公开(公告)号：WO2016137976A1

公开(公告)日：2016-09-01

申请号：PCT/US2016/019102

申请日：2016-02-23

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： DODDS, David R. ,  ARMIGER, William B. ,  KOFFAS, Mattheos

IPC: C12P1/00 ,  C12P7/16

CPC classification number: C12P7/16 ,  C12M45/07 ,  C12N9/0006 ,  C12N9/0008 ,  C12N9/001 ,  C12N9/1029 ,  C12N9/88 ,  C12N9/90 ,  C12N15/52 ,  C12Y101/01001 ,  C12Y101/01027 ,  C12Y101/01157 ,  C12Y102/0101 ,  C12Y102/01046 ,  C12Y102/01057 ,  C12Y102/04001 ,  C12Y103/01006 ,  C12Y103/01038 ,  C12Y203/01008 ,  C12Y203/01009 ,  C12Y203/01054 ,  C12Y401/02043 ,  C12Y503/01027 ,  C25B3/04 ,  C25B9/08 ,  C25B15/02 ,  C25B15/08 ,  Y02E50/10

Abstract: A combination of an electrochemical device for delivering reducing equivalents to a cell, and engineered metabolic pathways within the cell capable of utilizing the electrochemically provided reducing equivalents is disclosed. Such a combination allows the production of commodity chemicals by fermentation to proceed with increased carbon efficiency.

Abstract translation: 公开了一种用于递送还原当量至细胞的电化学装置和能够利用电化学提供的还原当量的细胞内工程化代谢途径的组合。 这种组合允许通过发酵生产商品化学品以提高碳效率。

公开(公告)号：WO2017160793A1

公开(公告)日：2017-09-21

申请号：PCT/US2017/022241

申请日：2017-03-14

Applicant: BIOCHEMINSIGHTS, INC.

Inventor： MORRISON, Clifford S. ,  ARMIGER, William B. ,  DODDS, David R. ,  KOFFAS, Mattheos

IPC: C12P19/36 ,  A61K31/7084 ,  C07H19/207 ,  C12P19/26 ,  C12P19/32 ,  H01M8/06

Abstract: Provided herein a re composition and process for using an electrochemica l device for the reduction of the oxidized state of phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide to the reduced state in which unwanted products of the electrochemical reduction are recovered as the oxidized state of the phosphorylated or non-phosphorylated nicotinamide adenine dinucleotide and returned to the electrochemical device for reduction.

Abstract translation: 本文提供了使用电化学装置将磷酸化或非磷酸化烟酰胺腺嘌呤二核苷酸的氧化态还原成还原态的再组合物和方法，其中电化学还原的不需要的产物是 作为磷酸化或非磷酸化烟酰胺腺嘌呤二核苷酸的氧化态被回收并返回到电化学装置进行还原。