公开(公告)号：WO2016176425A1

公开(公告)日：2016-11-03

申请号：PCT/US2016/029735

申请日：2016-04-28

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION ,  DOAN, Que T. ,  HERSHEY, Bradley Lawrence ,  ZHU, Changfang

Inventor： DOAN, Que T. ,  HERSHEY, Bradley Lawrence ,  ZHU, Changfang

IPC: A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36135 ,  A61N1/3615 ,  A61N1/37241 ,  A61N1/37247

Abstract: An example a system includes a neuromodulation generator that may be configured to use electrodes to generate a first modulation field over a test region of neural tissue along the electrodes to prime the neural tissue throughout the test region and a second modulation field to test targeted locations within the test region for therapeutic effectiveness. A memory may be configured to store a first modulation field parameter for generating the first modulation field and a second modulation field parameter set for generating the second modulation field to modulate a targeted location within the test region. The second modulation field parameter set is programmable for modulating other targeted locations. The controller may be configured to control the neuromodulation generator to use the first modulation field parameter set to deliver the first modulation field and to use the second modulation field parameter set to deliver the second modulation field.

Abstract translation: 示例性系统包括神经调节发生器，其可以被配置为使用电极在沿着电极的神经组织的测试区域上产生第一调制场，以在整个测试区域内引导神经组织，以及第二调制场来测试目标位置 测试区域的治疗效果。 存储器可以被配置为存储用于生成第一调制域的第一调制场参数和用于生成第二调制域的第二调制场参数集，以调制测试区域内的目标位置。 第二调制场参数集是可编程的，用于调制其他目标位置。 控制器可以被配置为控制神经调节发生器以使用第一调制场参数集来传递第一调制场并使用第二调制场参数集来传递第二调制域。

公开(公告)号：WO2016048968A2

公开(公告)日：2016-03-31

申请号：PCT/US2015/051367

申请日：2015-09-22

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： MOFFITT, Michael A. ,  HERSHEY, Bradley Lawrence ,  ZHU, Changfang ,  PARRAMON, Jordi ,  KOTHANDARAMAN, Sridhar

IPC: A61N1/36

CPC classification number: A61N1/36185 ,  A61N1/0551 ,  A61N1/36021 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/3616 ,  A61N1/36164 ,  A61N1/37241 ,  A61N1/37247

Abstract: An example of a system may include an arrangement of electrodes configured to be operationally positioned for use in modulating targeted neural tissue, a neural modulator, a communication module, and a controller. The neural modulator may be configured to use at least some electrodes within the arrangement of electrodes to generate a modulation field. The communication module may be configured to receive user-provided selections. The controller may be configured to use the communication module to receive a user-provided selection of a desired electrode list where the electrode list identifies electrodes within the arrangement of electrodes that are available for use in modulating the targeted neural tissue, control the neural stimulation modulator to generate the modulation field, and use the electrodes identified in the electrode list to modulate the targeted neural tissue.

Abstract translation: 系统的示例可以包括被配置为在操作上定位以用于调制目标神经组织的电极的排列，神经调节器，通信模块和控制器。 神经调制器可以被配置成使用电极布置内的至少一些电极来生成调制场。 通信模块可以被配置为接收用户提供的选择。 控制器可以被配置为使用通信模块来接收用户提供的期望电极列表的选择，其中电极列表标识可用于调制目标神经组织的电极排列内的电极，控制神经刺激调节器 生成调制场，并使用电极列表中标识的电极来调制目标神经组织。

公开(公告)号：WO2016048965A1

公开(公告)日：2016-03-31

申请号：PCT/US2015/051360

申请日：2015-09-22

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： MOFFITT, Michael A. ,  ZHU, Changfang

IPC: A61N1/36 ,  A61N1/05

CPC classification number: A61N1/36189 ,  A61N1/0551 ,  A61N1/36071

Abstract: An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating neural tissue where the neural tissue including dorsal horn tissue or nerve root tissue, a neural modulation generator, and a controller. The neural modulation generator may be configured to use at least some electrodes to generate a modulation field. The neural modulation generator maybe configured to use a programmed modulation parameter set to promote uniformity of the modulation field in the dorsal horn tissue. The controller may be configured to control the neural modulation generator to generate the modulation field in pulse trains of at least two pulses.

Abstract translation: 系统的实例可以包括至少一个引线上的电极，其被配置为可操作地定位以用于调节包括​​背角组织或神经根组织的神经组织，神经调制发生器和控制器的神经组织。 神经调制发生器可以被配置为使用至少一些电极来产生调制场。 神经调制发生器可以被配置为使用编程调制参数集来促进背角组织中的调制场的均匀性。 控制器可以被配置为控制神经调制发生器以产生至少两个脉冲的脉冲串中的调制场。

公开(公告)号：WO2016048951A1

公开(公告)日：2016-03-31

申请号：PCT/US2015/051339

申请日：2015-09-22

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： MOFFITT, Michael A. ,  ZHU, Changfang

IPC: A61N1/36 ,  A61N1/372

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/3605 ,  A61N1/36128 ,  A61N1/36153 ,  A61N1/36164 ,  A61N1/37247

Abstract: An example of a system may include electrodes on at least one lead configured to be operationally positioned for use in modulating a volume of neural tissue, where the neural tissue has an activation function. The system may further include a neural modulation generator configured to deliver energy using at least some electrodes to generate a modulation field within the volume of neural tissue. The neural modulation generator may be configured to use a programmed modulation parameter set to generate the modulation field. The programmed modulation parameter set having values selected to control energy delivery using the at least some electrodes to achieve an objective function specific to the activation function of the volume of neural tissue to promote uniformity of a response to the modulation field in the volume of neural tissue along a span of the at least one lead.

Abstract translation: 系统的示例可以包括至少一个引线上的电极，其被配置为可操作地定位以用于调制神经组织的体积，其中神经组织具有激活功能。 该系统还可以包括被配置为使用至少一些电极传递能量以在神经组织的体积内产生调制场的神经调制发生器。 神经调制发生器可以被配置为使用编程调制参数集来生成调制字段。 编程调制参数集具有被选择用于使用至少一些电极来控制能量传递的值，以实现特定于神经组织的体积的激活功能的目标函数，以促进对神经组织的体积中的调制场的响应的均匀性 沿着至少一个引线的跨度。

公开(公告)号：WO2016048756A1

公开(公告)日：2016-03-31

申请号：PCT/US2015/050447

申请日：2015-09-16

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： HERSHEY, Bradley L. ,  ZHU, Changfang

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/36189 ,  A61N1/0551 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36139

Abstract: An example of a system for applying neuromodulation to a patient includes a modulation output circuit and a modulation control circuit. The modulation output circuit may be configured to deliver dorsal horn stimulation. The modulation control circuit may be configured to control the delivery of the dorsal horn stimulation by executing a neuromodulation algorithm using modulation parameters. The modulation control circuit may include a response input and a parameter calibrator. The response input may be configured to receive response information indicative of one or more responses to the stimulation of the dorsal horn. The parameter calibrator may be configured to adjust one or more of the modulation parameters using the response information.

Abstract translation: 用于向患者施加神经调节的系统的示例包括调制输出电路和调制控制电路。 调制输出电路可以被配置为提供背角刺激。 调制控制电路可以被配置为通过使用调制参数执行神经调制算法来控制背角刺激的传递。 调制控制电路可以包括响应输入和参数校准器。 响应输入可以被配置为接收指示对刺激背角的一个或多个响应的响应信息。 参数校准器可以被配置为使用响应信息来调整一个或多个调制参数。

公开(公告)号：WO2017210382A1

公开(公告)日：2017-12-07

申请号：PCT/US2017/035365

申请日：2017-06-01

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： DOAN, Que T. ,  HERSHEY, Bradley Lawrence ,  ZHU, Changfang

IPC: A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/36021 ,  A61N1/36062 ,  A61N1/36125 ,  A61N1/36164 ,  A61N1/36178

Abstract: A neuromodulation system executes a set of startup operations. In response to completion of the startup operations, a priming field is automatically initiated. The priming field is to produce a priming effect in priming-targeted neural tissue, with the priming effect causing a change in sensitization to a therapeutic neuromodulation field of the priming-targeted neural tissue. The system also generates the therapeutic neuromodulation field to produce a therapeutic effect in therapy-targeted neural tissue.

Abstract translation:

神经调节系统执行一组启动操作。 响应完成启动操作，启动字段自动启动。 启动区域在引发靶向神经组织中产生启动效应，启动效应引起启动靶向神经组织的治疗性神经调节场的敏化变化。 该系统还产生治疗性神经调节场，以在治疗靶向的神经组织中产生治疗效果。

公开(公告)号：WO2017035140A1

公开(公告)日：2017-03-02

申请号：PCT/US2016/048195

申请日：2016-08-23

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： MOFFITT, Michael A. ,  BRILL, Natalie A. ,  GU, Jianwen ,  HINCAPIE ORDONEZ, Juan Gabriel ,  ZHU, Changfang ,  BOKIL, Hemant ,  CARCIERI, Stephen

IPC: A61N1/36 ,  G06F19/00

CPC classification number: A61N1/025 ,  A61N1/36003 ,  A61N1/36007 ,  A61N1/3605 ,  A61N1/36071 ,  A61N1/36132 ,  A61N1/36135 ,  A61N1/36146 ,  A61N1/37247 ,  G06F19/00 ,  G16H20/30 ,  G16H50/20 ,  G16H50/70

Abstract: A system includes a processor and a memory device comprising instructions, which when executed by the processor, cause the processor to: access a patient metric of a subject; use the patient metric as an input to a machine learning algorithm, the machine learning algorithm to search a plurality of neuromodulation parameter sets and to identify a candidate neuromodulation parameter set of the plurality of neuromodulation parameter sets, the candidate neuromodulation parameter set designed to produce a non-regular waveform that varies over a time domain and a space domain; and program a neuromodulator using the candidate neuromodulation parameter set to stimulate the subject.

Abstract translation: 一种系统包括处理器和包括指令的存储器设备，所述指令当由处理器执行时使得处理器：访问对象的患者度量; 使用所述患者度量作为机器学习算法的输入，所述机器学习算法搜索多个神经调节参数集并且识别所述多​​个神经调节参数集合的候选神经调节参数集合，所述候选神经调节参数集被设计为产生 在时域和空间域上变化的非规则波形; 并使用候选神经调节参数设置神经调节器来刺激受试者。

公开(公告)号：WO2016191055A1

公开(公告)日：2016-12-01

申请号：PCT/US2016/030686

申请日：2016-05-04

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： ZHU, Changfang

IPC: A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/36189 ,  A61N1/37247

Abstract: An example of a system may include an electrode arrangement and a neuromodulation device configured to use electrodes in the electrode arrangement to generate a neuromodulation field. The neuromodulation device may include a neuromodulation generator, a neuromodulation control circuit and a storage. The storage may include a stochastically-modulated neuromodulation parameter set and the stochastically-modulated neuromodulation parameter set may include at least one stochastically-modulated parameter. The controller may be configured to control the neuromodulation generator using the stochastically-modulation parameter set to generate the neuromodulation field.

Abstract translation: 系统的示例可以包括电极装置和被配置为在电极装置中使用电极以产生神经调节区域的神经调节装置。 神经调节装置可以包括神经调节发生器，神经调节控制电路和存储器。 存储器可以包括随机调制神经调节参数集，并且随机调制神经调节参数集可以包括至少一个随机调制参数。 控制器可以被配置为使用随机调制参数集来控制神经调节发生器以产生神经调节场。

公开(公告)号：WO2016148778A1

公开(公告)日：2016-09-22

申请号：PCT/US2016/015308

申请日：2016-01-28

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： ZHU, Changfang ,  KOTHANDARAMAN, Sridhar ,  MARNFELDT, Goran, N. ,  LI, Yue

IPC: A61N1/372

CPC classification number: G06F3/0484 ,  A61N1/37211 ,  A61N1/37229 ,  A61N1/37247 ,  A61N1/3727 ,  G02B27/0172 ,  G02B27/0176 ,  G02B2027/0141 ,  G06F3/017 ,  G06F3/167 ,  G06F13/4282 ,  H04W4/80

Abstract: An Optical Head-Mounted Display (OHMD) for use as external controller for an Implantable Medical Device (IMD) is disclosed which includes an IMD communication accessory with a USB connector coupleable to a USB port on the OHMD. The accessory includes a housing with a communication antenna and telemetry transceiver circuitry to allow for direct communications with the IMD. The housing includes a battery for powering the transceiver circuitry and antenna. A cable may be coupled to the housing to allow the housing to be located proximate to patient's IMD when the communication means used in the IMD is relatively short range (e.g., magnetic induction). The housing may be cableless and comprise a dongle coupleable to a port on the OHMD if the communication means provided in the housing and used in the IMD are longer range (e.g., MICS).

Abstract translation: 公开了一种用作可植入医疗设备（IMD）的外部控制器的光头安装显示器（OHMD），其包括具有可连接到OHMD上的USB端口的USB连接器的IMD通信附件。 附件包括具有通信天线和遥测收发器电路的壳体，以允许与IMD的直接通信。 壳体包括用于为收发器电路和天线供电的电池。 当IMD中使用的通信装置是相对较短的范围（例如磁感应）时，电缆可以联接到壳体以允许外壳位于患者的IMD附近。 如果壳体中设置的并且在IMD中使用的通信装置较长的范围（例如，MICS），则壳体可以是无电缆的并且包括可耦合到OHMD上的端口的加密狗。

公开(公告)号：WO2016014624A1

公开(公告)日：2016-01-28

申请号：PCT/US2015/041469

申请日：2015-07-22

Applicant: BOSTON SCIENTIFIC NEUROMODULATION CORPORATION

Inventor： MOFFITT, Michael A. ,  HERSHEY, Bradley L. ,  ZHU, Changfang

IPC: A61N1/05 ,  A61N1/36

CPC classification number: A61N1/36071 ,  A61N1/0551 ,  A61N1/36132 ,  A61N1/36182 ,  A61N1/36192

Abstract: A method of providing therapy to a patient having a medical condition comprises delivering electrical stimulation energy to the spinal cord of the patient in accordance with a stimulation program that preferentially stimulates dorsal horn neuronal elements over dorsal column neuronal elements in the spinal cord. The delivered electrical stimulation energy generates a plurality of electrical fields having different orientations that stimulate the dorsal horn neuronal elements.

Abstract translation: 向具有医疗状况的患者提供治疗的方法包括根据刺激程序将电刺激能量递送到患者的脊髓，该刺激程序优先地刺激背脊背神经元元件在脊髓中的背角神经元元件。 递送的电刺激能量产生具有刺激背角神经元元件的具有不同取向的多个电场。