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    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS
    1.
    发明申请
    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS 审中-公开
    微生物菌株的应用及其使用方法来控制植物病虫害

    公开(公告)号：WO2014059275A2

    公开(公告)日：2014-04-17

    申请号：PCT/US2013/064537

    申请日：2013-10-11

    申请人： BAYER CROPSCIENCE LP, A DELAWARE LIMITED PARTNERSHIP

    发明人： CAMPBELL, Brian ,  CURTIS, Damian ,  GUAN, Shaohua ,  GUILHABERT-GOYA, Magalie ,  JOO, Daniel, M. ,  LU, Tara ,  MARGOLIS, Jonathan, S. ,  ROYALTY, Reed, Nathan ,  SALAZAR, Gerardo, Bueno ,  SESIN, David ,  SMITH, Frisby, Davis ,  TAYLOR, Colleen ,  ZHU, Hong

    IPC分类号： C12P19/28 ,  C07H19/06

    CPC分类号： A01N63/02 ,  A01N43/54 ,  C12P19/28 ,  C12P19/385

    摘要： The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 1 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions, wherein the culture medium contains an amino acid at a concentration effective to achieve a gougerotin concentration of at least 1 g/L. The present disclosure also relates to the molecular cloning of a gougerotin biosynthetic gene cluster from Streptomyces microflavus, and identification of individual genes in the gene cluster as well as the proteins encoded thereby. A gougerotin gene cluster comprising 13 open reading frames (ORFs) is located within a genetic locus of Streptomyces microflavus.

    摘要翻译： 本发明涉及新霉菌Streptomyces microflavus及其用于控制​​植物疾病或害虫的方法。 本发明还涉及通过培养产生Gougerotin的链霉菌菌株而获得的发酵液，其中发酵液含有至少约1g / L gougerotin。 本发明还涉及一种生产发酵木瓜霉菌菌株发酵液的方法，其中发酵液含有至少约1g / L gougerotin，该方法包括在含有可消化碳源的培养基中培养链霉菌属菌株， 在需氧条件下的可消化氮源，其中培养基含有浓度达到至少1g / L的gougerotin浓度的氨基酸。 本公开还涉及从Streptomyces microflavus分子克隆gougerotin生物合成基因簇，以及鉴定基因簇中的各个基因以及由此编码的蛋白质。 包含13个开放阅读框（ORF）的gougerotin基因簇位于Streptomyces microflavus的遗传基因座内。

    COMPOSITIONS COMPRISING A STREPTOMYCES-BASED BIOLOGICAL CONTROL AGENT AND ANOTHER BIOLOGICAL CONTROL AGENT
    2.
    发明申请
    COMPOSITIONS COMPRISING A STREPTOMYCES-BASED BIOLOGICAL CONTROL AGENT AND ANOTHER BIOLOGICAL CONTROL AGENT 审中-公开
    包含基于分子生物学的生物控制剂和其他生物控制剂的组合物

    公开(公告)号：WO2014124361A1

    公开(公告)日：2014-08-14

    申请号：PCT/US2014/015561

    申请日：2014-02-10

    申请人： BAYER CROPSCIENCE LP

    发明人： ANDERSCH, Wolfram ,  CURTIS, Damian ,  GUAN, Shaohua ,  GUILHABERT-GOYA, Magalie ,  ROYALTY, Reed, Nathan ,  SMITH, Frisby, Davis ,  SPRINGER, Bernd ,  THIELERT, Wolfgang ,  ZHU, Hong

    IPC分类号： A01N43/54 ,  A01N63/02 ,  A01N63/04 ,  A01P3/00

    CPC分类号： A01N43/54 ,  A01N63/00 ,  A01N63/02 ,  A01N63/04 ,  C12R1/07 ,  C12R1/125 ,  C12R1/465 ,  Y02A50/356

    摘要： The present invention relates to a composition comprising a) Streptomyces microflavus strain NRRL B-50550 and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and/or a mutant thereof having all the identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens and b) at least one further biological control agent selected from specific microorganisms and/or a mutant of it having all identifying characteristics of the respective strain, and/or at least one metabolite produced by the respective strain that exhibits activity against insects, mites, nematodes and/or phytopathogens in a synergistically effective amount. Furthermore, the present invention relates to the use of this composition as well as a method for reducing overall damage of plants and plant parts.

    摘要翻译： 本发明涉及一种组合物，其包含a）具有所述各菌株的所有鉴定特征的微生物链霉菌微链菌菌株NRRL B-50550和/或其突变体，和/或由相应菌株产生的至少一种对昆虫具有活性的代谢物 具有所有鉴定特征的各种菌株的螨虫，线虫和/或植物病原体和/或其突变体和/或由相应菌株产生的至少一种代表物，其对昆虫，螨虫，线虫和/或植物病原体具有活性， b）至少一种选自特定微生物和/或具有各种菌株的所有鉴定特征的特异性微生物和/或其突变体的至少一种生物防治剂，和/或由各种菌株产生的至少一种代表物，其对昆虫，螨虫，线虫具有活性 和/或协同有效量的植物病原体。 此外，本发明涉及该组合物的用途以及减少植物和植物部分总体损伤的方法。

    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS
    5.
    发明申请
    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE TO CONTROL PLANT DISEASES AND PESTS 审中-公开
    微生物菌株的应用及其使用方法来控制植物病虫害

    公开(公告)号：WO2015161111A1

    公开(公告)日：2015-10-22

    申请号：PCT/US2015/026229

    申请日：2015-04-16

    申请人： BAYER CROPSCIENCE LP

    发明人： CURTIS, Damian ,  GUAN, Shaohua ,  GUILHABERT-GOYA, Magalie ,  MARGOLIS, Jonathan, S. ,  ROYALTY, Reed, Nathan ,  SMITH, Frisby, Davis ,  TAYLOR, Colleen ,  ZHU, Hong

    IPC分类号： A01N43/54 ,  A01N63/02

    CPC分类号： C12P19/40 ,  A01N43/54 ,  A01N63/02

    摘要： The present invention relates to novel strains of Streptomyces microflavus and methods of their use for controlling diseases or pests of a plant. The invention also relates to a fermentation broth obtained by cultivating a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 2 g/L gougerotin. The invention also relates to a method of producing a fermentation broth of a gougerotin producing Streptomyces strain, wherein the fermentation broth contains at least about 2 g/L gougerotin, the method comprising cultivating the Streptomyces strain in a culture medium containing a digestible carbon source and a digestible nitrogen source under aerobic conditions.

    摘要翻译： 本发明涉及新霉菌Streptomyces microflavus及其用于控制​​植物疾病或害虫的方法。 本发明还涉及通过培养产生Gougerotin的链霉菌属菌株获得的发酵液，其中发酵液含有至少约2g / L gougerotin。 本发明还涉及一种生产发酵链霉菌菌株发酵液的方法，其中发酵液含有至少约2g / L gougerotin，该方法包括在含有可消化碳源的培养基中培养链霉菌属菌株， 在有氧条件下可消化氮源。

    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE FOR THE TREATMENT AND PREVENTION OF CITRUS GREENING DISEASE
    6.
    发明申请
    STREPTOMYCES MICROFLAVUS STRAINS AND METHODS OF THEIR USE FOR THE TREATMENT AND PREVENTION OF CITRUS GREENING DISEASE 审中-公开
    应用微生物菌株及其用于治疗和预防绿豆病的方法

    公开(公告)号：WO2015048627A1

    公开(公告)日：2015-04-02

    申请号：PCT/US2014/058017

    申请日：2014-09-29

    申请人： BAYER CROPSCIENCE LP, A DELAWARE LIMITED PARTNERSHIP

    发明人： ROYALTY, Reed, Nathan ,  SMITH, Frisby, Davis

    IPC分类号： A01N63/00 ,  A01P1/00

    CPC分类号： A01N63/00

    摘要： The present invention relates to the use of strains of Streptomyces microflavus for preventing and treating bacterial diseases such as citrus greening in a plant. The invention also relates to a method of preventing or treating a bacterial disease in a plant comprising applying a fermentation product comprising a gougerotin-producing Streptomyces strain to the plant, to a part of the plant and/or to a locus of the plant.

    摘要翻译： 本发明涉及用于预防和治疗细菌性疾病如植物中柑橘绿化的Streptomyces microflavus菌株的用途。 本发明还涉及一种在植物中预防或治疗细菌性疾病的方法，包括将包含产生gougerotin的链霉菌属菌株的发酵产物施用于植物的一部分和/或植物的部位。