公开(公告)号：WO2017132334A1

公开(公告)日：2017-08-03

申请号：PCT/US2017/015066

申请日：2017-01-26

Applicant: MEDTRONIC, INC.

Inventor： DRAKE, Ronald A. ,  GARDESKI, Kenneth C. ,  PFEIFFER, Carla C. ,  SEIFERT, Kevin R. ,  STENER, Lester O. ,  BONNER, Matthew D.

IPC: A61N1/05 ,  A61N1/375

CPC classification number: A61N1/0573 ,  A61N1/3688 ,  A61N1/37205 ,  A61N1/3756 ,  A61N2001/0578 ,  A61N2001/058

Abstract: Methods and systems for positioning a leadlet pacing device (LPD) in cardiac tissue are disclosed. A delivery device is employed that comprises a proximal end, a distal end and a lumen therebetween sized to receive the LPD. The LPD has a leadlet extending therefrom that includes a means to fixate the leadlet to tissue. The delivery device comprises an introducer to introduce the LPD into the lumen of the delivery device. The LPD is loaded in the distal end of the lumen of the delivery device. The leadlet extends proximally from the LPD while the fixation means extends distally toward the LPD. A LPD mover is configured to advance the LPD out of the delivery device. A leadlet mover is configured to advance the leadlet out of the lumen delivery device and cause the leadlet to engage with cardiac tissue.

Abstract translation: 公开了用于将心电图起搏装置（LPD）定位在心脏组织中的方法和系统。 采用递送装置，其包括近端，远端和其间的尺寸被设定为容纳LPD的内腔。 LPD具有从其延伸的引线，该引线包括将引线固定到组织的装置。 输送装置包括导入器，以将LPD引入输送装置的内腔中。 LPD被装载在输送装置的内腔的远端中。 当固定装置朝向LPD向远侧延伸时，引线从LPD向近侧延伸。 LPD移动器被配置为将LPD推出输送装置。 导引头移动器被配置为将导引件推出管腔输送装置并使导引头与心脏组织接合。

公开(公告)号：WO2017031238A2

公开(公告)日：2017-02-23

申请号：PCT/US2016/047413

申请日：2016-08-17

Applicant: BOSTON SCIENTIFIC SCIMED INC.

Inventor： HERBST, Thomas J. ,  STOLEN, Craig

IPC: C12N5/077

CPC classification number: A61N1/326 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/205 ,  C12N5/0657

公开(公告)号：WO2016183417A1

公开(公告)日：2016-11-17

申请号：PCT/US2016/032308

申请日：2016-05-13

Applicant: MEDTRONIC, INC.

Inventor： GRUBAC, Vladimir ,  EGGEN, Michael D. ,  SEIFERT, Kevin R.

IPC: A61N1/05

CPC classification number: A61N1/0573 ,  A61N1/059

Abstract: Methods and systems of making a medical electrical lead type having a set of tines. A system for implantation of a lead medical electrical lead in contact with heart tissue, comprises an elongated lead body; a set of curved tines mounted to and extending from a distal end of the lead body, the tines having a length (dD) and an effective cross sectional area, and a delivery catheter. The delivery catheter encloses the lead body and has a distal capsule portion enclosing the tines. The tines exerting a spring force against the capsule and provide a stored potential energy. The tines when so fixated in the tissue provide a fixation energy. The deployment energy and the fixation energy of the tines are equivalent.

Abstract translation: 制造具有一组齿的医用电引线型的方法和系统。 用于植入与心脏组织接触的铅医用电导线的系统包括细长的引线体; 安装到引线本体的远端并且从引线主体的远端延伸的一组弯尖，具有长度（dD）和有效横截面面积的叉和输送导管。 输送导管封闭引线体并且具有封闭齿的远端胶囊部分。 尖齿对胶囊施加弹簧力并提供储存的势能。 当固定在组织中时，尖齿提供固定能量。 齿的部署能量和固定能相当。

公开(公告)号：WO2016126465A1

公开(公告)日：2016-08-11

申请号：PCT/US2016/014954

申请日：2016-01-26

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： KOOP, Brendan E.

IPC: A61N1/372 ,  A61N1/362 ,  A61N1/375 ,  A61N1/05

CPC classification number: A61N1/36514 ,  A61N1/0573 ,  A61N1/362 ,  A61N1/368 ,  A61N1/37205 ,  A61N1/37288 ,  A61N1/3756 ,  A61N2001/0585

Abstract: An implantable medical device (IMD) may include a housing having a proximal end and a distal end and a set of one or more electrodes connected to but spaced apart from the housing. The IMD may further include a controller disposed within the housing, wherein the controller is configured to sense cardiac electrical signals, and deliver electrical stimulation pulses via the first set of one or more electrodes. In some embodiments, a first portion of the housing is configured to be disposed at least partly within a coronary sinus of a patient's heart and a second portion of the housing is configured to be disposed at least partly within a right atrium of the patient's heart.

Abstract translation: 可植入医疗装置（IMD）可以包括具有近端和远端的壳体，以及连接到壳体但间隔开的一个或多个电极的一组。 IMD还可以包括设置在壳体内的控制器，其中控制器被配置为感测心脏电信号，并经由第一组一个或多个电极传送电刺激脉冲。 在一些实施例中，壳体的第一部分被配置为至少部分地设置在患者心脏的冠状窦内，并且壳体的第二部分被配置为至少部分地设置在患者心脏的右心房内。

公开(公告)号：WO2015168153A1

公开(公告)日：2015-11-05

申请号：PCT/US2015/028048

申请日：2015-04-28

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： SCHMIDT, Brian L. ,  HAASL, Benjamin J. ,  EDGELL, John M. ,  SACHS, Dana

IPC: A61N1/05 ,  A61N1/372 ,  A61N1/375

CPC classification number: A61N1/059 ,  A61B6/12 ,  A61B90/39 ,  A61B2090/3966 ,  A61N1/0573 ,  A61N1/37205 ,  A61N1/3756

Abstract: An implantable leadless cardiac pacing device including a housing having a proximal end and a distal end, an electrode positioned proximate the distal end of the housing configured to be positioned adjacent cardiac tissue, and a tissue anchoring member extending from the distal end of the housing configured to secure the housing to cardiac tissue. The device further includes a tissue engagement verification feature configured to provide feedback upon engagement of the tissue anchoring member in cardiac tissue.

Abstract translation: 一种可植入式无引线心脏起搏装置，包括具有近端和远端的壳体，邻近所述壳体的远端定位的电极，被配置成邻近心脏组织定位，以及组织锚固构件，其从所述壳体的远端延伸配置 以将壳体固定到心脏组织。 该装置还包括组织接合验证特征，其被配置为在组织锚固构件接合在心脏组织中时提供反馈。

公开(公告)号：WO2015134209A1

公开(公告)日：2015-09-11

申请号：PCT/US2015/016899

申请日：2015-02-20

Applicant: THE SPECTRANETICS CORPORATION

Inventor： CARVER, Robert ,  LEE, Weston, H. ,  KAGARISE, Brian, E. ,  HOO, Bruce, A. ,  GRACE, Kenneth P. ,  GLEASON, Peter Wilbur ,  HALBERT, Phillip Charles

IPC: A61N1/365

CPC classification number: A61N1/0573 ,  A61B17/32002 ,  A61N2001/0578

Abstract: Methods and devices for separating an implanted object, such as a pacemaker lead, from tissue surrounding such object in a patient's vasculature system. Specifically, the surgical device includes a handle, an elongate sheath and a circular cutting blade that extends from the distal end of the sheath upon actuating the handle. The circular cutting blade is configured to engage the tissue surrounding an implanted lead and cut such tissue in a coring fashion as the surgical device translates along the length of the lead, thereby allowing the lead, as well as any tissue remaining attached to the lead, to enter the device's elongate shaft. The surgical device has a barrel cam cylinder in the handle assembly that imparts rotation of the blade and a separate cam mechanism in the tip of outer sheath assembly that imparts and controls the extension and retraction of the blade. The barrel cam cylinder and cam mechanism cooperate to cause the blade to rotate in a first direction and extend from and retract in the outer sheath due to a first actuation of the handle and to rotate in a second direction and extend and retract in the outer sheath due to a second actuation of the handle.

Abstract translation: 用于将植入物体（例如起搏器引线）从患者血管系统中围绕该物体的组织分离的方法和装置。 具体地说，手术装置包括手柄，细长护套和圆形切割刀片，它们在致动手柄时从护套的远端延伸。 圆形切割刀片被配置为接合植入的引线周围的组织并且以取芯方式切割这样的组织，因为外科手术装置沿着引线的长度平移，从而允许引线以及保留附着到引线的任何组织， 进入设备的细长轴。 手术装置在手柄组件中具有桶形凸轮圆柱体，其将叶片的旋转和在外护套组件的尖端中的单独的凸轮机构赋予并控制叶片的伸缩。 筒状凸轮缸和凸轮机构协作，使得刀片在第一方向上旋转并且由于手柄的第一致动而在外护套中延伸并从外套中缩回并且在第二方向上旋转并且在外护套中延伸和缩回 由于手柄的第二次致动。

公开(公告)号：WO2015017273A1

公开(公告)日：2015-02-05

申请号：PCT/US2014/048213

申请日：2014-07-25

Applicant: MEDTRONIC, INC.

Inventor： RYS, Kenneth, D. ,  ANDERSON, Thomas, A. ,  GRUBAC, Vladimir ,  KUHN, Jonathan, I.

IPC: A61N1/05 ,  A61N1/372

CPC classification number: A61N1/0573 ,  A61N1/362 ,  A61N1/37205 ,  A61N1/37518 ,  A61N1/3756 ,  A61N2001/0585

Abstract: A tine portion for an implantable medical device includes a hook segment and a distal segment terminated by a tissue-piercing tip, wherein the distal segment extends from the hook segment to the tip. The hook segment, which is elastically deformable from a pre-set curvature, has one of: a round cross-section and an elliptical cross-section, while the distal segment has a flattened, or approximately rectangular cross-section. One or a pair of the tine portions may be integrally formed, with a base portion, from a superelastic wire, wherein the base portion is configured to fixedly attach to the device, for example, being captured between insulative members of a fixation subassembly.

Abstract translation: 用于可植入医疗装置的齿部分包括钩部分和由组织刺穿尖端终止的远端部分，其中远端部分从钩部分延伸到尖端。 可从预设曲率弹性变形的钩部分具有圆形横截面和椭圆形横截面中的一种，而远端部分具有扁平的或近似矩形的横截面。 一个或一对齿部可以与超弹性金属丝一起与底座部一体地形成，其中底座部被构造成固定地附接到装置，例如被捕获在固定子组件的绝缘构件之间。 / p>

公开(公告)号：WO2014182496A1

公开(公告)日：2014-11-13

申请号：PCT/US2014/035774

申请日：2014-04-29

Applicant: MEDTRONIC, INC.

Inventor： THOMPSON-NAUMAN, Amy E. ,  CHRISTIE, Melissa G.T.

IPC: A61N1/05 ,  A61N1/39

CPC classification number: A61N1/05 ,  A61N1/057 ,  A61N1/0573 ,  A61N1/3956 ,  A61N2001/0578 ,  A61N2001/058

Abstract: Anchoring mechanisms for an implantable electrical medical lead that is positioned within a substernal space are disclosed. The anchoring mechanisms fixedly-position a distal portion of the lead, that is implanted in the substernal space

Abstract translation: 公开了一种位于下层空间内的可植入电气医疗引线的固定机构。 锚固机构固定地定位引线的远端部分，其被植入在下层空间中

公开(公告)号：WO2014108903A1

公开(公告)日：2014-07-17

申请号：PCT/IL2014/050027

申请日：2014-01-09

Applicant: 4TECH INC. ,  TOBIS, Idan

Inventor： TOBIS, Idan ,  GILMORE, Michael ,  MURPHY, Charlotte

IPC: A61B17/06 ,  A61N1/05 ,  A61B19/00

CPC classification number: A61F2/2487 ,  A61B17/0401 ,  A61B2017/0443 ,  A61B2017/0464 ,  A61B2017/0649 ,  A61B2090/062 ,  A61F2/2478 ,  A61F2220/0016 ,  A61F2230/0091 ,  A61N1/0573

Abstract: A tissue anchor (20) comprises a helical tissue-coupling element (30) disposed about a longitudinal axis (32) thereof and having a distal tissue-penetrating tip (34). The helical tissue-coupling element (30) has: a first axial stiffness along a first axial portion (60) of the helical tissue-coupling element (30); a second axial stiffness along a second axial portion (62) of the helical tissue-coupling element (30) more distal than the first axial portion (60), which second axial stiffness is greater than the first axial stiffness; and a third axial stiffness along a third axial portion (64) more distal than the second axial portion (62), which third axial stiffness is less than the second axial stiffness. Other embodiments are also described.

Abstract translation: 组织锚固件（20）包括围绕其纵向轴线（32）设置并具有远侧组织穿透尖端（34）的螺旋组织连接元件（30）。 所述螺旋组织联接元件（30）具有：沿所述螺旋组织联接元件（30）的第一轴向部分（60）的第一轴向刚度; 沿所述螺旋组织联接元件（30）的第二轴向部分（62）的第二轴向刚度比所述第一轴向部分（60）更远，所述第二轴向刚度大于所述第一轴向刚度; 以及沿着比所述第二轴向部分（62）更远的第三轴向部分（64）的第三轴向刚度，所述第三轴向刚度小于所述第二轴向刚度。 还描述了其它实施例。

公开(公告)号：WO2014089201A1

公开(公告)日：2014-06-12

申请号：PCT/US2013/073103

申请日：2013-12-04

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： PETERSEN, Eric M. ,  ROWE, Todd ,  HE, Rui

IPC: A61N1/375 ,  A61N1/05

CPC classification number: A61N1/059 ,  A61N1/056 ,  A61N1/0573 ,  A61N1/3752

Abstract: Various embodiments concern a lead having a proximal section and a curbed section. The lead can comprise an outer tubular portion having a bias such that the lead assumes a curved shape along the curved section. The lead can further include an inner tubular portion extending within the outer tubular portion, the inner tubular portion comprising an inner coil conductor and an inner polymer jacket over the inner coil conductor along the curved section, the inner tubular member stiffer along the proximal section than the curved section, the outer tubular portion stiffer along the curved section relative to the inner tubular portion along the curved section such that the inner tubular portion can rotate relative to the outer tubular portion while the curved shape is substantially maintained. Relative rotation can extend and rotate and active fixation element.

Abstract translation: 各种实施例涉及具有近端部分和弯曲部分的引线。 引线可以包括具有偏置的外部管状部分，使得引线沿着弯曲部分呈弯曲形状。 引线还可以包括在外部管状部分内延伸的内部管状部分，内部管状部分包括内部线圈导体和沿着弯曲部分的内部线圈导体上的内部聚合物护套，内部管状部件沿着近端部分更硬， 弯曲部分，外部管状部分沿着弯曲部分相对于内部管状部分沿着弯曲部分更硬，使得内部管状部分可相对于外部管状部分旋转，同时基本保持弯曲形状。 相对旋转可以延伸和旋转和主动固定元件。