公开(公告)号：WO2017160793A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022241

申请日：2017-03-14

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： MORRISON, Clifford S. ,  ARMIGER, William B. ,  DODDS, David R. ,  KOFFAS, Mattheos

IPC: C12P19/36 ,  A61K31/7084 ,  C07H19/207 ,  C12P19/26 ,  C12P19/32 ,  H01M8/06

Abstract: Provided herein a re composition and process for using an electrochemica l device for the reduction of the oxidized state of phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide to the reduced state in which unwanted products of the electrochemical reduction are recovered as the oxidized state of the phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide and returned to the electrochemical device for reduction.

Abstract translation: 本文提供了使用电化学装置将磷酸化或非磷酸化烟酰胺腺嘌呤二核苷酸的氧化态还原成还原态的再组合物和方法，其中电化学还原的不需要的产物是 作为磷酸化或非磷酸化烟酰胺腺嘌呤二核苷酸的氧化态被回收并返回到电化学装置进行还原。

公开(公告)号：WO2016137976A1

公开(公告)日：2016-09-01

申请号：PCT/US2016/019102

申请日：2016-02-23

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： DODDS, David R. ,  ARMIGER, William B. ,  KOFFAS, Mattheos

IPC: C12P1/00 ,  C12P7/16

CPC classification number: C12P7/16 ,  C12M45/07 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01027 ,  C12Y101/01157 ,  C12Y102/0101 ,  C12Y102/01046 ,  C12Y102/01057 ,  C12Y102/04001 ,  C12Y103/01006 ,  C12Y103/01038 ,  C12Y203/01008 ,  C12Y203/01009 ,  C12Y203/01054 ,  C12Y401/02043 ,  C12Y503/01027 ,  C25B3/04 ,  C25B9/08 ,  C25B15/02 ,  C25B15/08 ,  Y02E50/10

Abstract: A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency.

Abstract translation: 公开了一种用于递送还原当量至细胞的电化学装置和能够利用电化学提供的还原当量的细胞内工程化代谢途径的组合。 这种组合允许通过发酵生产商品化学品以提高碳效率。

公开(公告)号：WO2016141247A1

公开(公告)日：2016-09-09

申请号：PCT/US2016/020782

申请日：2016-03-03

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： ARMIGER, William B. ,  DODDS, David R.

IPC: B01D11/02

CPC classification number: C07G1/00 ,  B01D11/02 ,  B01D11/0288 ,  C08H6/00 ,  C08L97/005

Abstract: Provided herein is process and system for the production of high-quality lignin by treating the post-fermentation solids. In one aspect, the present disclosure relates to a novel process comprising: providing a solid material remaining at the end of a fermentation process, wherein the fermentation process utilizes a lignocellulosic biomass feedstock; extracting lignin from the solid material into a liquid phase; and recovering lignin from liquid phase. In some embodiments, the fermentation process produces one or more of ethanol, n-butanol, iso-butanol, lactic acid, polyhydroxyalkanoates, succinic acid, 1,3- propanediol and 1,4-butanediol. In one embodiment's, the fermentation process produces ethanol.

Abstract translation: 本文提供了通过处理后发酵固体来生产高质量木质素的方法和系统。 一方面，本公开涉及一种新方法，其包括：提供在发酵过程结束时残留的固体材料，其中所述发酵方法利用木质纤维素生物质原料; 将木质素从固体材料中提取成液相; 并从液相中回收木质素。 在一些实施方案中，发酵过程产生乙醇，正丁醇，异丁醇，乳酸，聚羟基链烷酸酯，琥珀酸，1,3-丙二醇和1,4-丁二醇中的一种或多种。 在一个实施方案中，发酵过程产生乙醇。

公开(公告)号：WO2016070168A1

公开(公告)日：2016-05-06

申请号：PCT/US2015/058560

申请日：2015-11-02

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： ARMIGER, William B. ,  DODDS, David R.

IPC: C25B9/08

CPC classification number: C25B9/08 ,  C12P1/00 ,  C12P3/00 ,  C12Y101/01 ,  C12Y101/01001 ,  C25B3/04

Abstract: A device and process for using the device are provided for the production of commodity, specialty, performance or fine chemicals by redox enzyme systems which require the addition of reducing equivalents. The device allows operating conditions to be conveniently altered to achieve maximal electrochemical efficiencies for a given enzymatically mediated redox reaction or series of reactions.

Abstract translation: 提供了一种用于使用该装置的装置和方法，用于通过需要添加还原当量的氧化还原酶系统来生产商品，专业，性能或精细化学品。 该装置允许方便地改变操作条件以实现给定的酶促介导的氧化还原反应或一系列反应的最大电化学效率。