公开(公告)号：WO2007100696A2

公开(公告)日：2007-09-07

申请号：PCT/US2007/004794

申请日：2007-02-23

Applicant: DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

Inventor： DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

IPC: G01R33/36 ,  G01R33/34

CPC classification number: G01R33/34076 ,  G01R33/34046 ,  G01R33/3453 ,  G01R33/3614

Abstract: A Class-E amplifier has bee adapted for use in the radio frequency section of a magnetic resonance imaging (MRI) system. A drive signal is produces by modulating the envelope of a radio frequency carrier signal and then applied to a switch in the Class-E amplifier. The switch is connected in series with a choke between a supply voltage terminal and circuit ground with an output node formed between the choke and the switch. The output node is coupled to circuit ground by a shunt capacitor. In a preferred embodiment, a pair of such amplifiers, that are II radians out of phase, are connected to each rung of a transverse electromagnetic transmit array type radio frequency coil of the MRI system.

Abstract translation: E类放大器适用于磁共振成像（MRI）系统的射频部分。 通过调制射频载波信号的包络产生驱动信号，然后将其应用于E类放大器中的开关。 开关与电源电压端子和电路接地之间的扼流器串联连接，并在扼流圈和开关之间形成输出节点。 输出节点通过并联电容耦合到电路接地。 在一个优选实施例中，一对这样的放大器，即异相II弧形，连接到MRI系统的横向电磁发射阵列型射频线圈的每个梯级。

公开(公告)号：WO2007053507A1

公开(公告)日：2007-05-10

申请号：PCT/US2006/042195

申请日：2006-10-30

Applicant: KENERGY, INC. ,  DENKER, Stephen ,  BEUTLER, Arthur, J. ,  BULKES, Cherik

Inventor： DENKER, Stephen ,  BEUTLER, Arthur, J. ,  BULKES, Cherik

IPC: A61N1/16 ,  A61N1/37 ,  G01R33/422

CPC classification number: A61N1/375 ,  A61N1/086 ,  A61N1/3718

Abstract: An implantable electronic medical device is compatible with a magnetic resonance imaging (MRI) scanner. The device has a housing with exterior walls, each formed by a dielectric substrate with electrically conductive layers on interior and exterior surfaces. A series of slots divide each layer into segments. Segmenting the layers provides high impedance to eddy currents produced by fields of the MRI scanner, while capacitive coupling of the segments provides radio frequency shielding for components inside the housing. Electrical leads extending from the housing have a pair of coaxially arranged conductors and traps that attenuate currents induced in the conductors by the fields of the MRI scanner.

Abstract translation: 可植入电子医疗装置与磁共振成像（MRI）扫描器兼容。 该装置具有带有外壁的壳体，每个由内部和外部表面上具有导电层的电介质基底形成。 一系列插槽将每个层划分成多个段。 这些层的分段对于由MRI扫描仪的场产生的涡流提供高阻抗，而段的电容耦合为壳体内的部件提供射频屏蔽。 从壳体延伸的电引线具有一对同轴布置的导体和陷阱，其通过MRI扫描仪的场来衰减在导体中感应的电流。

公开(公告)号：WO2010111245A1

公开(公告)日：2010-09-30

申请号：PCT/US2010/028274

申请日：2010-03-23

Applicant: KENERGY, INC. ,  BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

IPC: A61N1/05 ,  H01R4/56 ,  A61N1/08 ,  A61N1/02

CPC classification number: A61N1/056 ,  A61N1/0563 ,  A61N1/086

Abstract: An electrical lead for implantation into an animal includes a cable to which a stimulation electrode is connected. The cable has a helical electrical conductor enclosed within an insulating sheath. The stimulation electrode has a tubular first contact band with a threaded lumen into which a portion of the helical electrical conductor is screwed. A second contact band has a threaded aperture and a helical electrode coil is screwed into both the threaded lumen and the threaded aperture. The two contact bands are separated so as to expose a portion of the electrode coil to enable electrical stimulation of tissue of the animal. Particular configurations of the helical electrode coil and the helical electrical conductor render the electrical lead compatible with MRI scanning.

Abstract translation: 用于植入动物的电引线包括连接有刺激电极的电缆。 电缆具有封闭在绝缘护套内的螺旋电导体。 刺激电极具有带螺纹内腔的管状第一接触带，螺旋导电体的一部分被拧入其中。 第二接触带具有螺纹孔，并且螺旋电极线圈拧入螺纹内腔和螺纹孔中。 两个接触带被分离以暴露电极线圈的一部分以使电刺激动物的组织。 螺旋电极线圈和螺旋电导体的特定配置使电引线与MRI扫描兼容。

公开(公告)号：WO2008137452A1

公开(公告)日：2008-11-13

申请号：PCT/US2008/062000

申请日：2008-04-30

Applicant: KENERGY ROYALTY COMPANY, LLC ,  BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

IPC: A61N1/18 ,  A61N1/00

CPC classification number: A61B5/04282 ,  A61N1/08 ,  A61N1/36114 ,  A61N1/36135 ,  A61N1/36167 ,  A61N1/36185 ,  A61N1/3622 ,  A61N1/36514 ,  A61N1/378

Abstract: An implantable device provides artificial electrical stimulation of animal tissue using a plurality of electrodes. A sensing unit detects a physiological parameter at a stimulation site. A control unit governs the stimulation, in response to the detected physiological parameter, by selecting certain pairs of the electrodes and by defining the shape, duration, and duty cycle of a segmented stimulation waveform. A stimulation signal generator produces the segmented stimulation waveform that has a first segment and a second segment that with respect to the first segment is longer in duration lesser in magnitude and opposite in polarity.

Abstract translation: 可植入装置使用多个电极提供动物组织的人造电刺激。 感测单元检测刺激部位的生理参数。 控制单元响应于检测到的生理参数，通过选择某些电极对并通过限定分段刺激波形的形状，持续时间和占空比来控制刺激。 刺激信号发生器产生分段刺激波形，其具有第一段和第二段，其相对于第一段在持续时间较长的范围内较小，极性相反。

公开(公告)号：WO2006115877A1

公开(公告)日：2006-11-02

申请号：PCT/US2006/014387

申请日：2006-04-18

Applicant: KENERGY, INC. ,  DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

Inventor： DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

IPC: A61N1/372 ,  A61N1/39 ,  A61N1/36

CPC classification number: A61N1/36114 ,  A61N1/37205 ,  A61N1/37211 ,  A61N1/3787 ,  A61N1/395

Abstract: An abnormally rapid ventricular cardiac rate that results from atrial fibrillation can be reduced by stimulating a vagal nerve of the heart. An apparatus for such stimulation includes a power transmitter that emits a radio frequency signal. A stimulator, implanted in a blood vessel adjacent the vagal nerve, has a pair of electrodes and an electrical circuit thereon. The electrical circuit receives the radio frequency signal and derives an electrical voltage from the energy of that signal. The electrical voltage is applied in the form of pulses to the pair of electrodes, thereby stimulating the vagal nerve. The pattern of that stimulating pulses can be varied in response to characteristics of the atrial fibrillation or the ventricular contractions.

Abstract translation: 通过刺激心脏的迷走神经可以减少心房颤动引起的异常快速的心室心率。 用于这种刺激的装置包括发射射频信号的功率发射器。 植入在迷走神经附近的血管中的刺激器在其上具有一对电极和电路。 电路接收射频信号，并根据该信号的能量导出电压。 以脉冲的形式将电压施加到该对电极，从而刺激迷走神经。 刺激脉冲的模式可以响应于心房颤动或心室收缩的特征而变化。

公开(公告)号：WO2008051913A1

公开(公告)日：2008-05-02

申请号：PCT/US2007/082106

申请日：2007-10-22

Applicant: BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

IPC: A61N1/05 ,  A61N1/16

CPC classification number: A61N1/05 ,  A61N1/086 ,  A61N1/3718

Abstract: An implantable biocompatible lead that is also compatible with a magnetic resonance imaging scanner for the purpose of diagnostic quality imaging is described. The implantable electrical lead comprises a plurality of coiled insulated conducting wires wound in a first direction forming a first structure of an outer layer of conductors of a first total length with a first number of turns per unit length and a plurality of coiled insulated conducting wires wound in a second direction forming a second structure of an inner layer of conductors of a second total length with a second number of turns per unit length. The first and the second structures are separated by a distance with a layer of dielectric material. The distance and dielectric material are chosen based on the field strength of the MRI scanner. The lead may further comprise a conducting layer formed by coating a material consisting of medium conducting particles in physical contact with each other and a mechanically flexible, biocompatible layer forming an external layer of lead and in contact with body tissue or body fluids.

Abstract translation: 描述了与用于诊断质量成像的目的的磁共振成像扫描仪兼容的可植入生物相容性引线。 可植入电引线包括沿第一方向缠绕的多个线圈绝缘导线，其形成第一总长度的第一总线的第一结构，第一总长度具有第一个单位长度的匝数，以及多个缠绕的线圈绝缘导线 在第二方向上形成具有第二总长度的导体内层的第二结构，其具有每单位长度的第二圈数。 第一和第二结构与介电材料层隔开距离。 基于MRI扫描仪的场强选择距离和介电材料。 引线还可以包括通过涂覆由相互物理接触的介质导电颗粒组成的材料形成的导电层，以及形成外部铅层并与身体组织或体液接触的机械柔性的生物相容性层。

公开(公告)号：WO2007146075A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/013437

申请日：2007-06-07

Applicant: BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

CPC classification number: A61B5/04012 ,  A61B5/0428 ,  H03F3/45475 ,  H03F2200/165 ,  H03F2200/171 ,  H03F2200/78 ,  H03F2203/45136

Abstract: An apparatus configured to detect transitions between relatively rising and falling amplitudes of an input signal Vin(t) arriving at a input node comprises a comparator having a first input, a second input, and an output for providing a two state output signal Vout(t) wherein state changes in the output signal Vout(t) correspond to the relatively rising amplitude of the input signal Vin(t) and the relatively falling amplitude of the input signal Vin(t). A delay circuit provides a shifted signal Vin(t+Δt) to the second input of the comparator, and a hysteresis circuit provides hysteretic deadband appended input signal Vin+ΔV to the first input of the comparator.

Abstract translation: 一种被配置为检测到达输入节点的输入信号Vin（t）的相对上升和下降幅度之间的转变的装置包括具有第一输入，第二输入和用于提供两状态输出信号Vout（t）的输出的比较器 ）其中输出信号Vout（t）中的状态变化对应于输入信号Vin（t）的相对上升的幅度和输入信号Vin（t）的相对下降的幅度。 延迟电路向比较器的第二输入提供移位信号Vin（t +Δt），并且迟滞电路向比较器的第一输入端提供迟滞的死区附加输入信号Vin +ΔV。

公开(公告)号：WO2007146060A2

公开(公告)日：2007-12-21

申请号：PCT/US2007/013413

申请日：2007-06-07

Applicant: BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

CPC classification number: A61N1/0573 ,  A61N1/05 ,  A61N1/056 ,  A61N1/37211 ,  A61N1/3787

Abstract: An apparatus provides an electrical interface with a lumen in a body of an animal. The apparatus has a self-anchoring lead structure for implantation inside the lumen and includes at least two insulated conductors each connected to a separate electrode. Each electrode has an associated shape memory material and a rounded terminus to grip the lumen wall for anchoring the lead when properly positioned. The conductor for each electrode also is connected to a control circuit that programmably selects electrodes for electrically interfacing with the lumen. The self-anchoring lead structure has a contracted state for insertion into the animal and an expanded stated in which the electrode termini engage a wall of the lumen.

Abstract translation: 一种装置提供与动物体内的内腔的电接口。 该装置具有用于植入内腔内的自锚定引线结构，并且包括至少两个绝缘导体，每个绝缘导体连接到单独的电极。 每个电极具有相关联的形状记忆材料和圆形的末端，以在适当定位时夹持管腔壁以锚定引线。 每个电极的导体也连接到可编程地选择用于与内腔电连接的电极的控制电路。 自锚定引线结构具有用于插入动物的收缩状态，并且扩展的状态表示电极末端接合管腔的壁。

公开(公告)号：WO2007001871A1

公开(公告)日：2007-01-04

申请号：PCT/US2006/023254

申请日：2006-06-15

Applicant: KENERGY, INC. ,  DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

Inventor： DENKER, Stephen ,  BULKES, Cherik ,  BEUTLER, Arthur, J.

IPC: A61N1/372 ,  A61N1/375

CPC classification number: A61N1/37229 ,  A61N1/375

Abstract: A medical device, such as a cardiac pacing device for an animal, includes an intravascular antenna that has a first coil for engaging a wall of a first blood vessel to receive a radio frequency signal. The first coil includes a first winding wound helically in a rotational direction along a longitudinal axis from a first end of the coil to a second end. A second winding that is connected to the a first winding at the second end, is wound helically in the same rotational direction along the longitudinal axis from the second end to the first end. An electronic circuit is implanted in the animal and is connected to the antenna to receive an electrical signal therefrom.

Abstract translation: 诸如用于动物的心脏起搏装置的医疗装置包括血管内天线，其具有用于接合第一血管的壁以接收射频信号的第一线圈。 第一线圈包括沿着从线圈的第一端到第二端的纵向轴线的旋转方向螺旋形地缠绕的第一线圈。 在第二端连接到第一绕组的第二绕组沿着从第二端到第一端的纵向轴线在相同的旋转方向上螺旋地卷绕。 将电子电路注入动物并连接到天线以从其接收电信号。

公开(公告)号：WO2010078552A1

公开(公告)日：2010-07-08

申请号：PCT/US2010/020039

申请日：2010-01-04

Applicant: KENERGY, INC. ,  BULKES, Cherik ,  DENKER, Stephen

Inventor： BULKES, Cherik ,  DENKER, Stephen

IPC: A61N1/372

CPC classification number: A61N1/05 ,  A61N1/086 ,  A61N1/3718

Abstract: An electrical lead (571), for implantation in an animal, is compatible with an MRI scanner. The electrical lead has a first plurality (573) of coiled insulated wires forming an outer layer of conductors that has a first inductance and a first capacitance, which act as a first parallel resonator tuned to a Larmor frequency of tissue in the animal. The lead may have a second plurality (575) of coiled insulated wires forming an inner layer of conductors within the outer layer of conductors. The second plurality of coiled insulated wires has a second inductance and a second capacitance that act as a second parallel resonator tuned to the Larmor frequency. Those parallel resonators mitigate signals at the Larmor frequency from traveling along the respective coil. An electrically conductive layer (572) extends around the inner and/or outer layer of conductors, and a layer (570) of a biologically compatible material forms the electrical lead's exterior surface.

Abstract translation: 用于植入动物的电引线（571）与MRI扫描仪兼容。 电引线具有形成具有第一电感和第一电容的导体外层的第一多个（573）线圈绝缘电线，该第一电感和第一电容充当调谐到动物组织的拉莫尔频率的第一并联谐振器。 引线可以具有在导体的外层内形成导体内层的第二多个（575）线圈绝缘电线。 第二组多个线圈绝缘导线具有第二电感和第二电容，其作为调谐到拉莫尔频率的第二并联谐振器。 那些并联谐振器以拉姆尔（Rarmor）频率减轻信号沿着相应的线圈行进。 导电层（572）围绕导体的内层和/或外层延伸，并且生物相容材料的层（570）形成电引线的外表面。