公开(公告)号：WO2016196962A1

公开(公告)日：2016-12-08

申请号：PCT/US2016/035765

申请日：2016-06-03

Applicant: BIOAMBER INC.

Inventor： LAU, Man, Kit ,  HASS, Cathy, Staloch ,  AHMED, Hayat, Nuru ,  BAKER, Ralph, Thomas ,  MILLIS, James, R. ,  THAPA, Indira

IPC: C07K14/38 ,  C07K14/395 ,  C07K14/415 ,  C07K14/435 ,  C12N1/32

CPC classification number: C12N9/1096 ,  C07C51/377 ,  C07C51/38 ,  C07C59/147 ,  C07C59/185 ,  C07K14/38 ,  C07K14/395 ,  C12N1/32 ,  C12N9/1025 ,  C12N9/16 ,  C12N9/88 ,  C12N15/52 ,  C12P7/42 ,  C12P7/46 ,  C12P7/58 ,  C12P7/62 ,  C12Y203/03014 ,  C12Y206/01045 ,  C12Y301/0306 ,  C12Y402/01003

Abstract: The description relates to, inter alia, recombinant microorganisms, engineered metabolic pathways, chemical catalysts, and products produced through the use of the described methods and materials. The products produced include functionalized alpha substituted C4 dicarboxylic acids, as well as functionalized malonyl-CoA, malonic semialdehyde, and acrylic acids, and their salts, esters and lactones.

Abstract translation: 该描述尤其涉及重组微生物，工程化代谢途径，化学催化剂和通过使用所述方法和材料生产的产品。 产生的产物包括官能化的α取代的C4二羧酸，以及官能化的丙二酰辅酶A，丙二酸和丙烯酸及其盐，酯和内酯。