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    ALTERATION AND MODULATION OF PROTEIN ACTIVITY BY VARYING POST-TRANSLATIONAL MODIFICATION
    2.
    发明申请
    ALTERATION AND MODULATION OF PROTEIN ACTIVITY BY VARYING POST-TRANSLATIONAL MODIFICATION 审中-公开
    通过改变后期修改来改变和调节蛋白质活性

    公开(公告)号：WO2010099394A9

    公开(公告)日：2011-10-13

    申请号：PCT/US2010025521

    申请日：2010-02-26

    Applicant: BATTELLE ENERGY ALLIANCE LLC

    Inventor： THOMPSON DAVID N ,  REED DAVID W ,  THOMPSON VICKI S ,  LACEY JEFFREY A ,  APEL WILLIAM A

    IPC: C07K14/195 ,  C12P21/02

    CPC classification number: C12P21/005 ,  C07K14/195 ,  C12N9/1048 ,  C12N9/2437 ,  C12N9/248

    Abstract: Embodiments of the invention include methods of altering the enzymatic activity or solubility of an extremophilic enzyme or post-translationally modifying a protein of interest via using isolated or partially purified glycosyltransferases and/or post-translational modification proteins, extracts of cells comprising glycosyltransferases and/or post-translational modification proteins, and/or in cells comprising one or more glycosyltransferases and/or post-translational modification proteins.

    Abstract translation: 本发明的实施方案包括通过使用分离或部分纯化的糖基转移酶和/或翻译后修饰蛋白来改变极端酶的酶活性或溶解度或翻译后修饰目的蛋白质的方法，包含糖基转移酶和/或 和/或包含一个或多个糖基转移酶和/或翻译后修饰蛋白的细胞。

    ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL
    5.
    发明申请
    ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL OR SOURCE OF A BIOLOGICAL MATERIAL 审中-公开
    用于鉴定生物材料的个体或来源的抗体概况，方法和设备

    公开(公告)号：WO2014151021A2

    公开(公告)日：2014-09-25

    申请号：PCT/US2014024779

    申请日：2014-03-12

    Applicant: BATTELLE ENERGY ALLIANCE LLC

    Inventor： APEL WILLIAM A ,  THOMPSON VICKI S ,  LACEY JEFFREY A ,  PARK SHAWNA

    IPC: G01N33/543

    CPC classification number: G01N33/6854

    Abstract: A sample of a biological material having individual-specific antibodies is contacted with an array of less than about 200 proteins on a support to bind some of the individual-specific antibodies to the proteins of the array to form immune complexes. A detection agent with an interacting protein for conjugation to a marker is applied to the array to detect the immune complexes and obtain an antibody profile, which is compared to a known antibody profile obtained from an individual. The array may further include control spots including human IgG to form control complexes and volume assessment spots including volume determination proteins to form volume complexes. Intensity of the control complexes may be detected to determine if results of the identifying are complete. Intensity of the volume complexes may be detected to determine if a volume of the sample is sufficient for an accurate result.

    Abstract translation: 使具有个体特异性抗体的生物材料样品与载体上小于约200个蛋白质的阵列接触，以将一些个体特异性抗体与阵列的蛋白质结合以形成免疫复合物。 将具有用于与标记物缀合的相互作用蛋白质的检测剂应用于阵列以检测免疫复合物并获得抗体谱，其与从个体获得的已知抗体谱相比较。 阵列可以进一步包括对照斑点，包括人IgG以形成对照复合物和包括体积测定蛋白质在内的体积评估点以形成体积复合物。 可以检测对照复合物的强度以确定鉴定的结果是否完整。 可以检测体积复合物的强度以确定样品的体积是否足以获得准确的结果。

    IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL
    7.
    发明申请
    IDENTIFICATION OF DISCRIMINANT PROTEINS THROUGH ANTIBODY PROFILING, METHODS AND APPARATUS FOR IDENTIFYING AN INDIVIDUAL 审中-公开
    通过抗体分类识别染色体蛋白，识别个体的方法和装置

    公开(公告)号：WO2011037827A3

    公开(公告)日：2011-07-21

    申请号：PCT/US2010049227

    申请日：2010-09-17

    Applicant: BATTELLE ENERGY ALLIANCE LLC

    Inventor： APEL WILLIAM A ,  THOMPSON VICKI S ,  LACEY JEFFREY A ,  GENTILLON CYNTHIA A

    IPC: G01N33/53

    CPC classification number: G01N33/6845

    Abstract: A method for determining a plurality of proteins for discriminating and positively identifying an individual based from a biological sample. The method may include profiling a biological sample from a plurality of individuals against a protein array including a plurality of proteins. The protein array may include proteins attached to a support in a preselected pattern such that locations of the proteins are known. The biological sample may be contacted with the protein array such that a portion of antibodies in the biological sample reacts with and binds to the proteins forming immune complexes. A statistical analysis method, such as discriminant analysis, may be performed to determine discriminating proteins for distinguishing individuals. Proteins of interest may be used to form a protein array. Such a protein array may be used, for example, to compare a forensic sample from an unknown source with a sample from a known source.

    Abstract translation: 一种用于确定多个蛋白质的方法，用于基于生物样品鉴别和阳性鉴定个体。 该方法可以包括从多个个体对包含多个蛋白质的蛋白质阵列分析生物样品。 蛋白质阵列可以包括以预选图案连接到载体的蛋白质，使得蛋白质的位置是已知的。 生物样品可以与蛋白质阵列接触，使得生物样品中的一部分抗体与形成免疫复合物的蛋白质反应并结合。 可以进行诸如判别分析的统计分析方法来确定用于区分个体的鉴别蛋白质。 可以使用感兴趣的蛋白质来形成蛋白质阵列。 这样的蛋白质阵列可以用于例如将来自未知来源的法医样品与来自已知来源的样品进行比较。

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