工程学的插入和弹出力的同时，将移液器吸头（14）锁定在安全可靠的位置和方向。 锁定凸耳优选地包括斜面部分，该斜坡部分随着安装轴i（12）插入到移液管尖端（14）中而使移液管尖端套环（36）轻轻地弯曲并变形，而不是拉伸尖端套环（36） 。 顶尖套环（36）和筒体（38）之间的移液器吸头（14）上的圆周架子将筒体（38）的上端处的密封区域与变形隔离，从而有助于下密封部分 （32）和所述吸头（14）的筒体（38）的上端中的密封环。

公开(公告)号：WO2009058952A1

公开(公告)日：2009-05-07

申请号：PCT/US2008/081716

申请日：2008-10-30

Applicant: VIAFLO CORPORATION ,  MATHUS, Gregory ,  KELLY, Terrence ,  COTE, Richard

Inventor： MATHUS, Gregory ,  KELLY, Terrence ,  COTE, Richard

IPC: B01L3/02

CPC classification number: B01L3/0217 ,  B01L3/0275 ,  B01L3/0279 ,  B01L2200/023 ,  B01L2200/025 ,  B01L2200/0689 ,  B01L2200/087 ,  B01L2300/027 ,  Y10T137/0318 ,  Y10T436/2575

Abstract: In one aspect, the invention relates to a pipette tip mounting shaft configuration and a disposable pipette tip having a matching configuration. The mounting shaft (112) includes a locking section (130) located above a lower sealing section (132). The locking section (130) has outwardly extending locking lobes (50) located above a stop member (34) and a lower sealing section (132) located below the stop member (34). In certain embodiments, the diameter of the mounting shaft below the stop member is reduced in order to lessen insertion and ejection forces, which is particularly helpful for hand-held multi-channel pipettors. In these embodiments, the lower sealing section contains either a frustoconical sealing section, or an annular groove (135) and a sealing ring (137), such as a f louroelastomeric 0-ring seal. When the mounting shaft is fully inserted into the collar of the mating disposable pipette tip (14), the tip (14) locks onto the mounting shaft (112). The bore of the pipette tip includes a circumferential shelf or shoulder separating its upper collar from the tip sealing area which is located below the circumferential shelf. The tip collar preferably includes a locking ring located at or near the upper opening for the mounting shaft.

Abstract translation: 一方面，本发明涉及移液器吸头安装轴构造和具有匹配构型的一次性吸头。 安装轴（112）包括位于下密封部分（132）上方的锁定部分（130）。 锁定部分（130）具有位于止动构件（34）上方的向外延伸的锁定凸角（50）和位于止动构件（34）下方的下部密封部分（132）。 在某些实施例中，降低止动件下方的安装轴的直径以减小插入和弹出力，这对手持式多通道移液器特别有帮助。 在这些实施例中，下密封部分包含截头圆锥形密封部分，或环形凹槽（135）和密封环（137），例如f型罗勒弹性O形密封件。 当安装轴完全插入配合的一次性吸头（14）的套环中时，尖端（14）锁定在安装轴（112）上。 移液管尖端的孔包括将其上部套环与位于周向架下方的顶部密封区域分开的圆周架或肩部。 尖端衣领优选地包括位于或靠近用于安装轴的上部开口的锁定环。

公开(公告)号：WO2011140079A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/034985

申请日：2011-05-03

Applicant: INTEGRA BIOSCIENCES CORP. (FORMERLY VIAFLO CORPORATION) ,  WARHURST, Julian ,  COTE, Richard

Inventor： WARHURST, Julian ,  COTE, Richard

IPC: B01L3/02 ,  G01N35/10 ,  G01N35/00 ,  B25J13/02

CPC classification number: B01L3/0234 ,  B01L3/0227 ,  B01L3/0237 ,  B01L2200/087 ,  B01L2300/027 ,  B01L2300/0829 ,  B01L2400/0478 ,  G01N35/1074

Abstract: A manually directed, electronic multi-channel pipettor uses servo controlled motors to drive a carriage and pipetting head in response to a user's manipulation of a control handle. The pipetting head include an array of tip fittings, e.g. 96. The system includes a check processor to avoid unintended motion in case of system faults or crashes. The system requires substantial force to attach the array of tips, and therefore includes controls that require both of the user's hands be occupied during the tip attachment process.

Abstract translation: 手动导向的电子多通道移液器使用伺服控制的电动机来响应用户对控制手柄的操纵来驱动支架和移液头。 移液头包括尖端配件的阵列，例如 96.系统包括一个检查处理器，以避免系统故障或崩溃时的意外运动。 该系统需要相当大的力来附接尖端阵列，因此包括需要在尖端附着过程期间使用者的双手被占用的控制。

公开(公告)号：WO2011140063A1

公开(公告)日：2011-11-10

申请号：PCT/US2011/034961

申请日：2011-05-03

Applicant: INTEGRA BIOSCIENCES CORP. (formerly VIAFLO CORPORATION) ,  WARHURST, Julian ,  NELSON, Gary ,  COTE, Richard

Inventor： WARHURST, Julian ,  NELSON, Gary ,  COTE, Richard

IPC: B01L3/02 ,  G01N35/10 ,  G01N35/00 ,  B25J13/02

CPC classification number: B01L3/0227 ,  B01L3/0234 ,  B01L3/0237 ,  B01L9/523 ,  B01L2200/087 ,  B01L2200/146 ,  B01L2300/027 ,  B01L2300/06 ,  B01L2300/0829 ,  B01L2400/0478

Abstract: A manually directed, multi-channel electronic pipetting system is designed to transfer liquids from a standard multi-well plate, deep-well plate or reservoir into another multi-well plate. The preferred pipetting head includes an array of 96-tip fittings. A deck with at least one but preferably two or more wellplate nesting receptacles holds one or more multi-well plates or reagent reservoirs for access by an array of disposable pipette tips mounted to the pipetting head. The electronic motion control system includes a control handle that is mounted to a load cell, the carriage for the pipetting head and is held in the palm of the user. In use, the user grasps the control handle and operates the system in a manner similar to one using a handheld electronic pipettor.

Abstract translation: 手动导向的多通道电子移液系统被设计成将液体从标准的多孔板，深井板或储存器转移到另一个多孔板中。 优选的移液头包括96针头配件的阵列。 具有至少一个但优选两个或更多个孔板嵌套容器的甲板容纳一个或多个多孔板或试剂储存器，用于通过安装到移液头的一次性吸头的阵列进入。 电子运动控制系统包括安装到称重传感器的控制手柄，用于移液头的托架并保持在使用者手掌中。 在使用中，用户抓住控制手柄并以类似于使用手持电子移液器的方式操作系统。

公开(公告)号：WO2009137235A2

公开(公告)日：2009-11-12

申请号：PCT/US2009/040446

申请日：2009-04-14

Applicant: VIAFLO CORPORATION ,  BUTZ, David, E. ,  MATHUS, Gregory ,  COTE, Richard ,  KALMAKIS, George, P.

Inventor： BUTZ, David, E. ,  MATHUS, Gregory ,  COTE, Richard ,  KALMAKIS, George, P.

IPC: B01L3/02

CPC classification number: B01L3/0237 ,  B01L3/0217 ,  B01L3/0227 ,  B01L2200/022

Abstract: A hand-held, multi-channel pipettor has an electronically controlled motor to reposition pipette tips for different center to center spacing. Each repositionable tip fitting assembly has a cam following pin that is driven by cam tracks in a motor driven roller drum. Stationary ports for the multiple aspiration cylinders are strategically placed to simplify management of flexible tubes leading to the repositionable pipette tip fitting assemblies. The pipettor has a user interface that can be operated conveniently by one hand to reposition pipette tips. It has a pipette tip ejection mechanism with a sinusoidal stripper bar.

Abstract translation: 手持式多通道移液器具有电子控制电机，用于重新定位不同中心间距的吸头。 每个可重新定位的尖端配件组件具有凸轮跟随销，该凸轮跟随销由马达驱动滚筒中的凸轮轨道驱动。 用于多个抽吸气瓶的固定端口有策略地放置，以简化导向可重新定位的移液管尖端配件组件的柔性管的管理。 移液器具有可以用一只手方便地操作以重新定位移液器吸头的用户界面。 它具有带有正弦剥离器条的移液管尖端喷射机构。

公开(公告)号：WO2008042508A1

公开(公告)日：2008-04-10

申请号：PCT/US2007/075960

申请日：2007-08-15

Applicant: UNIVERSITY OF SOUTHERN CALIFORNIA ,  LEE, Amy, S. ,  COTE, Richard

Inventor： LEE, Amy, S. ,  COTE, Richard

IPC: G01N33/574 ,  A61P35/00

CPC classification number: G01N33/57434 ,  G01N33/57415 ,  G01N2800/44 ,  G01N2800/52

Abstract: The present application provides methods for detecting, diagnosing, monitoring, predicting responsiveness to therapeutic agents and staging cancer. The present application provides methods and compositions useful for suppression of GRP78 expression or activity in cancer cells to overcome resistance of certain therapeutic agents. The present application also provides methods for predicting whether a subject with cancer is at risk for developing resistance to certain therapeutic agents.

Abstract translation: 本申请提供了用于检测，诊断，监测，预测对治疗剂的反应性和分期癌症的方法。 本申请提供了可用于抑制癌细胞中GRP78表达或活性以克服某些治疗剂抗性的方法和组合物。 本申请还提供了用于预测患有癌症的受试者是否面临发展对某些治疗剂的抗性的风险的方法。